Applications of terahertz spectroscopy to pharmaceutical sciences
Abstract
The application of terahertz pulsed spectroscopy within the US Food and Drug Administration's (FDA's) recent process analytical technology (PAT) initiative is considered. As a case study the potency levels in paracetamol (4-acetamidophenol) and aspirin (acetylsalicylic acid) test tablets have been recovered from the terahertz absorption spectra using a multivariate partial-least-squares (PLS) calibration model. Root-mean-square errors of cross-validation (RMSECVs) of 2.85% and 3.90% were obtained for paracetamol and aspirin, respectively. Information about other excipients can also be obtained; for example, using the strong lactose absorption lines in the tablets, RMSECVs of 3.65% and 4.30% could be recovered from the paracetamol and aspirin samples, respectively. As active ingredients may also change their solid-state form during formulation processing or storage and as this can adversely affect the final dosage performance, monitoring of pharmaceutical ingredients is essential for a 'right-first-time' philosophy within the industry. Terahertz pulse spectroscopy is a high-throughput technique with many areas of potential exploitation in the pharmaceutical industry; these issues are discussed in this paper.
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The results obtained match data available in the literature [40], [41].
“Still, the results obtained match the data available in the literature [40], [41].”
From A New Metric for the Comparison of Permittivity Models in Terahertz Time-Domain Spectroscopy (2024) · cites this paper as [41]
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- Authors
- Taday, P. F.
- Affiliations
- TeraView (United Kingdom) (GB)
- Corresponding author
- Taday, Philip F.
- ORCID
- Taday, Philip F.
- Venue
- Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
- Publisher
- The Royal Society
- Published
- 2003-12-19
- Volume
- 362
- Issue
- 1815
- Pages
- 351-364
- ISSN
- 1364-503X (ISSN-L)
- 1471-2962
- OpenAlex
- W2167697843
- Cited by
- 239
- References
- 17
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 13
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences (publishedVersion)
- PubMed (publishedVersion)
- Science and Technology Facilities Council (submittedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Keywords
- terahertz spectroscopy, tablets, paracetamol, aspirin, process analytical technology, partial least squares calibration, terahertz absorption spectra, pharmaceutical quality control, high-throughput analysis
- MeSH terms
- Acetaminophen, Algorithms, Aspirin, Chemistry, Pharmaceutical, Drug Contamination, Infrared Rays, Microwaves, Quality Assurance, Health Care, Sensitivity and Specificity, Spectrophotometry, Infrared, Reproducibility of Results
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