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The connexin43 gene is responsive to oestrogen
Abstract
Connexin43 is the major protein of gap junctions in heart and smooth muscle including the myometrium. Molecular cloning of the connexin43 gene reveals a similar organization to that exhibited by other connexin genes: the 5' untranslated region is interrupted by an 8.5 kilobase intron. The promoter region preceding the first exon contains a TATA box and AP-1 and AP-2 sites. In addition, a series of half-palindromic oestrogen response elements is present in this region. When this promoter is linked to the reporter gene luciferase, it drives the expression of luciferase constitutively in HeLa cells transfected with this luciferase-connexin43 promoter fusion construct. When the same cells are cotransfected with oestrogen receptor cDNA, an upregulation of luciferase expression by oestrogen occurs in a cell-specific manner.
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Cited by
Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling
Bruzzone, R., White, T. W., & Paul, D. L. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0001q.x · Cited by 1,302
Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome
Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U., & Söhl, G. (2002) · Biological Chemistry · doi:10.1515/bc.2002.076 · Cited by 1,158
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995
Gabriels, J. E., & Paul, D. L. (1998) · Circulation Research · doi:10.1161/01.res.83.6.636 · Cited by 272
Connexins: Key Mediators of Endocrine Function
Bosco, D., Haefliger, J.-A., & Meda, P. (2011) · Physiological Reviews · doi:10.1152/physrev.00027.2010 · Cited by 169
Metadata
- Venue
- Proceedings of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 1994-02-22
- Volume
- 255
- Issue
- 1343
- Pages
- 125-132
- ISSN
- 0080-4649 (ISSN-L)
- 0962-8452
- 1471-2954
- OpenAlex
- W1995748663
- Cited by
- 184
- References
- 0
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
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