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Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays

Murr, L. E., Gaytan, S. M., Medina, F., Lopez, H., Martinez, E., Machado, B. I., Hernandez, D. H., Martinez, L., Lopez, M. I., Wicker, R. B., Bracke, J.·2010·Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Abstract

In this paper, we examine prospects for the manufacture of patient-specific biomedical implants replacing hard tissues (bone), particularly knee and hip stems and large bone (femoral) intramedullary rods, using additive manufacturing (AM) by electron beam melting (EBM). Of particular interest is the fabrication of complex functional (biocompatible) mesh arrays. Mesh elements or unit cells can be divided into different regions in order to use different cell designs in different areas of the component to produce various or continually varying (functionally graded) mesh densities. Numerous design elements have been used to fabricate prototypes by AM using EBM of Ti-6Al-4V powders, where the densities have been compared with the elastic (Young) moduli determined by resonant frequency and damping analysis. Density optimization at the bone–implant interface can allow for bone ingrowth and cementless implant components. Computerized tomography (CT) scans of metal (aluminium alloy) foam have also allowed for the building of Ti-6Al-4V foams by embedding the digital-layered scans in computer-aided design or software models for EBM. Variations in mesh complexity and especially strut (or truss) dimensions alter the cooling and solidification rate, which alters the α -phase (hexagonal close-packed) microstructure by creating mixtures of α / α ′ (martensite) observed by optical and electron metallography. Microindentation hardness measurements are characteristic of these microstructures and microstructure mixtures ( α / α ′) and sizes.

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Metadata

Authors
Murr, L. E., Gaytan, S. M., Medina, F., Lopez, H., Martinez, E., Machado, B. I., Hernandez, D. H., Martinez, L., Lopez, M. I., Wicker, R. B., & Bracke, J.
Venue
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Published
2010-04-28
Volume
368
Issue
1917
Pages
1999-2032
ISSN
  • 1364-503X (ISSN-L)
  • 1471-2962
OpenAlex
W2036352099
Cited by
636
References
1
FWCI
23.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays. https://app.cochat.ai/papers/10.1098/rsta.2010.0010
The paper
Murr, L. E., Gaytan, S. M., Medina, F., Lopez, H., Martinez, E., Machado, B. I., Hernandez, D. H., Martinez, L., Lopez, M. I., Wicker, R. B., & Bracke, J. (2010). Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. https://doi.org/10.1098/rsta.2010.0010

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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