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Proteomic profiling of archaeological human bone

Sawafuji, Rikai, Cappellini, Enrico, Nagaoka, Tomohito, Fotakis, Anna K., Jersie-Christensen, Rosa Rakownikow, Olsen, Jesper V., Hirata, Kazuaki, Ueda, Shintaroh·2017·Royal Society Open Science
DOI 10.1098/rsos.161004PMC PMC5493901
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Abstract

Ancient protein analysis provides clues to human life and diseases from ancient times. Here, we performed shotgun proteomics of human archeological bones for the first time, using rib bones from the Hitotsubashi site (AD 1657–1683) in Tokyo, called Edo in ancient times. The output data obtained were analysed using Gene Ontology and label-free quantification. We detected leucocyte-derived proteins, possibly originating from the bone marrow of the rib. Particularly prevalent and relatively high expression of eosinophil peroxidase suggests the influence of infectious diseases. This scenario is plausible, considering the overcrowding and unhygienic living conditions of the Edo city described in the historical literature. We also observed age-dependent differences in proteome profiles, particularly for proteins involved in developmental processes. Among them, alpha-2-HS-glycoprotein demonstrated a strong negative correlation with age. These results suggest that analysis of ancient proteins could provide a useful indicator of stress, disease, starvation, obesity and other kinds of physiological and pathological information.

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  • Archeological bone can contain proteins associated with immune responses, such as leukocyte-derived proteins.

    “Archeological bone can contain proteins associated with immune responses, such as leukocyte-derived proteins”

    From Ancient protein analysis in archaeology (2021) · cites this paper as [60]

  • Alpha-2-HS-glycoprotein abundance shows a significant negative correlation with biological age in archaeological human bone.

    “Sawafuji et al. (60) examined the abundance of alpha-2-HS-glycoprotein as a function of biological age, showing a significant negative correlation in this protein’s abundance with biological age”

    From Ancient protein analysis in archaeology (2021) · cites this paper as [60]

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Metadata

Authors
Sawafuji, R., Cappellini, E., Nagaoka, T., Fotakis, A. K., Jersie-Christensen, R. R., Olsen, J. V., Hirata, K., & Ueda, S.
Affiliations
  • Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
  • Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, ster Voldgade 5–7, 1350 Copenhagen, Denmark
  • Department of Anatomy, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
  • Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark
ORCID
Ueda, Shintaroh
Venue
Royal Society Open Science
Publisher
The Royal Society
Published
2017-06
Volume
4
Issue
6
Pages
161004
ISSN
2054-5703
DOI
10.1098/rsos.161004
PMC
PMC5493901
Cited by
117
References
3
Language
en
Licence
royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Funders
Japan Society for the Promotion of Science

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