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Is there a link between sleep changes and memory in Alzheimer's disease?
Open accessAbstract
Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD patients. Postlearning sleep was recorded. Sleep spindles were globally reduced in aging and AD. AD patients also exhibited a further decrease in fast spindles. Besides, mean intensity of fast spindles was positively correlated, in AD patients, with immediate recall performance. Our results are the first report of a specific decrease in fast spindles in AD, associated with learning abilities. They also give further hints for a functional differentiation between slow and fast spindles.
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“SD may exacerbate cognitive deficits in AD through impairment of sleep-dependent memory consolidation [565, 566].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [566]
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Metadata
- Authors
- Rauchs, G., Schabus, M., Parapatics, S., Bertran, F., Clochon, P., Hot, P., Denise, P., Desgranges, B., Eustache, F., Gruber, G., & Anderer, P.
- Affiliations
- Inserm (FR)
- University of Liège (BE)
- Siesta Group (Austria) (AT)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Medical University of Vienna (AT)
- Corresponding author
- Rauchs, Géraldine
- Schabus, Manuel
- ORCID
- Venue
- NeuroReport
- Published
- 2008-07-16
- Volume
- 19
- Issue
- 11
- Pages
- 1159-1162
- ISSN
- 0959-4965 (ISSN-L)
- PMC
- PMC2925139
- OpenAlex
- W2013563458
- Cited by
- 179
- References
- 28
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 20 · 2021: 16 · 2020: 18 · 2019: 15 · 2018: 9 · 2017: 4 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 5
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- Alzheimer's disease, sleep spindles, fast spindles, memory consolidation, episodic memory, aging, memory impairment, immediate recall
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Cognition, Female, Humans, Learning, Male, Memory, Mental Recall, Sleep, Sleep Stages, Sleep, REM, Polysomnography
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