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Antibiotic-decorated titanium with enhanced antibacterial activity through adhesive polydopamine for dental/bone implant
Open accessAbstract
Implant-associated infections, which are normally induced by microbial adhesion and subsequent biofilm formation, are a major cause of morbidity and mortality. Therefore, practical approaches to prevent implant-associated infections are in great demand. Inspired by adhesive proteins in mussels, here we have developed a novel antibiotic-decorated titanium (Ti) material with enhanced antibacterial activity. In this study, Ti substrate was coated by one-step pH-induced polymerization of dopamine followed by immobilization of the antibiotic cefotaxime sodium (CS) onto the polydopamine-coated Ti through catechol chemistry. Contact angle measurement and X-ray photoelectron spectroscopy confirmed the presence of CS grafted on the Ti surface. Our results demonstrated that the antibiotic-grafted Ti substrate showed good biocompatibility and well-behaved haemocompatibility. In addition, the antibiotic-grafted Ti could effectively prevent adhesion and proliferation of Escherichia coli (Gram-negative) and Streptococcus mutans (Gram-positive). Moreover, the inhibition of biofilm formation on the antibiotic-decorated Ti indicated that the grafted CS could maintain its long-term antibacterial activity. This modified Ti substrate with enhanced antibacterial activity holds great potential as implant material for applications in dental and bone graft substitutes.
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“The resulting PDA–AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [66]
In the citing paper
“Importantly, the presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.31,66,67”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [66]
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Metadata
- Authors
- He, S., Zhou, P., Wang, L., Xiong, X., Zhang, Y., Deng, Y., & Wei, S.
- Affiliations
- Peking University (CN)
- Capital Medical University (CN)
- Corresponding author
- Deng, Yi
- Wei, Shicheng
- Venue
- Journal of The Royal Society Interface
- Publisher
- The Royal Society
- Published
- 2014-06-06
- Volume
- 11
- Issue
- 95
- Pages
- 20140169
- ISSN
- 1742-5662 (ISSN-L)
- 1742-5689
- PMC
- PMC4006258
- OpenAlex
- W2137999805
- Cited by
- 142
- References
- 59
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 18 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 14 · 2015: 4 · 2014: 1
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of The Royal Society Interface (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- polydopamine coating, cefotaxime sodium, antibacterial activity, implant-associated infection, biofilm inhibition, bacterial adhesion, catechol chemistry, dental implants, bone implants, hemocompatibility, biocompatibility, Escherichia coli, Streptococcus mutans
- MeSH terms
- Anti-Bacterial Agents, Bacterial Adhesion, Cefotaxime, Escherichia coli, Humans, Materials Testing, Streptococcus mutans, Titanium, Dental Implants, Biofilms, Coated Materials, Biocompatible
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