Parkinson’s disease and intensive exercise therapy—A systematic review and meta-analysis of randomized controlled trials
Abstract
Objective To evaluate and compare the effect of 3 intensive exercise therapy modalities - Resistance Training (RT), Endurance Training (ET) and Other Intensive Training Modalities (OITM) - in Parkinson's Disease (PD). Design A systematic review and meta-analysis of randomized controlled trials.Methods A systematic literature search was conducted (Embase, Pubmed, Cinahl, SPORTDiscus, Cochrane, PEDro), which identified 15 studies that were categorized as RT, ET or OITM. The different exercise modalities were reviewed and a meta-analysis evaluating the effect of RT on muscle strength was made.Results In PD intensive exercise therapy (RT, ET and OITM) is feasible and safe. There is strong evidence that RT can improve muscle strength in PD, which is underlined by the meta-analysis (g'=0.54 [95%CI 0.22;0.86]). There is moderate evidence that ET can improve cardio-respiratory fitness in PD. RT, ET and OITM may have beneficial effects on balance, walking performance, Unified Parkinson's Disease Rating Scale-III (UPDRS-III) score and quality of life in PD, but findings are inconsistent. No studies find deterioration in any outcomes following exercise therapy.Conclusion RT, ET and OITM all represent feasible, safe and beneficial adjunct rehabilitation therapies in PD.
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Exercise therapy in the form of endurance training, resistance training, intensive mixed training, or high-intensity interval training resulted in a reduction of clinical symptoms in Parkinson's disease.
“In addition, exercise therapy in the form of endurance training, resistance training, intensive mixed training, or high-intensity interval training (HIIT) resulted in a reduction of clinical symptoms in PD [145,146,147,148,149,150,151,152].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [147]
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Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Zhang, Q., Yang, X., Song, H., & Jin, Y. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101111 · Cited by 60 · see citing works
- Authors
- Uhrbrand, A., Stenager, E., Pedersen, M. S., & Dalgas, U.
- Affiliations
- Aarhus University (DK)
- University of Southern Denmark (DK)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 353
- Issue
- 1-2
- Pages
- 9-19
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2006584236
- Cited by
- 190
- References
- 96
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 17 · 2023: 16 · 2022: 22 · 2021: 18 · 2020: 27 · 2019: 25 · 2018: 20 · 2017: 16 · 2016: 11 · 2015: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Parkinson's disease, resistance training, endurance training, muscle strength, cardiorespiratory fitness, balance, walking performance, UPDRS-III, quality of life
- MeSH terms
- Exercise Therapy, Humans, Parkinson Disease, Randomized Controlled Trials as Topic
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