The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds
Open accessAbstract
This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibility of designing multifunctional three-dimensional bone TE scaffolds for the emerging field of bone TE therapeutics is discussed. A detailed summary of drugs included in three-dimensional scaffolds and the several approaches developed to combine bioceramics with various polymeric biomaterials in composites for drug-delivery systems is included. The main results presented in the literature are discussed and the remaining challenges in the field are summarized with suggestions for future research directions.
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Nancollas, G. H., Tang, R., Phipps, R. J., Henneman, Z., Gulde, S., Wu, W., Mangood, A., Russell, R. G. G., & Ebetino, F. H. (2006) · Bone · doi:10.1016/j.bone.2005.05.003 · Cited by 862
Drug/device combinations for local drug therapies and infection prophylaxis
Wu, P., & Grainger, D. W. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.11.031 · Cited by 491
In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants
Ramchandani, M., & Robinson, D. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00113-2 · Cited by 195
Cited by
Recent advances in biomaterials for 3D scaffolds: A review
Nikolova, M. P., & Chavali, M. S. (2019) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.10.005 · Cited by 907
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
De Witte, T.-M., Fratila-Apachitei, L. E., Zadpoor, A. A., & Peppas, N. A. (2018) · Regenerative Biomaterials · doi:10.1093/rb/rby013 · Cited by 513
Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review
Rai, R., Tallawi, M., Grigore, A., & Boccaccini, A. R. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.02.001 · Cited by 477
Self-citationMouriño, V., Cattalini, J. P., & Boccaccini, A. R. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0611 · Cited by 441
Self-citationFernandes, H. R., Gaddam, A., Rebelo, A., Brazete, D., Stan, G. E., & Ferreira, J. M. F. (2018) · Materials · doi:10.3390/ma11122530 · Cited by 397
Metadata
- Authors
- Mouriño, V., & Boccaccini, A. R.
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2009-10-28
- Volume
- 7
- Issue
- 43
- Pages
- 209-227
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- OpenAlex
- W2166218291
- Cited by
- 527
- References
- 3
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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