Trends in the consumption rates of benzodiazepines and benzodiazepine-related drugs in the health region of Lleida from 2002 to 2015
Open accessPublished version of a preprint
Abstract
BACKGROUND: The high prevalence and long-term use of benzodiazepines (BZDs) treatment are debated topics because of the risk they can cause to the patients. Despite the current information on the risk-benefit balance of these drugs, their consumption remains particularly high. We determined the trend in the consumption prevalence of benzodiazepines (BZDs) and drugs related to BZDs (Z-drugs) in the population of the Health Region of Lleida to explore patterns of use and the associated characteristics associated between 2002 and 2015. METHODS: An analysis of secular trends was carried out between 2002 and 2015; the databased included all individuals from the Health Region of Lleida, which had 358,157 inhabitants in 2015, that consumed BZDs. The consumption of BZDs was evaluated using prescription billing data from the Public Health System. All types of BZDs and BZD analogues that had been approved by the drug agency were included. Trends by age and sex were investigated. RESULTS: Over the whole study period, a total of 161,125 individuals accounted for 338,148 dispensations. Overall, 59% were women, and the mean age was 56 years. The dispensing prevalence of BZDs use in 2015 was 14.2% overall -18.8% in women and 9.6% in men-and was 36% in those over 65 years. According to the half-life of BZDs, the prevalence of short-intermediate BZD use, intermediate-long BZD use, and Z-drugs use was 9.7, 5.5 and 0.8%, respectively. The evolution of the annual prevalence of BZD dispensing showed a progressive decline, from 15.3% in 2002 to 14.2% in 2015, which was attributed to a decrease in the consumption of intermediate-long half-life BZDs (8.0% vs. 5.5%) and Z-drugs (1.4% vs. 0.8%). CONCLUSION: The dispensing prevalence of BZDs and Z-drugs was high, although a small reduction was observed during this time period. The dispensing prevalence was especially high in the population over 65, despite the risk of cognitive decline and falls. Integral actions are required to lower the BZD prescription rate.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
While some studies have shown a decrease in the prescribing of some drug classes, such as benzodiazepines over time, these decreases have been small and inconsistent across different countries.
“While some studies have shown a decrease in the prescribing of some drug classes, such as benzodiazepines over time [83, 84], these decreases have been small and inconsistent across different countries [85, 86].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [83]
The findings of this review help explain the findings of previous studies that have shown high rates of inappropriate psychotropic prescribing in older people both in care homes and wider settings.
“The findings of this review help explain the findings of previous studies that have shown high rates of inappropriate psychotropic prescribing in older people both in care homes [4–7] and wider settings [83].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [83]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The National Institute for Clinical Excellence
(2001) · Nursing Management · doi:10.7748/nm.8.2.39.s15 · Cited by 3,868 · see citing works
By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13702 · Cited by 2,609 · see citing works
The American Geriatrics Society 2012 Beers Criteria Update Expert Panel (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.03923.x · Cited by 2,578 · see citing works
A review of uses of health care utilization databases for epidemiologic research on therapeutics
Schneeweiß, S., & Avorn, J. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.10.012 · Cited by 1,290 · see citing works
Benzodiazepine Use in the United States
Olfson, M., King, M., & Schoenbaum, M. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1763 · Cited by 786 · see citing works
Anxiety disorders in older adults: a comprehensive review
Wolitzky-Taylor, K. B., Castriotta, N., Lenze, E. J., Stanley, M. A., & Craske, M. G. (2010) · Depression and Anxiety · doi:10.1002/da.20653 · Cited by 726 · see citing works
Benzodiazepines revisited—will we ever learn?
Lader, M. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03563.x · Cited by 573 · see citing works
Ohayon, M. M., & Lader, M. H. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0912 · Cited by 271 · see citing works
Benzodiazepines I: Upping the Care on Downers: The Evidence of Risks, Benefits and Alternatives
Guina, J., & Merrill, B. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7020017 · Cited by 253 · see citing works
Safety of benzodiazepines in the geriatric population
Madhusoodanan, S., & Bogunovic, O. J. (2004) · Expert Opinion on Drug Safety · doi:10.1517/14740338.3.5.485 · Cited by 195 · see citing works
Physicians’ perspectives on prescribing benzodiazepines for older adults: a qualitative study
Cook, J. M., Marshall, R., Masci, C., & Coyne, J. C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-006-0021-3 · Cited by 178 · see citing works
Psychotropic Medication Consumption Patterns in the UK General Population
Ohayon, M. M., Caulet, M., Priest, R. G., & Guilleminault, C. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(97)00238-2 · Cited by 170 · see citing works
Use of Inappropriate Prescription Drugs by Older People
Hanlon, J. T., Schmader, K. E., Boult, C., Artz, M. B., Gross, C. R., Fillenbaum, G. G., Ruby, C. M., & Garrard, J. M. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50004.x · Cited by 166 · see citing works
Patterns and correlates of benzodiazepine use in the French general population
Lagnaoui, R., Depont, F., Fourrier, A., Abouelfath, A., B�gaud, B., Verdoux, H., & Moore, N. D. (2004) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-004-0808-2 · Cited by 160 · see citing works
Park, H., Satoh, H., Miki, A., Urushihara, H., & Sawada, Y. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1955-3 · Cited by 158 · see citing works
Fourrier, A., Letenneur, L., Dartigues, J., Moore, N., & Bégaud, B. (2001) · European Journal of Clinical Pharmacology · doi:10.1007/s002280100326 · Cited by 158 · see citing works
Gould, R. L., Coulson, M. C., Patel, N., Highton-Williamson, E., & Howard, R. J. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.126003 · Cited by 156 · see citing works
Clinical factors influencing the prescription of antidepressants and benzodiazepines:
Demyttenaere, K., Bonnewyn, A., Bruffaerts, R., de Girolamo, G., Gasquet, I., Kovess–Masféty, V., Haro, J. M., & Alonso, J. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.01.011 · Cited by 145 · see citing works
Lopez-Munoz, F. J., Álamo, C., & García‐García, P. (2011) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2011.01.002 · Cited by 145 · see citing works
Linden, M., Lecrubier, Y., Bellantuono, C., Benkert, O., Kisely, S., & Simon, G. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199904000-00007 · Cited by 133 · see citing works
Petitjean, S., Ladewig, D., Meier, C. R., Amrein, R., & Wiesbeck, G. A. (2007) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328105e0f2 · Cited by 132 · see citing works
Huerta, C., Abbing‐Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdóttir, H., Miret, M., Schneider, C., Gil, M., Souverein, P. C., et al. (2015) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3825 · Cited by 130 · see citing works
Long-term benzodiazepine use by elderly people living in the community
Jorm, A. F., Grayson, D. A., Creasey, H. M., Waite, L. M., & Broe, G. A. (2000) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2000.tb00715.x · Cited by 129 · see citing works
GPs’ management strategies for patients with insomnia: A survey and qualitative interview study
Everitt, H., McDermott, L., Leydon, G., Yules, H., Baldwin, D., & Little, P. (2014) · British Journal of General Practice · doi:10.3399/bjgp14x677176 · Cited by 127 · see citing works
Mugunthan, K., McGuire, T., & Glasziou, P. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x593857 · Cited by 123 · see citing works
Weisberg, R. B., DYCK, I. R., Culpepper, L., & Keller, M. B. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.276 · Cited by 120 · see citing works
Ng, B. J., Le Couteur, D. G., & Hilmer, S. N. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0544-4 · Cited by 118 · see citing works
Benzodiazepines: More Behavioural Addiction than Dependence
de las Cuevas, C., Sanz, E., & de la Fuente, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1376-8 · Cited by 113 · see citing works
Sex differences among recipients of benzodiazepines in Dutch general practice.
van der Waals, F. W., Mohrs, J., & Foets, M. (1993) · BMJ · doi:10.1136/bmj.307.6900.363 · Cited by 108 · see citing works
Cook, J. M., Biyanova, T., Masci, C., & Coyne, J. C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0205-5 · Cited by 107 · see citing works
Trends in prescribing of sedative-hypnotic medications in the USA: 1993-2010.
Kaufmann, C. N., Spira, A. P., Alexander, G. C., Rutkow, L., & Mojtabai, R. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3951 · Cited by 105 · see citing works
High concordance between self-reported medication and official prescription database information
Haukka, J. K., Suvisaari, J., Tuulio‐Henriksson, A., & Lönnqvist, J. K. (2007) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-007-0349-6 · Cited by 102 · see citing works
Ten-year trends in benzodiazepine use in the Dutch population
Sonnenberg, C., Bierman, E. J. M., Deeg, D. J. H., Comijs, H. C., van Tilburg, W., & Beekman, A. T. F. (2011) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-011-0344-1 · Cited by 99 · see citing works
Hogan, D. B., Maxwell, C. J., Fung, T. S., & Ebly, E. M. (2003) · PubMed · Cited by 92 · see citing works
The Costs of Benzodiazepine-Associated Hospital-Treated Fall Injuries in the EU: A Pharmo Study
Panneman, M. J. M., Goettsch, W., Kramarz, P., & Herings, R. M. C. (2003) · Drugs & Aging · doi:10.2165/00002512-200320110-00004 · Cited by 89 · see citing works
Long-term use of benzodiazepines and nonbenzodiazepine hypnotics, 1999-2014.
Kaufmann, C. N., Spira, A. P., Depp, C. A., & Mojtabai, R. (2018) · Psychiatric Services · doi:10.1176/appi.ps.201700095 · Cited by 85 · see citing works
Drug utilization statistics for individual-level pharmacy dispensing data
Hallas, J. (2005) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1063 · Cited by 76 · see citing works
Benzodiazepine use in Belgian nursing homes: a closer look into indications and dosages
Bourgeois, J., Elseviers, M. M., Azermai, M., Bortel, L. M. V., Petrović, M., & Stichele, R. V. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1188-z · Cited by 75 · see citing works
Kurko, T., Saastamoinen, L., Tuulio‐Henriksson, A., Taiminen, T. J., Tiihonen, J., Airaksinen, M., & Hietala, J. A. (2018) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4551 · Cited by 73 · see citing works
Mura, T., Proust‐Lima, C., Akbaraly, T. N., Amieva, H., Tzourio, C., Chevassus, H., Picot, M., Jacqmin‐Gadda, H., & Berr, C. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.004 · Cited by 68 · see citing works
Outcome of new benzodiazepine prescriptions to older adults in primary care
Simon, G. E., & Ludman, E. J. (2006) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2006.05.008 · Cited by 67 · see citing works
Use of benzodiazepines and related drugs in Manitoba: a population-based study
Alessi‐Severini, S., Bolton, J. M., Enns, M. W., Dahl, M. E., Collins, D. M., Chateau, D. G., & Sareen, J. (2014) · CMAJ Open · doi:10.9778/cmajo.20130076 · Cited by 66 · see citing works
Sivertsen, B., Nordhus, I. H., Bjorvatn, B., & Pallesen, S. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2009.00769.x · Cited by 66 · see citing works
Chen, L., Bell, J. S., Visvanathan, R., Hilmer, S. N., Emery, T., Robson, L., Hughes, J. M., & Tan, E. C. K. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0363-6 · Cited by 66 · see citing works
Cadogan, C. A., Ryan, C. A., Cahir, C., Bradley, C., & Bennett, K. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13570 · Cited by 66 · see citing works
Trends in Insomnia Diagnosis and Treatment Among Medicare Beneficiaries, 2006–2013
Albrecht, J. S., Wickwire, E. M., Vadlamani, A., Scharf, S. M., & Tom, S. E. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.10.017 · Cited by 65 · see citing works
Takeshima, N., Ogawa, Y., Hayasaka, Y., & Furukawa, T. A. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.040 · Cited by 62 · see citing works
Pek, E., Remfry, A., Pendrith, C., Fan‐Lun, C., Bhatia, R. S., & Soong, C. (2017) · Journal of Hospital Medicine · doi:10.12788/jhm.2739 · Cited by 59 · see citing works
Johnson, C. F. A., Frei, C., Downes, N., McTaggart, S., & Akram, G. (2016) · British Journal of General Practice · doi:10.3399/bjgp16x685213 · Cited by 58 · see citing works
Cloos, J.-M., Bocquet, V., Rolland-Portal, I., Koch, P., & Chouinard, G. (2015) · Psychotherapy and Psychosomatics · doi:10.1159/000434755 · Cited by 57 · see citing works
Kjosavik, S. R., Ruths, S., & Hunskaar, S. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1756 · Cited by 56 · see citing works
Bénard‐Laribière, A., Noïze, P., Pambrun, É., Bazin, F., Verdoux, H., Tournier, M., Bégaud, B., & Pariente, A. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4123 · Cited by 54 · see citing works
Koyama, A. K., Steinman, M. A., Ensrud, K. E., Hillier, T. A., & Yaffe, K. S. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12093 · Cited by 53 · see citing works
Usage patterns of benzodiazepines in a Dutch community: a 10-year follow-up.
van Hulten, R., Leufkens, H. G. M., & Bakker, A. (1998) · Pharmacy World & Science · doi:10.1023/a:1008636707219 · Cited by 51 · see citing works
Dionne, P.-A., Vasiliadis, H., Latimer, E. A., Berbiche, D., & Préville, M. (2012) · Psychiatric Services · doi:10.1176/appi.ps.201200089 · Cited by 51 · see citing works
Benzodiazepine Use in Older Adults in the United States, Ontario, and Australia from 2010 to 2016
Brett, J., Maust, D. T., Bouck, Z., Ignacio, R. V., Mecredy, G. C., Kerr, E. A., Bhatia, S., Elshaug, A. G., & Pearson, S. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15292 · Cited by 49 · see citing works
Clinical distinctions between long-acting and short-acting benzodiazepines.
Mendelson, W. B. (1992) · PubMed · Cited by 48 · see citing works
Gender differences in the use of anxiolytics and antidepressants: a population based study
der Heyden, J. V., Gisle, L., Hesse, E., Demarest, S. S., Drieskens, S., & Tafforeau, J. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1827 · Cited by 48 · see citing works
Psychotropics use in the Spanish elderly: predictors and evolution between years 1993 and 2003
Carrasco‐Garrido, P., Jiménez‐García, R., Astasio, P., Molina, P. O., & de Miguel, Á. G. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1344 · Cited by 48 · see citing works
Préville, M., Bossé, C., Vasiliadis, H., Voyer, P., Laurier, C., Berbiche, D., Pérodeau, G., Grenier, S., Béland, S., Dionne, P.-A., et al. (2012) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980812000232 · Cited by 47 · see citing works
Marra, E. M., Mazer‐Amirshahi, M., Brooks, G., van den Anker, J., May, L., & Pines, J. M. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13666 · Cited by 47 · see citing works
Evolución del uso de medicamentos ansiolíticos e hipnóticos en España durante el período 2000-2011
Sánchez, M. P. V., Saint-Gerons, D. M., Honrubia, C. D. L. F., Bermejo, D. G., Corominas, D. M., & Catalá-López, F. (2013) · Revista Española de Salud Pública · doi:10.4321/s1135-57272013000300004 · Cited by 45 · see citing works
Peterson, J. F., Kripalani, S. B., Danciu, I., Harrell, D., Marvanová, M., Mixon, A. S., Rodriguez, C., & Powers, J. S. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13057 · Cited by 41 · see citing works
Long‐term Use of Z‐Hypnotics and Co‐medication with Benzodiazepines and Opioids
Sakshaug, S., Handal, M., Hjellvik, V., Berg, C., Ripel, Å., Gustavsen, I., Mørland, J. G., & Skurtveit, S. O. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12684 · Cited by 33 · see citing works
Brandt, J., Alessi‐Severini, S., Singer, A. G., & Leong, C. (2019) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.22374/1710-6222.26.1.3 · Cited by 32 · see citing works
Dependence on Prescription Benzodiazepines and Z-drugs Among Young to Middle-aged Patients in France
Guerlais, M., Grall‐Bronnec, M., Feuillet, F., Gérardin, M., Jolliet, P., & Victorri‐Vigneau, C. (2014) · Substance Use & Misuse · doi:10.3109/10826084.2014.980952 · Cited by 29 · see citing works
Nordfjærn, T. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.05.017 · Cited by 26 · see citing works
Benzodiazepine use in Denmark 1997–2008
Holm, E., Fosbøl, E. L., Pedersen, H., Jensen, T. B., Nielsen, M. B., Weeke, P. E., Brinth, L. S., & Torp-Pedersen, C. (2012) · European Geriatric Medicine · doi:10.1016/j.eurger.2012.04.007 · Cited by 25 · see citing works
Discontinuation of Chronic Benzodiazepine Use Among Adults in the United States
Gerlach, L. B., Strominger, J., Kim, H. M., & Maust, D. T. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-05098-0 · Cited by 22 · see citing works
Batty, G. M., Hooper, R., Oborne, C. A., & Jackson, S. H. (2001) · British Journal of Clinical Governance · doi:10.1108/14664100110408608 · Cited by 19 · see citing works
Fond, G. B., Fajula, C., Dassa, D., Brunel, L., Lançon, C., & Boyer, L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4312-z · Cited by 19 · see citing works
Trajectory analysis of anxiolytic dispensing over 10 years among new users aged 50 and older
Verger, P., Mrenda, B. M., Cortaredona, S., Tournier, M., & Verdoux, H. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12858 · Cited by 19 · see citing works
Variation in benzodiazepine and antipsychotic use in people aged 65 years and over in New Zealand.
Jackson, G., Gerard, C., Minko, N., & Parsotam, N. (2014) · PubMed · Cited by 17 · see citing works
Caro-Mendivelso, J., J-M., E.-R., Hermosilla, E., Méndez-Boo, L., García-Gil, M., Prieto‐Alhambra, D., & Medina, M. (2015) · Journal of Epidemiological Research · doi:10.5430/jer.v2n1p80 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.595584 · Cited by 440 · see citing works
GABAergic implications in anxiety and related disorders
Arora, I., Mal, P., Arora, P., Paul, A., & Kumar, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150218 · Cited by 68 · see citing works
Alabaku, O., Yang, A., Tharmarajah, S., Suda, K. J., Vigod, S. N., & Tadrous, M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284389 · Cited by 63 · see citing works
Begum, M., González‐Chica, D. A., Bernardo, C., Woods, A., & Stocks, N. (2021) · British Journal of General Practice · doi:10.3399/bjgp.2021.0054 · Cited by 59 · see citing works
Torres-Bondia, F. I., de Batlle, J., Galván, L., Butı́, M., Barbé, F., & Piñol‐Ripoll, G. (2022) · BMC Public Health · doi:10.1186/s12889-022-13217-6 · Cited by 50 · see citing works
Self-citationBaré, M., Lleal, M., Roig, S. O., Gorgas, M. Q., Sevilla‐Sánchez, D., Carballo, N., de Jaime, E., Herranz, S., & on behalf of the MoPIM study group (2022) · BMC Geriatrics · doi:10.1186/s12877-021-02715-8 · Cited by 43 · see citing works
Seifert, J., Engel, R. R., Bernegger, X., Führmann, F., Bleich, S., Stübner, S., Sieberer, M. G., Greil, W., Toto, S., & Grohmann, R. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.073 · Cited by 37 · see citing works
Benzodiazepine and Z-Drug Use and the Risk of Developing Dementia
Torres-Bondia, F. I., Dakterzada, F., Galván, L., Butı́, M., Besanson, G., Grill, E., Buil, R., de Batlle, J., & Piñol‐Ripoll, G. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab073 · Cited by 32 · see citing works
Self-citationEfficient and ecofriendly cellulose-supported MIL-100(Fe) for wastewater treatment
Taherzade, S. D., Abbasichaleshtori, M., & Soleimannejad, J. (2022) · RSC Advances · doi:10.1039/d1ra08949h · Cited by 32 · see citing works
Potentially Inappropriate Medication Use in Patients with Dementia
Yoon, K., Kim∥, J. T., Kwack, W.-G., Kim, D.-H., Lee, K., Yang, S., Lee, S., Choi, Y. J., & Chung, E. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191811426 · Cited by 30 · see citing works
Stakeholders' views on the use of psychotropic medication in older people: a systematic review
Bednarczyk, E., Cook, S., Brauer, R., & Garfield, S. (2022) · Age and Ageing · doi:10.1093/ageing/afac060 · Cited by 22 · see citing works
Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options
Garakani, A., Murrough, J. W., Freire, R. C. R., Thom, R. P., Larkin, K., Buono, F. D., & Iosifescu, D. V. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19203 · Cited by 27 · see citing works
Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam
Macedo, J., Marques, R., Vervaet, C., & Pinto, J. F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020538 · Cited by 20 · see citing works
Trends in Prescriptions for Insomnia in a Province in China Between 2015 and 2019
Lou, G., Yu, Z., Chen, L., Zhou, Y., & Zhang, L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.915823 · Cited by 20 · see citing works
Coteur, K., Mamouris, P., Vaes, B., Nuland, M. V., Matheï, C., & Schoenmakers, B. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1014734 · Cited by 20 · see citing works
Bojanić, I. (2024) · Depression and Anxiety · doi:10.1155/2024/5448587 · Cited by 18 · see citing works
A Need for Benzodiazepine Deprescribing in the COVID-19 Pandemic: A Cohort Study
Bužančić, I., Pejaković, T. I., & Hadžiabdić, M. O. (2022) · Pharmacy · doi:10.3390/pharmacy10050120 · Cited by 14 · see citing works
Bezabhe, W. M. M., Radford, J. C., Salahudeen, M. S., Bindoff, I. K., Ling, T. R., Gee, P. R., Wimmer, B. C., & Peterson, G. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12103389 · Cited by 14 · see citing works
Carton, L., Niot, C., Kyheng, M., Pétrault, M., Laloux, C., Potey, C., Lenski, M., Bordet, R., & Deguil, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01718-8 · Cited by 13 · see citing works
Okui, T., Park, J., Hirata, A., & Nakashima, N. (2021) · Healthcare · doi:10.3390/healthcare9121724 · Cited by 13 · see citing works
Arenas, M. B., Arroyo-Sánchez, A., Torres-Parejo, Ú., & Muñoz-Negro, J. E. (2025) · International Journal of Social Psychiatry · doi:10.1177/00207640251331898 · Cited by 12 · see citing works
Revisiting benzodiazepines (GABA Enhancers):A transdiagnostic and precision medicine approach
Pallanti, S., Zohar, J., Kasper, S. F., Möller, H., & Hollander, E. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.042 · Cited by 12 · see citing works
Sáenz-Herrero, M., Recio-Barbero, M., López-Atanes, M., Santorcuato, A., Amaia Bacigalupe, H., & Segarra, R. (2023) · Archives of Women s Mental Health · doi:10.1007/s00737-023-01360-x · Cited by 10 · see citing works
Roncero, C., Armenteros, L., Bellido-Cambrón, C., Guijarro, A. B., & Cibeira, E. G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1547488 · Cited by 11 · see citing works
Mortier, P., Vilagut, G., García‐Mieres, H., Alayo, I., Ferrer, M., Amigo, F., Aragonès, E., Peña, A. A., Asúnsolo, Á., Campos, M., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115800 · Cited by 12 · see citing works
González‐Chica, D. A., Begum, M., Bernardo, C., Hoon, E. A., Sweetman, A., & Stocks, N. (2022) · Drug and Alcohol Review · doi:10.1111/dar.13561 · Cited by 8 · see citing works
Sleep quality among inpatients of Spanish public hospitals
Bellon, F., Stremler, R., Rubinat, E., Padilla‐Martínez, J. M., Casado‐Ramírez, E., Sánchez-Ortuño, M. M., Gea‐Sánchez, M., Martín-Vaquero, Y., Moreno‐Casbas, T., & Abad‐Corpa, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-26412-7 · Cited by 8 · see citing works
Trends in Benzodiazepine and Z-Drug Prescriptions in Eastern China (2015–2021)
Deng, Q., & Chen, H. (2025) · ALPHA PSYCHIATRY · doi:10.31083/ap38792 · Cited by 7 · see citing works
Upotreba anksiolitika kod studenata medicine na Medicinskom fakultetu u Osijeku
Odjel za internu medicinu, N. M. B. V., Marušić, R., Medicinski fakultet, S. J. J. S. U. O., Karl, D., Medicinski fakultet, S. J. J. S. U. O., Olujić, M., Medicinski fakultet, S. J. J. S. U. O., Oftalmološka klinika dr. Balog, O., Jurić, P., Medicinski fakultet, S. J. J. S. U. O., et al. (2023) · Socijalna psihijatrija · doi:10.24869/spsih.2022.373 · Cited by 7 · see citing works
Does fasting in Ramadan increase the risk of traffic accidents? A time series analysis
Zohrevandi, B., Rad, E. H., Normohamadi, N. S., Shahnazari, S., Monsef-Kasmaei, B., & Khodadadi‐Hassankiadeh, N. (2025) · BMC Public Health · doi:10.1186/s12889-025-21980-5 · Cited by 6 · see citing works
Use of Pharmacogenetics for Benzodiazepine Prescription: State of the Art and Expectations
Zubiaur, P., & Abad‐Santos, F. (2022) · Pharmacogenomics · doi:10.2217/pgs-2022-0161 · Cited by 6 · see citing works
Use of Benzodiazepines and Z-Drugs in Multiple Sclerosis
Marrie, R. A., Fisk, J. D., Walld, R., Bolton, J. M., Sareen, J., Patten, S. B., Singer, A. G., Lix, L. M., Hitchon, C. A., El-Gabalawy, R. M., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.874724 · Cited by 6 · see citing works
Čop, K. T., Gotovuša, M., Pavlović, D. M., Dabić, D., & Grčić, I. (2025) · Nanomaterials · doi:10.3390/nano15110827 · Cited by 5 · see citing works
Munkholm, K., Ussing, A., Brink, M., Edemann-Callesen, H., Canbolat, S. S., Christensen, R., Dahl, K. S., Ebdrup, B. H., Jensen, M. E. J., Kierulf-Lassen, C., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01680-0 · Cited by 5 · see citing works
Medarević, A. (2022) · Glasnik javnog zdravlja · doi:10.5937/serbjph2202126m · Cited by 5 · see citing works
Lundqvist, C., Simonsen, T. B., & Siddiqui, T. (2025) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2025.2475300 · Cited by 4 · see citing works
Marin, G. H., Mauro, J. S. D., Marín, L., Urtasun, M. A., Marin, G., Nucher, D., Dacher, C., Perez, D. D., & Cañás, M. (2021) · Salud Colectiva · doi:10.18294/sc.2021.3583 · Cited by 3 · see citing works
Utilization of psychotropic medicines in Romania during 1998–2018
Iaru, I., Bucșa, C., Farcas, A. M., Pop, C., Cristina, A., Armean, S. M., Brumboiu, I., Voștinaru, O., & Mogoșan, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1157231 · Cited by 4 · see citing works
Sousa, G. D. S., Mendonça, R. V. D. M., Anna, C. D. C. S., & de Almeida, M. K. C. (2020) · Revista Amazônica de Ciências Farmacêuticas · doi:10.17648/2675-5572.racf.v1n1.2-4 · Cited by 4 · see citing works
Lleal, M., Baré, M., Roig, S. O., Sevilla‐Sánchez, D., Jordana, R., Herranz, S., Gorgas, M. Q., Espaulella-Ferrer, M., Arellano, M., de Antonio, M., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315902 · Cited by 4 · see citing works
A Case-Control Study of Accidental Falls During Surgical Hospitalizations
Morales, D. J. V., Laporta, M. L., Johnson, R. L., Schroeder, D. R., Šprung, J., & Weingarten, T. N. (2021) · The American Surgeon · doi:10.1177/00031348211011114 · Cited by 4 · see citing works
Long-term benzodiazepine prescriptions in community psychiatry clinics
Tau, M. A., Moosa, M. Y. H., & Jeenah, F. Y. (2024) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v30i0.2181 · Cited by 3 · see citing works
Tiihonen, R., Paattiniemi, E. L., Nurmi-Lüthje, I., Naboulsi, H., Pigg, S., Kataja, M., Sarkkinen, H., Kaukonen, J.-P., & Lüthje, P. M. J. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104209 · Cited by 3 · see citing works
Alwafi, H. H. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.06.003 · Cited by 3 · see citing works
Eid, H. M. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Fawzy, M. N., Papadakis, M., Almutawif, Y. A., Alexiou, A. T., & Batiha, G. E. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156976 · Cited by 3 · see citing works
Stefani, L., Mineo, F., Romani, L., Vernich, F., Russo, C., Marsella, L. T., & Tittarelli, R. (2024) · Separations · doi:10.3390/separations11060169 · Cited by 2 · see citing works
Tarhini, Z., Magné, J., Preux, P., Parenté, A., Mathonnet, M., Christou, N., & Jost, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115950 · Cited by 2 · see citing works
Guo, W., Zhang, C., Yang, R., & Liang, Y. (2025) · Medicine · doi:10.1097/md.0000000000044797 · Cited by 1 · see citing works
López, I. F., Lima, A. O. D. L., Gutiérrez‐Valencia, A., Bermúdez, E. G., Martín, F. A., Morente, A. G.-D., Fernández, M. D. M., Cañete, Y. S., & Bermúdez‐Tamayo, C. (2025) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2025.100666 · Cited by 1 · see citing works
Couto, I. S., Sgnaolin, V., Engroff, P., Dannebrock, L. G., Guilhermano, L. G., & Neto, A. C. (2021) · PAJAR - Pan-American Journal of Aging Research · doi:10.15448/2357-9641.2021.1.40298 · Cited by 1 · see citing works
Estudo do uso de Benzodiazepínicos em Instituição pública de Teresina-PI
Batista, G. D. V., Santos, G. D. D. S., & da Silva, W. C. (2022) · Research Society and Development · doi:10.33448/rsd-v11i1.24839 · Cited by 1 · see citing works
Widinghoff, C., Berge, J., & Håkansson, A. (2021) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-021-00636-6 · Cited by 1 · see citing works
Sáenz-Herrero, M., Recio-Barbero, M., López-Atanes, M., Santorcuato, A., Amaia Bacigalupe, H., & Segarra, R. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4165643
Yong, S. L., Tan, H. J. R., Chemi, N. B., Mokhtar, S. S. S., Yee, W. N., Zamri, N. M. B. M., Sahidan, E. B., & Sue, K. T. (2022) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.18.6.26
Bansal, P., Saini, B., Bansal, P. D., Bansal, A., Dhillon, J. S., Kaur, V., Singh, G., & Saini, S. (2023) · Indian Journal of Community Medicine · doi:10.4103/ijcm.ijcm_618_22
Research on the neural circuits and treatment of anxiety
Cai, Y. (2023) · Theoretical and Natural Science · doi:10.54254/2753-8818/24/20231122
RAI, J., PANDEY, A., Haider, J., & MISHRA, S. S. (2025) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2025v18i5.54402
Mansour, A. R., Thobias, J. M., Yondu, E., Philipo, E. G., Mikomangwa, W. P., Kilonzi, M., Marealle, A. I., & Mutagonda, R. F. (2025) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/1404995
Long-Term Benzodiazepine Consumption and Its Repercussions on Aged Brain Performance
Prabavathy, S., Salahuddin, S., Singh, T., Ramu, N., Pattnaik, S., & Dhingra, L. (2025) · Health Leadership and Quality of Life · doi:10.56294/hl2025597
Baré, M., Lleal, M., Roig, S. O., Gorgas, M. Q., Sevilla‐Sánchez, D., Carballo, N., De Jaime, E., & Herranz, S. (2022) · Figshare · doi:10.6084/m9.figshare.18230677
Torres-Bondia, F. I., de Batlle, J., Galván, L., Buti, M., Barbé, F., & Piñol‐Ripoll, G. (2022) · Figshare · doi:10.6084/m9.figshare.19643444
Self-citationUse of benzodiazepines in primary care: prescriptions from 2010 to 2019 in Catalonia
Also, M. A., Murgui, S., Sant, E., Sans-Corrales, M., Sisó‐Almirall, A., Mas, A., Valenzuela‐Pascual, C., Anmella, G., Blanch, J., Cavero, M., et al. (2026) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2026.100341
ASSOCIAÇÃO DO USO DE BENZODIAZEPÍNICOS E ALTERAÇÕES COGNITIVAS
Felippe, C. J., Bauer, I. D. P., Batista, G., Salvaro, M. C., & Bruch, T. P. (2026) · Arquivos Catarinenses de Medicina · doi:10.63845/8e6her25
Cost-utility analysis of benzodiazepine deprescription in primary care: a cohort study
López, I. F., Špacírová, Z., Lima, A. O. D. L., Gutierrez-Valencia, A., Sayago, M. F., Celdran, M. M., Bernal, M. A. S., & Bermúdez‐Tamayo, C. (2026) · BMC Health Services Research · doi:10.1186/s12913-026-14149-2
Seijas‐Amigo, J. (2026) · Discover Public Health · doi:10.1186/s12982-026-02922-x
Aranda, B. B., Aznar-Lou, I., Peñarrubia-María, M., Rosell, E. C., Puig-García, M., Lumbreras, B., López-Pintor, E., Pérez, A. B., & Parker, L. A. (2026) · BMJ public health · doi:10.1136/bmjph-2025-004639
Kusturica, M. P., Peñarrubia‐María, M. T., Parker, L. A., Mucherino, S., Menditto, E., Orlando, V., & Aznar‐Lou, I. (2026) · Drugs & Aging · doi:10.1007/s40266-026-01340-7
- Authors
- Torres-Bondia, F., de Batlle, J., Galván, L., Buti, M., Barbé, F., & Piñol-Ripoll, G.
- Affiliations
- Hospital Universitari Arnau de Vilanova (ES)
- ORCID
- Venue
- BMC Public Health
- Published
- 2020-06-01
- Volume
- 20
- Issue
- 1
- Pages
- 818-818
- ISSN
- 1471-2458 (ISSN-L)
- PMC
- PMC7268471
- OpenAlex
- W3032035778
- Cited by
- 69
- References
- 75
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 5 · 2023: 12 · 2022: 20 · 2021: 10 · 2020: 4
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Public Health (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, cc-by)
- Repositori ObertUDL (University of Lleida) (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Generalitat de Catalunya (PERIS 2016: SLT002/16/00364)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- benzodiazepines, Z-drugs, drug use trends, sex differences in drug use, age differences in drug use, medication dispensing, long-term benzodiazepine use
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Benzodiazepines, Drug Utilization, Female, Forecasting, Humans, Hypnotics and Sedatives, Male, Middle Aged, Practice Patterns, Physicians', Spain, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
