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A comparative analysis of synthetic genetic oscillators
Open accessAbstract
Synthetic biology is a rapidly expanding discipline at the interface between engineering and biology. Much research in this area has focused on gene regulatory networks that function as biological switches and oscillators. Here we review the state of the art in the design and construction of oscillators, comparing the features of each of the main networks published to date, the models used for in silico design and validation and, where available, relevant experimental data. Trends are apparent in the ways that network topology constrains oscillator characteristics and dynamics. Also, noise and time delay within the network can both have constructive and destructive roles in generating oscillations, and stochastic coherence is commonplace. This review can be used to inform future work to design and implement new types of synthetic oscillators or to incorporate existing oscillators into new designs.
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Cites
Foundations for engineering biology
Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511
Design principles of biochemical oscillators
Novák, B., & Tyson, J. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2530 · Cited by 1,137
Next-generation synthetic gene networks
Lu, T. K., Khalil, A. S., & Collins, J. J. (2009) · Nature Biotechnology · doi:10.1038/nbt.1591 · Cited by 365
Smolen, P., Baxter, D. A., & Byrne, J. H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c531 · Cited by 185
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Agent-based modelling in synthetic biology
Gorochowski, T. E. (2016) · Essays in Biochemistry · doi:10.1042/ebc20160037 · Cited by 86
Bayesian design of synthetic biological systems
Barnes, C. P., Silk, D., Sheng, X., & Stumpf, M. P. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017972108 · Cited by 90
Metadata
- Authors
- Purcell, O., Savery, N. J., Grierson, C. S., & di Bernardo, M.
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2010-06-30
- Volume
- 7
- Issue
- 52
- Pages
- 1503-1524
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- OpenAlex
- W2164198234
- Cited by
- 192
- References
- 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Purcell, O., Savery, N. J., Grierson, C. S., & di Bernardo, M. (2010). A comparative analysis of synthetic genetic oscillators. Journal of The Royal Society Interface. https://doi.org/10.1098/rsif.2010.0183
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