The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The effect of geometry on three-dimensional tissue growth
Open accessAbstract
Tissue formation is determined by uncountable biochemical signals between cells; in addition, physical parameters have been shown to exhibit significant effects on the level of the single cell. Beyond the cell, however, there is still no quantitative understanding of how geometry affects tissue growth, which is of much significance for bone healing and tissue engineering. In this paper, it is shown that the local growth rate of tissue formed by osteoblasts is strongly influenced by the geometrical features of channels in an artificial three-dimensional matrix. Curvature-driven effects and mechanical forces within the tissue may explain the growth patterns as demonstrated by numerical simulation and confocal laser scanning microscopy. This implies that cells within the tissue surface are able to sense and react to radii of curvature much larger than the size of the cells themselves. This has important implications towards the understanding of bone remodelling and defect healing as well as towards scaffold design in bone tissue engineering.
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Cites
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Taniguchi, N., Fujibayashi, S., Takemoto, M., Sasaki, K., Otsuki, B., Nakamura, T., Matsushita, T., Kokubo, T., & Matsuda, S. (2016) · Materials Science and Engineering: C · doi:10.1016/j.msec.2015.10.069 · Cited by 960
Bobbert, F. S. L., Lietaert, K., Eftekhari, A. A., Pouran, B., Ahmadi, S. M., Weinans, H., & Zadpoor, A. A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.024 · Cited by 873
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
Ma, H., Feng, C., Chang, J., & Wu, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.026 · Cited by 512
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Metadata
- Authors
- Rumpler, M., Woesz, A., Dunlop, J. W. C., van Dongen, J. T., & Fratzl, P.
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2008-03-18
- Volume
- 5
- Issue
- 27
- Pages
- 1173-1180
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- OpenAlex
- W2125170987
- Cited by
- 531
- References
- 35
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rumpler, M., Woesz, A., Dunlop, J. W. C., van Dongen, J. T., & Fratzl, P. (2008). The effect of geometry on three-dimensional tissue growth. Journal of The Royal Society Interface. https://doi.org/10.1098/rsif.2008.0064
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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