The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Connexin43 Is Highly Localized to Sites of Disturbed Flow in Rat Aortic Endothelium but Connexin37 and Connexin40 Are More Uniformly Distributed
Abstract
Abstract —Vascular endothelial cells are linked by gap junctions, which facilitate the propagation of electrical and chemical signals along the vessel wall. The aim of this study was to determine the distribution and identity of the gap junction structural proteins (connexins) expressed by endothelial cells in situ. Connexin expression in different regions of the rat aortic endothelium was analyzed with the use of indirect immunofluorescence microscopy and Western blotting. Connexin40 and connexin37 were present in most, if not all, of the thoracic and abdominal aortic endothelia in the form of maculae at cell-cell appositions. In contrast, connexin43 was undetectable in most endothelia but extremely abundant in small numbers of cells localized at the downstream edge of the ostia of branching vessels and at flow dividers, regions that experience turbulent shear stress from disturbed blood flow. To examine the relationship of shear stress and connexin43 expression, localized stress was induced by surgical coarctation of the aorta, which was sufficient to cause striking local upregulation of connexin43 within 8 days. Thus, increases in connexin43 levels are an endothelial response to mechanical stress.
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Cites
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Self-citationHemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.
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Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.
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Hemodynamic forces are complex regulators of endothelial gene expression
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Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesisa
GIMBRONE, M. A., TOPPER, J. N., NAGEL, T., ANDERSON, K. R., & GARCIA‐CARDEÑA, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06318.x · Cited by 836
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586
Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
de Wit, C., Roos, F., Bolz, S.-S., Kirchhoff, S., Krüger, O., Willecke, K., & Pohl, U. (2000) · Circulation Research · doi:10.1161/01.res.86.6.649 · Cited by 338
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Metadata
- Authors
- Gabriels, J. E., & Paul, D. L.
- Venue
- Circulation Research
- Published
- 1998-09-21
- Volume
- 83
- Issue
- 6
- Pages
- 636-643
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W1991312277
- Cited by
- 272
- References
- 38
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Connexin43 Is Highly Localized to Sites of Disturbed Flow in Rat Aortic Endothelium but Connexin37 and Connexin40 Are More Uniformly Distributed. https://app.cochat.ai/papers/10.1161/01.res.83.6.636
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- Gabriels, J. E., & Paul, D. L. (1998). Connexin43 Is Highly Localized to Sites of Disturbed Flow in Rat Aortic Endothelium but Connexin37 and Connexin40 Are More Uniformly Distributed. Circulation Research. https://doi.org/10.1161/01.res.83.6.636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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