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Is there a link between sleep changes and memory in Alzheimer's disease?
Open accessAbstract
Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD patients. Postlearning sleep was recorded. Sleep spindles were globally reduced in aging and AD. AD patients also exhibited a further decrease in fast spindles. Besides, mean intensity of fast spindles was positively correlated, in AD patients, with immediate recall performance. Our results are the first report of a specific decrease in fast spindles in AD, associated with learning abilities. They also give further hints for a functional differentiation between slow and fast spindles.
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“SD may exacerbate cognitive deficits in AD through impairment of sleep-dependent memory consolidation [565, 566].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [566]
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Liguori, C., Romigi, A., Nuccetelli, M., Zannino, S., Sancesario, G., Martorana, A., Albanese, M., Mercuri, N. B., Izzi, F., Bernardini, S., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2510 · Cited by 365
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“Normal aging provides a natural experiment in which spindles show significant reduction in number and density compared with younger adults (Nicolas et al., 2001; Crowley et al., 2002; Rauchs et al., 2008).”
ResultMemory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine
Kjaerby, C., Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01102-9 · Cited by 306
Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment
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“Our finding that fast but not slow spindles showed reductions is also in keeping with evidence that fast spindles (typically 13–15 Hz) are most disrupted in AD (Rauchs et al., 2008).”
InfluentialLustenberger, C., Boyle, M. R., Alagapan, S., Mellin, J. M., Vaughn, B. V., & Frӧhlich, F. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.044 · Cited by 281
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The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease
Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179936 · Cited by 216
Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings
Zhang, Y., Ren, R., Yang, L., Zhang, H., Shi, Y., Okhravi, H. R., Vitiello, M. V., Sanford, L. D., & Tang, X. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01897-y · Cited by 238
“Sleep parameters which could not be meta-analyzed PSA data [41, 42, 48, 49, 52, 59], CAP parameters [46], and sleep spindles [25, 40, 45, 47, 49] were also explored for possible differences between AD patients and controls (Table S8).”
BackgroundCharacterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes
Sterniczuk, R., Dyck, R. H., LaFerla, F. M., & Antle, M. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.013 · Cited by 208
Branger, P., Arenaza-Urquijo, E. M., Tomadesso, C., Mézenge, F., André, C., de Flores, R., Mutlu, J., de La Sayette, V., Eustache, F., Chételat, G., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.009 · Cited by 186
“…disease, in patients with mild cognitive impairment (MCI), a clinical stage considered to be prodromal AD (Beaulieu-Bonneau and Hudon, 2009), and have been found to be related to memory impairment (Bonanni et al., 2005; Hot et al., 2011; Rauchs et al., 2008, 2013; Westerberg et al., 2010, 2012).”
BackgroundSelf-citationForm and function of sleep spindles across the lifespan
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“Alzheimer’s disease patients who presented with greater mean intensity and number of fast spindles performed better in an episodic memory (story recall task) than patients who showed lower spindle numbers and intensity [165].”
BackgroundSleep disturbance in mental health problems and neurodegenerative disease
Anderson, K. N., & Bradley (2013) · Nature and Science of Sleep · doi:10.2147/nss.s34842 · Cited by 198
“188 As the disease progresses, NREM sleep stages become progressively more difficult to stage, although REM sleep duration remains relatively stable and loss of REM atonia or significant REM sleep behavior disorder is uncommon.”
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“Rauchs et al. (2008) gave younger adults, healthy older adults, and Alzheimer’s disease (AD) patients a very strong encoding task (semantic encoding strategy, frequent tests) and a less-strong encoding task (single reading of a story).”
BackgroundResultCasagrande, M., Forte, G., Favieri, F., & Corbo, I. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19148457 · Cited by 211
Sleep spindles in Parkinson's disease may predict the development of dementia
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Macro and micro sleep architecture and cognitive performance in older adults
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“For example, patients with AD performed better on memory testing if a greater number of fast spindles were present 75 .”
for the Osteoporotic Fractures in Men (MrOS) Study Group, Song, Y., Blackwell, T., Yaffe, K. S., Ancoli‐Israel, S., Redline, S. S., & Stone, K. L. (2015) · SLEEP · doi:10.5665/sleep.4500 · Cited by 166
“64,65 68 More-over, the amount of hippocampal activity expressed during Stage N3 positively correlated with improved performance on episodic memory the next day in young adults.”
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“PSG studies reveal macro- and micro-structure sleep abnormalities in both clinical and preclinical AD (Prinz et al., 1982; Bliwise, 1993; Rauchs et al., 2008; Westerberg et al., 2012; Hita-Yañez et al., 2013; Liguori et al., 2014; Maestri et al., 2015).”
BackgroundfMRI and sleep correlates of the age‐related impairment in motor memory consolidation
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“The lack of a similar decrease in the amount of SWA suggests that the 1-Hz slow activity could be the potential sleep EEG marker, even though it does not differentiate AD from MCI patients (Reda et al., 2017).”
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“…et al., 2011), declarative memory consolidation in young subjects (van der Helm et al., 2011), verbal memory encoding before sleep in patients with Alzheimer’s disease (Rauchs et al., 2008) and predict better episodic encoding the next morning in young and older adults (Mander et al., 2013).”
BackgroundNREM Sleep Oscillations and Brain Plasticity in Aging
Fogel, S. M., Martin, N. G., Lafortune, M., Barakat, M., Debas, K., Laventure, S., Latreille, V., Gagnon, J., Doyon, J., & Carrier, J. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00176 · Cited by 134
“A study in Alzheimer patients found no association between spindles and overnight memory retention, but instead found a positive relationship between memory performance prior to sleep and spindle intensity in subsequent sleep (Rauchs et al., 2008).”
BackgroundSlow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease
Lee, Y. F., Gerashchenko, D., Timofeev, I., Bacskai, B. J., & Kastanenka, K. V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00705 · Cited by 127
“It will not cover other NREM sleep-associated rhythms, such as thalamo-cortical sleep spindles, or hippocampal ripples, nor will it discuss REM sleep disruptions in AD, that have been reviewed or described elsewhere (Christos, 1993; Rauchs et al., 2008; Pase et al., 2017).”
BackgroundClinical management of sleep disturbances in Alzheimer's disease: current and emerging strategies
Urrestarazu, E., & Iriarte, J. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s76706 · Cited by 117
“For example, Rauchs et al 19,20 found that the mean intensity of fast spindles was positively correlated, in AD patients, with immediate recall performance, while the amount of SWS was positively correlated with the ability to retrieve recent autobiographical memories.”
Sleep disturbances and mild cognitive impairment: A review
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“An study performed with polysomnography compared 14 healthy elderly subjects with 14 AD patients and conclude that a more pronounced fast spindles decrease became evident in AD patients compared to old controls [33].”
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“, 2017) and fast sleep spindles show a gradually decreasing density in MCI and AD (Rauchs et al., 2008; Gorgoni et al., 2016).”
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“Following this hypothesis, this could explain why other studies investigating SS densities in neurodegenerative diseases do not find significant changes (Happe et al., 2004; Rauchs et al., 2008).”
ResultLocal Sleep and Alzheimer’s Disease Pathophysiology
Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97
“In aging and MCI, these deficits are associated with DG/CA3 region hyperactivity (Yassa et al., 2011a,b), EC thinning (Reagh et al., 2018), and perforant path degeneration (Yassa et al., 2010a, 2011b).”
BackgroundStructural brain correlates of human sleep oscillations
Saletin, J. M., van der Helm, E., & Walker, M. P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.021 · Cited by 93
“…in hippocampal gray matter and episodic memory, including Alzheimer's disease, Schizophrenia as well as sleep apnea (Barnes et al., 2009; Ferrarelli et al., 2007; Hedden and Gabrieli, 2004; Himanen et al., 2003; Joo et al., 2010; Kloepfer et al., 2009; Rauchs et al., 2008; Tamminga et al., 2010).”
InfluentialSleep Influences the Severity of Memory Disruption in Amnestic Mild Cognitive Impairment
Westerberg, C. E., Lundgren, E. M., Florczak, S. M., Mesulam, M. M., Weıntraub, S., Zee, P. C., & Paller, K. A. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181e30846 · Cited by 97
Age-related changes in sleep in inbred mice are genotype dependent
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Sleep-Dependent Memory Consolidation in Healthy Aging and Mild Cognitive Impairment
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“The amount of SWS becomes greatly reduced and NREM stage 2 spindles and K-complexes diminish in frequency, intensity, and morphological integrity (Bliwise 1993; Petit et al. 2004; Rauchs et al. 2008).”
BackgroundInfluentialElectroencephalographic prodromal markers of dementia across conscious states in Parkinson’s disease
Latreille, V., Carrier, J., Gaudet-Fex, B., Brazète, J. R., Panisset, M., Chouinard, S., Postuma, R. B., & Gagnon, J. (2016) · Brain · doi:10.1093/brain/aww018 · Cited by 92
The Effects of Yoga on Patients with Mild Cognitive Impairment and Dementia: A Scoping Review
Brenes, G. A., Sohl, S. J., Wells, R. E., Befus, D., Campos, C. L., & Danhauer, S. C. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.10.013 · Cited by 94
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Self-citationQuantitative EEG of Rapid-Eye-Movement Sleep
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Effects of state and trait anxiety on sleep structure: A polysomnographic study in 1083 subjects
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The Sleep Side of Aging and Alzheimer’s Disease
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Sleep spindle alterations in patients with Parkinson's disease
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“In AD, Rauchs et al. (2008) found no change in spindle density but found that fast spindles (defined as having frequencies of 13–15Hz) were significantly reduced when compared to agematched controls.”
BackgroundResultArsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model
Niño, S. A., Morales-Martínez, A., Chi-Ahumada, É., Carrizales, L., Salgado‐Delgado, R., Pérez‐Severiano, F., Díaz-Cintra, S. Y., Jiménez-Capdeville, M. E., & Zarazúa, S. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00278 · Cited by 64
Amyotrophic lateral sclerosis—Evolutionary and other perspectives
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“They worsen with dementia severity and are related to patients' cognitive deficits, especially memory impairments [5].”
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Treatment of sleep disturbance in Alzheimer's dementia
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“…sleep architecture in AD including increased sleep latency, increased rapid eye movement (REM) latency, less sleep efficiency, increased stage 1 NREM, and decreased REM sleep (Dykierek et al., 1998; Bonanni et al., 2005; Moraes et al., 2006; Martin and Ancoli-Israel, 2008; Rauchs et al., 2008).”
BackgroundMiller, M. A., Wright, H., Ji, C., & Cappuccio, F. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100991 · Cited by 56
“Sleep disturbances, including specific reduction in fast sleep spindles, may be one of the earliest signs of neurodegenerative disorders, including early Alzheimer’s disease (AD) [4].”
BackgroundSleep spindle abnormalities related to Alzheimer's disease: a systematic mini-review
Weng, Y.-Y., Lei, X., & Yu, J. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.07.044 · Cited by 62
The prevalence of sleep loss and sleep disorders in young and old adults
Jha, V. M. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100057 · Cited by 67
“The study showed that a specific decrease in rapid spindles in AD patients is linked to their learning capacities [116].”
BackgroundDevelopmental changes in sleep spindle characteristics and sigma power across early childhood
McClain, I. J., Lustenberger, C., Achermann, P., Lassonde, J. M., Kurth, S., & LeBourgeois, M. K. (2016) · Neural Plasticity · doi:10.1155/2016/3670951 · Cited by 52
“Data from a growing number of studies indicate sleep spindle abnormalities in individuals with mental retardation [16], autism spectrum disorder [17], neurodegenerative disease [18], sleep disorders [19], and mental illness [20–22].”
BackgroundEpisodic memory consolidation during sleep in healthy aging
Muehlroth, B. E., Rasch, B., & Werkle‐Bergner, M. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101304 · Cited by 57
Changes in sleep theta rhythm are related to episodic memory impairment in early Alzheimer's disease
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“In our group, we also found that early D patients with the faster spindles had the better performance in he episodic memory task (Rauchs et al., 2008).”
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Vorobyov, V., Kaptsov, V., Gordon, R. Y., Makarova, E. G., Podolski, I. Y., & Sengpiel, F. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142469 · Cited by 47
“4C, 5C) is in line both with the memory/learning impairment shown in the A 25-35 model of AD in rats [25, 26] and with the reduction of EEG sleep spindles observed in AD patients suffering disrupted performance [50].”
Katsuki, F., Gerashchenko, D., & Brown, R. E. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.002 · Cited by 50
Perentos, N., Martins, A. Q., Watson, T. C., Bartsch, U., Mitchell, N. L., Palmer, D. N., Jones, M. W., & Morton, A. J. (2015) · Brain · doi:10.1093/brain/awv026 · Cited by 49
“Interestingly, spindles are disrupted in many neurological disorders (Wiegand et al. , 1991; Ferrarelli et al. , 2007; Rauchs et al. , 2008; Christensen et al. , 2014) including Batten disease (Veneselli et al. , 2000).”
BackgroundInfluentialCordone, S., Scarpelli, S., Alfonsi, V., Gennaro, L. D., & Gorgoni, M. (2021) · Pharmaceuticals · doi:10.3390/ph14040383 · Cited by 50
“A reduction of sleep spindle activity has also been observed in AD and MCI compared to healthy elderly [125,129,134,135], mainly in terms of decreased centro-parietal fast (13–16 Hz) spindle density [125,135].”
BackgroundPeters, K. R., Ray, L. B., Fogel, S. M., Smith, V., & Smith, C. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091047 · Cited by 45
“Age-related decreases in spindle density have been reported for both slow (11–13 Hz) and fast (13–15 Hz) spindles [8].”
BackgroundMemory Processing in Relation to Sleep
Peigneux, P., & Smith, C. T. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00029-3 · Cited by 45
Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities
Romanella, S. M., Roe, D. L., Paciorek, R., Cappon, D., Ruffini, G., Menardi, A., Rossi, A., Rossi, S., & Santarnecchi, E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101067 · Cited by 46
Age-related differences and sexual dimorphism in canine sleep spindles
Iotchev, I. B., Kis, A., Turcsán, B., de Lara, D. R. T. F., Reicher, V., & Enikö Kubinyi, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-46434-y · Cited by 39
Sani, T. P., Bond, R. L., Marshall, C. R., Hardy, C. J. D., Russell, L. L., Moore, K. M., Slattery, C. F., Paterson, R. W., Woollacott, I., Wendi, I. P., et al. (2019) · eNeurologicalSci · doi:10.1016/j.ensci.2019.100212 · Cited by 38
Kundermann, B., Thum, A., Rocamora, R., Haag, A., Krieg, J.-C., & Hemmeter, U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.07.008 · Cited by 38
“…showing either an increased percentage of stage 1 sleep accompanied by a reduced proportion of slow wave sleep in AD (Bliwise et al., 1989; Loewenstein et al., 1982) or no differences in these parameters (Montplaisir et al., 1995; Rauchs et al., 2008), we did not pose a hypothesis in this regard.”
BackgroundResultInfluentialRetrieval of Recent Autobiographical Memories is Associated with Slow-Wave Sleep in Early AD
Rauchs, G., Piolino, P., Bertran, F., Sayette, V. D. L., Viader, F., Eustache, F., & Desgranges, B. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00114 · Cited by 36
Self-citationLiguori, C., Mercuri, N. B., Nuccetelli, M., Izzi, F., Bernardini, S., & Placidi, F. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180769 · Cited by 38
Xiao, S., Liu, Y.-J., Wang, L., Sha, Z., Che, X., Yu, Z., & Lee, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.875138 · Cited by 41
“In the meanwhile, sleep disturbance further accelerates the pathological progress and symptoms of AD including impairment of cognitive function (Rauchs et al., 2008; Ooms et al., 2014).”
BackgroundSleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings
Castelnovo, A., D’Agostino, A., Casetta, C., Sarasso, S., & Ferrarelli, F. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0713-2 · Cited by 34
Giri, S., Ranjan, A., Kumar, A., Amar, M., & Mallick, B. N. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24838 · Cited by 36
Gerstenberg, M., Furrer, M., Tesler, N., Franscini, M., Walitza, S., & Huber, R. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.060 · Cited by 34
Guadagni, V., Byles, H., Tyndall, A. V., Parboosingh, J. S., Longman, R. S., Hogan, D. B., Hanly, P. J., Younes, M. K., & Poulin, M. J. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13037 · Cited by 33
Slow wave sleep and accelerated forgetting
Atherton, K. E., Nobre, A. C., Lázár, A. S., Wulff, K., Whittaker, R. G., Dhawan, V., Lázár, Z. I., Zeman, A. Z., & Butler, C. (2016) · Cortex · doi:10.1016/j.cortex.2016.08.013 · Cited by 37
“Relatively few studies have investigated this relationship in older adults (e.g., Rauchs et al., 2008; SeeckHirschner et al., 2012) and it may be that the role of spindles in memory consolidation diminishes with age.”
BackgroundStokes, P. A., Rath, P., Possidente*, T., He, M., Purcell, S., Manoach, D. S., Stickgold, R., & Prerau, M. J. (2022) · SLEEP · doi:10.1093/sleep/zsac223 · Cited by 32
Li, K., Luo, X., Zeng, Q., Jiaerken, Y., Wang, S., Xu, X., Xu, X., Xu, J., Wang, C., Zhou, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55452-9 · Cited by 31
Cross, N. E., Lagopoulos, J., Duffy, S. L., Cockayne, N. L., Hickie, I. B., Lewis, S. J. G., & Naismith, S. L. (2013) · Behavioral Neuroscience · doi:10.1037/a0034154 · Cited by 34
Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy
Bender, A. C., Jaleel, A., Pellerin, K. R., Moguilner, S., Sarkis, R. A., Cash, S. S., & Lam, A. D. (2023) · Neurology · doi:10.1212/wnl.0000000000207942 · Cited by 31
“7,8 These results are concordant with similar fi ndings in healthy individuals 30 and in other disease states, including schizophrenia 31,32 and Alzheimer disease, 33 implying a clinically relevant change for patients with TLE with memory concerns.”
ResultDoes abnormal non-rapid eye movement sleep impair declarative memory consolidation?
Lu, W., & Göder, R. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.08.001 · Cited by 33
Miller, M. A., Wright, H., Hough, J., & Cappuccio, F. P. (2014) · InTech eBooks · doi:10.5772/58735 · Cited by 31
“Sleep disorder, in fact, may be one of the earliest signs of neurodegenerative disorders, including early Alzheimer’s disease (AD) [6].”
BackgroundWunderlin, M., Zeller, C. J., Senti, S. R., Fehér, K. D., Suppiger, D., Wyss, P., Koenig, T. W., Teunissen, C. E., Nissen, C., Klöppel, S., et al. (2023) · Age and Ageing · doi:10.1093/ageing/afad228 · Cited by 34
“SWS decreases with healthy ageing [5, 6], but to a greater extent in individuals with mild cognitive impairment and dementia [7, 8].”
BackgroundHanert, A., Schönfeld, R., Weber, F. D., Nowak, A., Döhring, J., Philippen, S., Granert, O., Burgalossi, A., Jan Born, A., Berg, D., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106378 · Cited by 34
“Furthermore, a more pronounced reduction in sleep spindles is observed as pathology progresses in MCI and AD (Gorgoni et al., 2016; Rauchs et al., 2008).”
BackgroundChampetier, P., André, C., Weber, F. D., Rehel, S., Ourry, V., Lanièpce, A., Antoine Lutz, A., Bertran, F., Cabé, N., Pitel, A., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac282 · Cited by 26
Self-citationPáez, A., Gillman, S. O., Dogaheh, S. B., Carnes, A., Dakterzada, F., Barbé, F., Dang‐Vu, T. T., & Ripoll, G. P. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14424 · Cited by 33
“3,20,31,32,49 We found that increased SP density predicted large, clinically significant decreases in ADAS-Cog scoresatbaselineand12months( > 10points)andhigherMMSEscores from baseline through 36 months (three to five points) in persons with mild to moderate AD.”
InfluentialMemory-relevant nap sleep physiology in healthy and pathological aging
Ladenbauer, J., Ladenbauer, J., Külzow, N., & Flöel, A. (2021) · SLEEP · doi:10.1093/sleep/zsab002 · Cited by 28
Dementia detection from brain activity during sleep
Ye, E. M., Sun, H., Krishnamurthy, P. V., Adra, N., Ganglberger, W., THOMAS, R. J., Lam, A. D., & Westover, M. B. (2022) · SLEEP · doi:10.1093/sleep/zsac286 · Cited by 29
Sleep’s contribution to memory formation
Lutz, N. D., Harkotte, M., & Jan Born, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00054.2024 · Cited by 51
Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder
van der Heijden, A. C., Hofman, W. F., de Boer, M., Nijdam, M. J., van Marle, H. J. F., Jongedijk, R. A., Olff, M., & Talamini, L. M. (2022) · SLEEP · doi:10.1093/sleep/zsac139 · Cited by 24
Linking brain structure, cognition, and sleep: insights from clinical data
Wei, R., Ganglberger, W., Sun, H., Hadar, P., Gollub, R. L., Pieper, S., Billot, B., Au, R., Iglesias, J. E., Cash, S. S., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad294 · Cited by 30
“It is thus to be expected that disease states that impact brain networks should alter these sleep oscillations, and it may be possible to read out sleep-brain oscillations to detect disease at various stages of evolution [14–18].”
Orlando, I. F., O’Callaghan, C., Lam, A. K. F., McKinnon, A. C., Tan, J. B., Michaelian, J. C., Kong, S. D. X., D'Rozario, A. L., & Naismith, S. L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02335-1 · Cited by 25
APOEε4 and slow wave sleep in older adults
Tranah, G. J., Yaffe, K. S., Nievergelt, C. M., Parimi, N., Glymour, M. M., Ensrud, K. E., Cauley, J. A., Ancoli‐Israel, S., Mariani, S., Redline, S. S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191281 · Cited by 24
“As demonstrated in previous studies, increased stage N3 might predicts worse episodic memory consolidation in the elderly [88] and may be detrimental to morning recall [73,91–94].”
ResultTransforming growth factor‐beta inhibits the expression of clock genes
Gast, H., Gordic, S., Petrzilka, S., Lopez, M., Müller, A. F., Gietl, A. F., Höck, C., Birchler, T., & Fontana, A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06640.x · Cited by 25
Rodríguez‐Labrada, R., Galicia-Polo, L., Canales‐Ochoa, N., Voss, U., Tuin, I., Peña-Acosta, A., Estupiñán‐Rodríguez, A., Medrano‐Montero, J., Vázquez‐Mojena, Y., González-Zaldívar, Y., et al. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.04.005 · Cited by 24
Optimal spindle detection parameters for predicting cognitive performance
Adra, N., Sun, H., Ganglberger, W., Ye, E. M., Dummer, L., Tesh, R. A., Westmeijer, M., Cardoso, M. D. S., Kitchener, E. G., Ouyang, A., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac001 · Cited by 22
Metadata
- Authors
- Rauchs, G., Schabus, M., Parapatics, S., Bertran, F., Clochon, P., Hot, P., Denise, P., Desgranges, B., Eustache, F., Gruber, G., & Anderer, P.
- Affiliations
- Inserm (FR)
- University of Liège (BE)
- Siesta Group (Austria) (AT)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Medical University of Vienna (AT)
- Corresponding author
- Rauchs, Géraldine
- Schabus, Manuel
- ORCID
- Venue
- NeuroReport
- Published
- 2008-07-16
- Volume
- 19
- Issue
- 11
- Pages
- 1159-1162
- ISSN
- 0959-4965 (ISSN-L)
- PMC
- PMC2925139
- OpenAlex
- W2013563458
- Cited by
- 179
- References
- 28
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 20 · 2021: 16 · 2020: 18 · 2019: 15 · 2018: 9 · 2017: 4 · 2016: 15 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 5
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- Alzheimer's disease, sleep spindles, fast spindles, memory consolidation, episodic memory, aging, memory impairment, immediate recall
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Cognition, Female, Humans, Learning, Male, Memory, Mental Recall, Sleep, Sleep Stages, Sleep, REM, Polysomnography
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