The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Pivotal response treatment prompts a functional rewiring of the brain among individuals with autism spectrum disorder
Open accessAbstract
Behavioral interventions for autism have gained prominence in recent years; however, the neural-systems-level targets of these interventions remain poorly understood. We use a novel Bayesian framework to extract network-based differences before and after a 16-week pivotal response treatment (PRT) regimen. Our results suggest that the functional changes induced by PRT localize to the posterior cingulate and are marked by a shift in connectivity from the orbitofrontal cortex to the occipital-temporal cortex. Our results illuminate a potential PRT-induced learning mechanism, whereby the neural circuits involved during social perception shift from sensory and attentional systems to higher-level object and face processing areas.
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“More recent work has demonstrated the presence of developmental trajectories as revealed through increasingly sophisticated spatio-spectral analyses, and has revealed how differences in the trajectories of EEG power in high-risk infants may represent an endophenotypes of ASD 91,92”
From Autism spectrum disorder (2020) · cites this paper as [92]
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Advances in functional and structural MR image analysis and implementation as FSL
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The Brain's Default Network: Anatomy, Function, and Relevance to Disease
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Self-citationSequence-independent segmentation of magnetic resonance images
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Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0138-4 · Cited by 1,859
A Pivotal Response Treatment Package for Children With Autism Spectrum Disorder: An RCT
Gengoux, G. W., Abrams, D. A., Schuck, R., Millan, M. E., Libove, R., Ardel, C. M., Phillips, J. M., Fox, M., Frazier, T. W., & Hardan, A. Y. (2019) · Pediatrics · doi:10.1542/peds.2019-0178 · Cited by 121
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Circuits for social learning: a unified model and application to autism spectrum disorder
DeMayo, M. M., Young, L. J., Hickie, I. B., Song, Y. J. C., & Guastella, A. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.034 · Cited by 52
Metadata
- Authors
- Venkataraman, A., Yang, D. Y.-J., Dvornek, N., Staib, L. H., Duncan, J. S., Pelphrey, K. A., & Ventola, P.
- Affiliations
- Children's National (US)
- Corresponding author
- Venkataraman, Archana
- ORCID
- Venue
- NeuroReport
- Published
- 2016-09-28
- Volume
- 27
- Issue
- 14
- Pages
- 1081-1085
- ISSN
- 0959-4965 (ISSN-L)
- PMC
- PMC5007196
- OpenAlex
- W2516965440
- Cited by
- 24
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 4
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1s10rr019895-01, UL1TR001863)
- National Institute of Mental Health (R01MH100028, T32MH018268)
- National Institute of Neurological Disorders and Stroke (R01NS035193)
- National Center for Research Resources (S10_RR019895, S10RR029676)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD090257)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Pivotal Response Treatment, autism spectrum disorder, posterior cingulate cortex, orbitofrontal cortex, social perception, face processing, Bayesian network analysis
- MeSH terms
- Autism Spectrum Disorder, Bayes Theorem, Behavior Therapy, Brain, Child, Child, Preschool, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen
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