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Cited by 366

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Approximating the coalescent with recombination

Open access
McVean, Gilean A.T, Cardin, Niall J·2005·Philosophical Transactions of the Royal Society B: Biological Sciences
DOI 10.1098/rstb.2005.1673
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Abstract

The coalescent with recombination describes the distribution of genealogical histories and resulting patterns of genetic variation in samples of DNA sequences from natural populations. However, using the model as the basis for inference is currently severely restricted by the computational challenge of estimating the likelihood. We discuss why the coalescent with recombination is so challenging to work with and explore whether simpler models, under which inference is more tractable, may prove useful for genealogy-based inference. We introduce a simplification of the coalescent process in which coalescence between lineages with no overlapping ancestral material is banned. The resulting process has a simple Markovian structure when generating genealogies sequentially along a sequence, yet has very similar properties to the full model, both in terms of describing patterns of genetic variation and as the basis for statistical inference.

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Metadata

Authors
McVean, G. A. T., & Cardin, N. J.
Venue
Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher
The Royal Society
Published
2005-07-07
Volume
360
Issue
1459
Pages
1387-1393
ISSN
  • 0962-8436 (ISSN-L)
  • 1471-2970
DOI
10.1098/rstb.2005.1673
OpenAlex
W2147911093
Cited by
366
References
4
FWCI
1.51
Type
journal article
Language
en
Open access
green

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