Cited by 46Diabetes Management and ResearchPancreatic function and diabetesHistory of Science and Medicine

Advancing Our Understanding of the Glucose System via Modeling: A Perspective

Cobelli, Claudio, Dalla Man, Chiara, Pedersen, Morten Gram, Bertoldo, Alessandra, Toffolo, Gianna·2014·IEEE Transactions on Biomedical Engineering

Abstract

The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents. Tracers and compartmental models allowed moving to the first quantitative pictures of the system and stimulated important developments in terms of modeling methodology. Three classes of multiscale models, models to measure, models to simulate, and models to control the glucose system, are reviewed in their historical development with an eye to the future.

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Crossref · 10.1109/tbme.2014.2310514

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144 of 144 references verified0 citation errors · 0 not checkable

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  • Several models have re-examined physiological and clinical data from a dynamical perspective to shed light on mechanisms leading to diabetes, with uncompensated insulin resistance at their core.

    “several models ( 17-19 ) have re-examined physiological and clinical data from a dynamical perspective to shed light on the mechanisms leading to diabetes, with uncompensated insulin resistance at their core ( 20, 21 ).”

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Authors
Cobelli, C., Dalla Man, C., Pedersen, M. G., Bertoldo, A., & Toffolo, G.
Affiliations
University of Padua (IT)
Venue
IEEE Transactions on Biomedical Engineering
Published
2014-05
Volume
61
Issue
5
Pages
1577-1592
ISSN
  • 0018-9294 (ISSN-L)
  • 1558-2531
OpenAlex
W2048014456
Cited by
46
References
145
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 7 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 2
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • IEEE Transactions on Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
FP7 EU Project AP@home, Italian Ministero dell¿Univerisità e della Ricerca project FIRB 2008, Juvenile Diabetes Research Foundation Simulation Core Facility Grant
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
Keywords
glucose homeostasis, compartmental model, tracer kinetics, multiscale modeling, insulin, glycogen, milieu intérieur, glucose regulation
MeSH terms
Blood Glucose, Computer Simulation, Diabetes Mellitus, Humans, Insulin, Models, Biological, Organ Specificity, Pancreas, Artificial, Biomedical Research, History, 19th Century, History, 20th Century, History, 21st Century

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