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World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines

Open access
Fiocchi, Alessandro, Brozek, Jan, Schünemann, Holger, Bahna, Sami L, von Berg, Andrea, Beyer, Kirsten, Bozzola, Martin, Bradsher, Julia, Compalati, Enrico, Ebisawa, Motohiro, Guzman, Maria Antonieta, Li, Haiqi, Heine, Ralf G, Keith, Paul, Lack, Gideon, Landi, Massimo, Martelli, Alberto, Rancé, Fabienne, Sampson, Hugh, Stein, Airton, Terracciano, Luigi, Vieths, Stefan·2010·World Allergy Organization Journal

Abstract

OverviewT here are no surveys of population and geographical trends in food allergy in adults or children (though the situation is different in pediatric asthma and rhinitis) and this unmet need is particularly felt for CMA.The perception of milk allergy is far more frequent than confirmed CMA.Patient reports of CMA range between 1 and 17.5%, 1 and 13.5%, and 1 to 4% in preschoolers, at children 5 to 16 years of age and adults respectively.Cow's milk-specific IgE sensitization point prevalence progressively decreased from about 4% at 2 years to less than 1% at 10 years of age in the German Multi-Centre Allergy Study.The most reliable data in epidemiology are those from birth cohorts that are free from selection bias.There are 5 such challenge-confirmed studies.The CMA prevalence during infancy ranged from 1.9% in a Finnish study, 2.16% in the Isle of Wight, 2.22% in a study from Denmark, 2.24% in the Netherlands, and up to 4.9% in Norway.Patients with CMA develop gastrointestinal symptoms in 32 to 60% of cases, skin symptoms in 5 to 90%, and anaphylaxis in 0.8 to 9% of cases.This frequency of anaphylaxis is the main concern pointed out in many CMA studies.In a review, nearly one third of children with atopic dermatitis (AD) received a diagnosis of CMA after an elimination diet and an oral food challenge, and about 40 to 50% of children less than a year of age with CMA also had AD.Finally, with actual population and geographical trends remaining unknown, allergists are primarily in need of more detailed epidemiological surveys on a global scale.One large such epidemiological study supported by the European Commission is ongoing and aims to furnish the first prevalence data regarding the suspicion of CMA, sensitization to cow's milk, and oral food challenge-confirmed diagnosis in 10 European birth cohorts.TABLE 3-1.Comparison of the Three Main Food Allergens In Children Studies 75

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Metadata

Authors
Fiocchi, A., Brozek, J., Schünemann, H., Bahna, S. L., von Berg, A., Beyer, K., Bozzola, M., Bradsher, J., Compalati, E., Ebisawa, M., Guzman, M. A., Li, H., Heine, R. G., Keith, P., Lack, G., Landi, M., Martelli, A., Rancé, F., Sampson, H., Stein, A., Terracciano, L., & Vieths, S.
Venue
World Allergy Organization Journal
Publisher
Elsevier BV
Published
2010
Volume
3
Issue
4
Pages
57-161
ISSN
1939-4551 (ISSN-L)
OpenAlex
W2107859942
Cited by
644
References
7
FWCI
20.04
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. https://app.cochat.ai/papers/10.1097/wox.0b013e3181defeb9
The paper
Fiocchi, A., Brozek, J., Schünemann, H., Bahna, S. L., von Berg, A., Beyer, K., Bozzola, M., Bradsher, J., Compalati, E., Ebisawa, M., Guzman, M. A., Li, H., Heine, R. G., Keith, P., Lack, G., Landi, M., Martelli, A., Rancé, F., Sampson, H., . . . Vieths, S. (2010). World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. World Allergy Organization Journal. https://doi.org/10.1097/wox.0b013e3181defeb9

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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