Multiscale modelling of insulin secretion during an intravenous glucose tolerance test
Open accessAbstract
Dysfunctional insulin secretion from pancreatic β-cells plays a major role in the development of diabetes. The intravenous glucose tolerance test (IVGTT) is a widely used clinical test to assess β-cell function. The analysis of IVGTT data is conveniently performed using mathematical models, which need to be fairly simple to enable parameter identifiability (minimal models), but should at the same time have sound biological foundation at the cellular level. Using mathematical analysis and model reduction, we show here that our recent mathematical model of insulin secretory granule dynamics in β-cells provides mechanistic underpinning for our minimal model of pancreatic insulin secretion during an IVGTT.
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Current models of diabetes pathogenesis typically place feedback interactions between glucose and insulin at the core of glycaemic control.
“Current models of the pathogenesis of diabetes typically place the feedback interactions between glucose and insulin at the core of glycaemic control ( 17, 25 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [25]
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- Authors
- Pedersen, M. G., & Cobelli, C.
- Affiliations
- University of Padua (IT)
- Venue
- Interface Focus
- Publisher
- The Royal Society
- Published
- 2013-04-06
- Volume
- 3
- Issue
- 2
- Pages
- 20120085
- ISSN
- 2042-8898 (ISSN-L)
- 2042-8901
- PMC
- PMC3638483
- OpenAlex
- W2156157884
- Cited by
- 11
- References
- 26
- Citations by year
- 2026: 2 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Interface Focus (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- insulin secretion, pancreatic beta cells, intravenous glucose tolerance test, minimal models, insulin secretory granules, model reduction, multiscale modeling, beta-cell dysfunction, diabetes mellitus, parameter identifiability
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