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Cited by 45Organ Transplantation Techniques and OutcomesRenal Transplantation Outcomes and TreatmentsBiochemical Acid Research Studies

α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation

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Ambrosi, Nella, Arrosagaray, Victoria, Guerrieri, Diego, Uva, Pablo D., Petroni, Jorgelina, Herrera, Mónica Buonpensiere, Iovanna, Juan L., León, Luis +3 more·2016·Transplantation
DOI 10.1097/tp.0000000000000981
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Abstract

BACKGROUND: Multiple factors have been implicated in the process of ischemia-reperfusion injury (IRI) in organ transplantation. Among these factors, oxidative damage seems to initiate the injury. α-lipoic acid (ALA) is a potent antioxidant that is used in patients with diabetic polyneuropathy. The aim of the present study was to determine the effect of ALA in patients undergoing simultaneous kidney-pancreas transplant by evaluating the functional recovery of the graft and biochemical markers of IRI. METHODS: Twenty-six patients were included in the following groups: (i) untreated control; (ii) donor and recipient (DR) ALA-treated, in which ALA was administered both to the deceased donor and to the recipients; and (iii) recipient ALA-treated group. The expression of inflammatory genes, as observed in biopsies taken at the end of surgery, as well as the serum cytokines, secretory leukocyte protease inhibitor, regenerating islet-derived protein 3β/pancreatitis-associated protein, amylase, lipase, glucose, and creatinine levels were quantified as markers of organ function. RESULTS: The DR group showed high levels of TGFβ and low levels of C3 and TNFα in the kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies. Decreases in serum IL-8, IL-6, secretory leukocyte protease inhibitor, and regenerating islet-derived protein 3 β/pancreatitis-associated protein were observed after surgery in the DR group. Serum lipase and amylase were lower in the DR group than in the control and recipient groups. Early kidney dysfunction and clinical pancreatitis were higher in the control group than in either treatment group. CONCLUSIONS: These results show that ALA preconditioning is capable of reducing inflammatory markers while decreasing early kidney dysfunction and clinical posttransplant pancreatitis.

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  • α-Lipoic acid has a protective anti-inflammatory effect in patients undergoing simultaneous kidney and pancreatic transplantation, with markedly reduced serum IL-8 and IL-6.

    “α-lipoic acid has been shown to have a protective anti-inflammatory effect in patients undergoing simultaneous kidney and pancreatic transplantation (Ambrosi et al. 2016). The preventive evaluation revealed that the serum inflammatory markers such as IL-8 and IL-6 were markedly reduced.”

    From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ambrosi et al. 2016

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Authors
Ambrosi, N., Arrosagaray, V., Guerrieri, D., Uva, P. D., Petroni, J., Herrera, M. B., Iovanna, J. L., León, L., Incardona, C., Eduardo Chuluyan, H., & Casadei, D. H.
Affiliations
  • Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
  • Aix-Marseille Université (FR)
ORCID
Venue
Transplantation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-04
Volume
100
Issue
4
Pages
908-915
ISSN
0041-1337 (ISSN-L)
DOI
10.1097/tp.0000000000000981
OpenAlex
W2331649020
Cited by
45
References
40
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 2 · 2016: 2
FWCI
3.36
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • Conicet (submittedVersion, cc-by-nc-sa)
Funders
  • Consejo Nacional de Investigaciones Científicas y Técnicas
  • Secretaría de Ciencia y Técnica, Universidad de Buenos Aires (2014–2017)
Topics
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords
alpha-lipoic acid, ischemia-reperfusion injury, simultaneous pancreas-kidney transplantation, oxidative stress, renal dysfunction, inflammatory cytokines, TGF-beta, heme oxygenase, secretory leukocyte protease inhibitor
MeSH terms
Pancreatitis-Associated Proteins, Adult, Anti-Inflammatory Agents, Antioxidants, Argentina, Female, Humans, Kidney Diseases, Thioctic Acid, Male, Middle Aged, Pancreatic Diseases, Prospective Studies, Time Factors, Biomarkers, Reperfusion Injury, Kidney Transplantation, Pancreas Transplantation, Treatment Outcome, Oxidative Stress, Inflammation Mediators, Young Adult

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