The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Serum copper and zinc levels in individuals with autism spectrum disorders
Abstract
Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim of this study was to investigate the serum levels of zinc (Zn) and copper (Cu) in Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed with ASD and 60 healthy sex-matched and age-matched control participants were assessed for serum Zn and Cu content at admission. The severity of ASD was also evaluated using the Childhood Autism Rating Scale (CARS) score. The results indicated that the mean serum Zn levels and Zn/Cu ratio were significantly lower in children with ASD compared with normal cases (P<0.001, respectively), whereas serum Cu levels were significantly higher (P<0.001). There was a significant negative association between Zn/Cu and CARS scores (r=-0.345, P=0.007). On the basis of the receiver operating characteristic curve, the optimal cut-off value of serum levels of Zn/Cu as an indicator for an auxiliary diagnosis of autism was projected to be 0.665, which yielded a sensitivity of 90.0% and a specificity of 91.7%; the area under the curve was 0.968 (95% confidence interval, 0.943-0.993). In conclusion, these results suggested an association between serum levels of Zn and Cu and ASD among Chinese patients, and the Zn/Cu ratio could be considered a biomarker of ASD.
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In the citing paper
“Disruptions in fetal copper homeostasis during brain development might contribute to ASD risk, with both elevated and decreased copper levels linked with autism [172–174].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [174]
In the citing paper
“Disruptions in fetal copper homeostasis during brain development might contribute to ASD risk, with both elevated and decreased copper levels linked with autism [172–174].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [172]
Citations
Cites
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Zinc and immune function: the biological basis of altered resistance to infection
Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606
ZINC AND THE RISK FOR INFECTIOUS DISEASE
Walker, C. L. F., & Black, R. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073054 · Cited by 498
Basso, M., Pozzi, S., Tortarolo, M., Fiordaliso, F., Bisighini, C., Pasetto, L., Spaltro, G., Lidonnici, D., Gensano, F., Battaglia, E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425066 · Cited by 295
Copper Delivery by Metallochaperone Proteins
Rosenzweig, A. C. (2001) · Accounts of Chemical Research · doi:10.1021/ar000012p · Cited by 279
Genetics of autistic disorders: review and clinical implications
Freitag, C. M., Staal, W., Klauck, S. M., Duketis, E., & Waltes, R. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0076-x · Cited by 225
Zinc in the central nervous system: From molecules to behavior
Gower‐Winter, S. D., & Levenson, C. W. (2012) · BioFactors · doi:10.1002/biof.1012 · Cited by 208
The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders
Faber, S., Zinn, G. M., Kern, J. C., & Kingston, H. M. (2009) · Biomarkers · doi:10.1080/13547500902783747 · Cited by 200
The role of zinc and copper in autism spectrum disorders
Bjørklund, G. (2013) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2013-1932 · Cited by 181
Self-citationSajdel, E. M., Xu, M. Q., McGinnis, W. R., & Koibuchi, N. (2010) · The Cerebellum · doi:10.1007/s12311-010-0223-4 · Cited by 147
Cited by
Sorted by citations
The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509
Cross talk: the microbiota and neurodevelopmental disorders
Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271
Meguid, N. A., Anwar, M., Bjørklund, G., Hashish, A., Chirumbolo, S., Hemimi, M., & Sultan, E. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9948-1 · Cited by 79
Self-citation
Metadata
- Authors
- Li, S.-O., Wang, J.-L., Bjørklund, G., Zhao, W.-N., & Yin, C.-H.
- Affiliations
- Council for Nutritional and Environmental Medicine (NO)
- ORCID
- Bjørklund, Geir
- Venue
- NeuroReport
- Published
- 2014-10-22
- Volume
- 25
- Issue
- 15
- Pages
- 1216-1220
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2134837100
- Cited by
- 121
- References
- 26
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 8 · 2014: 1
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- autism spectrum disorder, serum zinc, serum copper, copper/zinc ratio, trace elements, biomarkers, autism severity, auxiliary diagnosis, Chinese children
- MeSH terms
- Blood Chemical Analysis, Child Development Disorders, Pervasive, Child, Preschool, China, Copper, Fasting, Female, Humans, Male, Patient Admission, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity, Zinc, Biomarkers
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- Li, S.-O., Wang, J.-L., Bjørklund, G., Zhao, W.-N., & Yin, C.-H. (2014). Serum copper and zinc levels in individuals with autism spectrum disorders. NeuroReport. https://doi.org/10.1097/wnr.0000000000000251
