Cited by 403Food Allergy and Anaphylaxis ResearchProteins in Food SystemsFood and Agricultural Sciences

Digestibility of Food Allergens and Nonallergenic Proteins in Simulated Gastric Fluid and Simulated Intestinal FluidA Comparative Study

Fu, Tong-Jen, Abbott, Upasana R., Hatzos, Catherine·2002·Journal of Agricultural and Food Chemistry

Abstract

Information on the comparative digestibility of food allergens and nonallergenic proteins is crucial when stability to digestion is to be used as a criterion to assess the allergenic potential of novel proteins. In this work, we compared the digestive stability of a number of food allergens and proteins of unproven allergenicity and examined whether allergens possess a higher stability than nonallergenic proteins of similar cellular functions, and whether there is a correlation between protein digestibility and allergenicity. The stability of groups of storage proteins, plant lectins, contractile proteins, and enzymes, both allergens and proteins with unproven allergenicity, in a standard simulated gastric fluid and a standard simulated intestinal fluid was measured. Food allergens were not necessarily more resistant to digestion than nonallergenic proteins. There was not a clear relationship between digestibility measured in vitro and protein allergenicity.

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Crossref · 10.1021/jf020599h

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Authors
Fu, T.-J., Abbott, U. R., & Hatzos, C.
Affiliations
United States Food and Drug Administration (US)
Venue
Journal of Agricultural and Food Chemistry
Published
2002-10-10
Volume
50
Issue
24
Pages
7154-7160
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W4239393922
Cited by
403
References
21
Citations by year
2026: 5 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 24 · 2018: 17 · 2017: 32 · 2016: 18 · 2015: 17 · 2014: 19 · 2013: 17 · 2012: 19
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Food and Drug Administration (FD000431)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords
food allergens, protein digestibility, digestive stability, simulated gastric fluid, simulated intestinal fluid, protein allergenicity, storage proteins, plant lectins, contractile proteins, enzymes, novel proteins, in vitro digestion
MeSH terms
Allergens, Body Fluids, Dietary Proteins, Digestion, Drug Stability, Electrophoresis, Polyacrylamide Gel, Food Hypersensitivity, Gastric Mucosa, Intestinal Mucosa, Lactoglobulins, Models, Biological, Ovalbumin, Papain, Pepsin A, Plant Lectins

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