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Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies

Petitjean, Sylvie, Ladewig, Dieter, Meier, Christoph R., Amrein, Roman, Wiesbeck, Gerhard A.·2007·International Clinical Psychopharmacology

DOI 10.1097/yic.0b013e328105e0f2

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Abstract

UNLABELLED: The purpose of the study was to assess prevalence of benzodiazepine use in the Swiss adult population and to assess on benzodiazepine prescription patterns of physicians in domiciliary practice. STUDY DESIGN: A retrospective, population-based cross-sectional study with 520 000 patients covering a 6-month period. METHODS: We estimated the prevalence, amount and duration of benzodiazepine use using a pharmacy dispensing database. RESULTS: Of all patients, 9.1% (n=45 309) received at least one benzodiazepine prescription in the 6-month period. Most persons receiving benzodiazepine prescriptions were women (67%), and half of all patients were aged 65 or older. Of 45 309 patients with benzodiazepine prescriptions, 44% (n=19 954) had one single prescription, mostly for a short period (<90 days) and in lower than the recommended dose range. Fifty-six percent (n=25 354) had repeated benzodiazepine prescriptions, mostly for a long time period (>90 days), and in lower than the recommended or within the recommended dose range. In patients with long-term use (n=25 354), however, 1.6% had benzodiazepine prescriptions in extremely high doses. The sample of patients with repeated prescriptions allowed an estimation of a benzodiazepine use of 43.3 daily defined doses per 1000 inhabitants in Switzerland. CONCLUSIONS: Benzodiazepine prescriptions were appropriate for most patients and thus were prescribed in therapeutic doses, as indicated in the treatment guidelines. On the other hand, our survey showed that 1.6% of the patients had prescriptions for long time periods at very high doses, indicating an abuse or dependence on benzodiazepines in this subgroup.

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Authors: Petitjean, S., Ladewig, D., Meier, C. R., Amrein, R., & Wiesbeck, G. A.
Affiliations: Universitäre Psychiatrische Kliniken Basel (CH)
University Hospital of Basel (CH)
Corresponding author: Petitjean, Sylvie
ORCID: Meier, Christoph R.
Venue: International Clinical Psychopharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-09
Volume: 22
Issue: 5
Pages: 292-298
ISSN: 0268-1315 (ISSN-L)
DOI: 10.1097/yic.0b013e328105e0f2
OpenAlex: W2053311281
Cited by: 132
References: 22
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 11 · 2020: 22 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 6
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Locations: International Clinical Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesamt für Gesundheit
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: benzodiazepines, benzodiazepine prescribing, prescribing patterns, benzodiazepine misuse, benzodiazepine dependence, long-term benzodiazepine use, community pharmacy dispensing
MeSH terms: Adolescent, Adult, Aged, Benzodiazepines, Cross-Sectional Studies, Dose-Response Relationship, Drug, Drug Utilization, Female, Health Surveys, Humans, Male, Middle Aged, Pharmacies, Drug Prescriptions, Retrospective Studies, Switzerland

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Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies

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