Factors predicting adherence to antidepressant treatment
Abstract
PURPOSE OF REVIEW: Poor adherence and discontinuation of treatment are the major challenges of pharmacotherapy among patients with depression. This article reviews the factors predicting adherence to and persistence of antidepressant treatment identified in recent years. RECENT FINDINGS: Study populations have been extended to subgroups of patients with depression or depressive patients with comorbid medical conditions. Some studies have investigated the issues by analysing medical claims databases. Socio-demographic variables, clinical features of depression, comorbidities, pharmacological factors, attitudes towards antidepressants, previous experiences of antidepressant treatment, patient-professional relationship and genes were found to be common factors. An older age, positive attitudes to antidepressants and previous experiences and vicarious experiences of depression or treatment were found to be factors predicting better adherence or persistence. Conversely, patients in minority groups, those with a low family income, pregnancy, experience of side effects, dissatisfaction with treatment and a poor patient-professional relationship were found to be associated with poorer adherence or persistence. SUMMARY: The factors predicting adherence and persistence are complex and interactive. Different methods of studies have limitations in terms of exploring all these factors. Future studies should integrate these factors simultaneously and explore specific factors predicting adherence and persistence among subgroups of patients with depression.
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Up to 43% of patients with major depressive disorder stopped taking antidepressants due to side effects.
“For example, up to 43% of patients with major depressive disorder (MDD) stopped taking antidepressants due to side effects.8”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [8]
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- Authors
- Hung, C.-I.
- Affiliations
- Chang Gung University (TW)
- Corresponding author
- Hung, Ching-I
- ORCID
- Hung, Ching-I
- Venue
- Current Opinion in Psychiatry
- Published
- 2014-09
- Volume
- 27
- Issue
- 5
- Pages
- 344-349
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2317419167
- Cited by
- 88
- References
- 46
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 9 · 2016: 6 · 2014: 2
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- antidepressant adherence, treatment persistence, depression, predictors of treatment adherence, patient-professional relationship, comorbidities, socioeconomic factors, antidepressant side effects, treatment dissatisfaction, minority groups, pregnancy, genetic factors
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Humans, Health Knowledge, Attitudes, Practice, Socioeconomic Factors, Medication Adherence
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