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Cited by 5Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysTakotsubo Cardiomyopathy and Associated Phenomena

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CLINICAL, MOLECULAR, AND EXOSOMAL MECHANISMS OF CARDIAC AND BRAIN DYSFUNCTION IN SEPSIS

Morris, Daniel C., Zhang, Zheng Gang, Jaehne, Anja K., Zhang, Jing, Rivers, Emanuel P.·2023·Shock
DOI 10.1097/shk.0000000000002015
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Abstract

Sepsis is a complex disease resulting from a dysregulated inflammatory response to an infection. Initiation of sepsis occurs from a localized infection that disseminates to the bloodstream placing all organ systems at risk. Septic shock is classically observed to manifest itself as systemic hypotension with hyporesponsiveness to vasopressor agents. Myocardial dysfunction occurs resulting in an inability to perfuse major organ systems throughout the body. Most importantly, the brain is hypoperfused creating an ischemic and inflammatory state resulting in the clinical observation of acute mental status changes and cognitive dysfunction commonly known as sepsis-associated encephalopathy. This short review describes the inflammatory molecular mechanisms of myocardial dysfunction, discusses the evidence of the dual roles of the microglia resulting in blood-brain barrier disruption, and suggests that septic-derived exosomes, endosome-derived lipid bilayer spheroids released from living cells, influence cardiac and neurological cellular function.

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  • Bacterial translocation due to increased intestinal permeability can lead to neuroinflammation, contributing to sepsis-associated encephalopathy.

    “Bacterial translocation due to increased intestinal permeability can lead to neuroinflammation, contributing to sepsis-associated encephalopathy, driven by inflammatory signals [36].”

    From Gastrointestinal function and nutritional interventions in septic shock (2025) · cites this paper as [36]

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Cited by

Sorted by citations

Metadata

Authors
Morris, D. C., Zhang, Z. G., Jaehne, A. K., Zhang, J., & Rivers, E. P.
Affiliations
Henry Ford Health (US)
Corresponding author
Morris, Daniel C.
ORCID
Venue
Shock
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2022-10-17
Volume
59
Issue
2
Pages
173-179
ISSN
1073-2322 (ISSN-L)
DOI
10.1097/shk.0000000000002015
OpenAlex
W4318966109
Cited by
5
References
5
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Locations
  • Shock (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
Keywords
sepsis, septic shock, cardiac dysfunction, sepsis-associated encephalopathy, microglia, blood-brain barrier disruption, exosomes, neuroinflammation, endosomes, cognitive impairment, hypotension, vasopressor resistance
MeSH terms
Brain Diseases, Heart, Humans, Cardiomyopathies, Shock, Septic, Sepsis

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