The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
Abstract
In this paper an analysis of 175 currently sequenced transport proteins that comprise the amino acid/polyamine/organocation (APC) superfamily is reported. Members of this superfamily fall into 10 well-defined families that are either prokaryote specific, eukaryote specific or ubiquitous. Most of these proteins exhibit 12 probable transmembrane spanners (TMSs), but members of two of these families deviate from this pattern, exhibiting 10 and 14 TMSs. All members of these families are tabulated, their functional properties are reviewed and phylogenetic/sequence analyses define the evolutionary relationships of the proteins to each other. Evidence is presented that the APC superfamily may include two other currently recognized families that exhibit greater degrees of sequence divergence from APC superfamily members than do the proteins of the 10 established families from each other. At least some of the protein members of these two distantly related families exhibit 11 established TMSs. Altogether, the APC superfamily probably includes 12 currently recognized families with members that exhibit exclusive specificity for amino acids and their derivatives but which can possess 10, 11, 12 or 14 TMSs per polypeptide chain.
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Cites
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Cited by
Wyant, G. A., Abu-Remaileh, M., Wolfson, R. L., Chen, W. W., Freinkman, E., Danai, L. V., Vander Heiden, M. G., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.09.046 · Cited by 470
Regulation of amino acid metabolic enzymes and transporters in plants
Pratelli, R., & Pilot, G. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru320 · Cited by 409
The Structural and Biochemical Foundations of Thiamin Biosynthesis
Jurgenson, C. T., Begley, T. P., & Ealick, S. E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.102340 · Cited by 355
Mechanisms of Acid Resistance in Escherichia coli
Kanjee, U., & Houry, W. A. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155708 · Cited by 339
Structure and Mechanism of a Na + -Independent Amino Acid Transporter
Shaffer, P. L., Goehring, A., Shankaranarayanan, A., & Gouaux, E. (2009) · Science · doi:10.1126/science.1176088 · Cited by 309
Metadata
- Authors
- Jack, D. L., Paulsen, I. T., & Saier, M. H.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2000-08-01
- Volume
- 146
- Issue
- 8
- Pages
- 1797-1814
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2135874673
- Cited by
- 285
- References
- 47
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jack, D. L., Paulsen, I. T., & Saier, M. H. (2000). The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiology. https://doi.org/10.1099/00221287-146-8-1797
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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