The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Evolution of lactase persistence: an example of human niche construction
Open accessAbstract
Niche construction is the process by which organisms construct important components of their local environment in ways that introduce novel selection pressures. Lactase persistence is one of the clearest examples of niche construction in humans. Lactase is the enzyme responsible for the digestion of the milk sugar lactose and its production decreases after the weaning phase in most mammals, including most humans. Some humans, however, continue to produce lactase throughout adulthood, a trait known as lactase persistence. In European populations, a single mutation (−13910*T) explains the distribution of the phenotype, whereas several mutations are associated with it in Africa and the Middle East. Current estimates for the age of lactase persistence-associated alleles bracket those for the origins of animal domestication and the culturally transmitted practice of dairying. We report new data on the distribution of−13910*T and summarize genetic studies on the diversity of lactase persistence worldwide. We review relevant archaeological data and describe three simulation studies that have shed light on the evolution of this trait in Europe. These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models.
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Cites
Convergent adaptation of human lactase persistence in Africa and Europe
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Niche construction, biological evolution, and cultural change
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The Origins of Lactase Persistence in Europe
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Self-citationMutations arising in the wave front of an expanding population
Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308064100 · Cited by 429
Y genetic data support the Neolithic demic diffusion model
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Self-citationForaging and farming as niche construction: stable and unstable adaptations
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Cited by
Qin, Y., Havulinna, A. S., Liu, Y., Jousilahti, P., Ritchie, S. C., Tokolyi, A., Sanders, J. G., Valsta, L., Brożyńska, M., Zhu, Q., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00991-z · Cited by 586
Genetic architecture: the shape of the genetic contribution to human traits and disease
Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434
Niche Construction Theory: A Practical Guide for Ecologists
Odling-Smee, J., Erwin, D. H., Palkovacs, E. P., Feldman, M. W., & Laland, K. N. (2013) · The Quarterly Review of Biology · doi:10.1086/669266 · Cited by 466
Resilience in mental health: linking psychological and neurobiological perspectives.
Rutten, B. P. F., Hammels, C., Geschwind, N., Menne‐Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., & Wichers, M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12095 · Cited by 418
Detection of human adaptation during the past 2000 years
Field, Y., Boyle, E. A., Telis, N., Gao, Z., Gaulton, K. J., Golan, D., Yengo, L., Rocheleau, G., Froguel, P., McCarthy, M. I., et al. (2016) · Science · doi:10.1126/science.aag0776 · Cited by 383
Metadata
- Authors
- Gerbault, P., Liebert, A., Itan, Y., Powell, A., Currat, M., Burger, J., Swallow, D. M., & Thomas, M. G.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2011-03-27
- Volume
- 366
- Issue
- 1566
- Pages
- 863-877
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2163265523
- Cited by
- 509
- References
- 11
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- green
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