Deep learning applications in vascular dementia using neuroimaging
Abstract
Purpose of review: Vascular dementia (VaD) is the second common cause of dementia after Alzheimer's disease, and deep learning has emerged as a critical tool in dementia research. The aim of this article is to highlight the current deep learning applications in VaD-related imaging biomarkers and diagnosis. Recent findings: The main deep learning technology applied in VaD using neuroimaging data is convolutional neural networks (CNN). CNN models have been widely used for lesion detection and segmentation, such as white matter hyperintensities (WMH), cerebral microbleeds (CMBs), perivascular spaces (PVS), lacunes, cortical superficial siderosis, and brain atrophy. Applications in VaD subtypes classification also showed excellent results. CNN-based deep learning models have potential for further diagnosis and prognosis of VaD. Summary: Deep learning neural networks with neuroimaging data in VaD research represent significant promise for advancing early diagnosis and treatment strategies. Ongoing research and collaboration between clinicians, data scientists, and neuroimaging experts are essential to address challenges and unlock the full potential of deep learning in VaD diagnosis and management.
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DL models detect and segment critical VaD indicators (WMHs, cerebral microbleeds, perivascular spaces, lacunar infarcts, and cortical atrophy) with submillimetre precision.
“These models detect and segment critical VaD indicators [including white matter hyperintensities (WMHs), cerebral microbleeds, perivascular spaces, lacunar infarcts, and cortical atrophy] with submillimetre precision”
From Multimodal neuroimaging and AI integration in cognitive disorders: advances, challenges, and future directions for precision medicine (2026) · cites this paper as Dong and Hayashi, 2024
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- Authors
- Dong, C., & Hayashi, S.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Dong, Chao
- ORCID
- Dong, Chao
- Venue
- Current Opinion in Psychiatry
- Published
- 2023-12-20
- Volume
- 37
- Issue
- 2
- Pages
- 101-106
- ISSN
- 0951-7367 (ISSN-L)
- 1473-6578
- OpenAlex
- W4390919999
- Cited by
- 13
- References
- 67
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- vascular dementia, deep learning, convolutional neural networks, neuroimaging biomarkers, white matter hyperintensities, cerebral microbleeds, perivascular spaces, lacunes, superficial siderosis, brain atrophy, lesion segmentation, dementia diagnosis
- MeSH terms
- Deep Learning, Alzheimer Disease, Brain, Humans, Magnetic Resonance Imaging, Dementia, Vascular, Neuroimaging
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