Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex

Synergy, antagonism, and what the chequerboard puts between them

Odds, F. C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg301 · Cited by 2,498 · see citing works

Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

Park, B. J., Wannemuehler, K. A., Marston, B. J., Govender, N. P., Pappas, P. G., & Chiller, T. M. (2009) · AIDS · doi:10.1097/qad.0b013e328322ffac · Cited by 2,013 · see citing works

A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing

Pierce, C. G., Uppuluri, P., Tristan, A. R., Wormley, F. L., Mowat, E., Ramage, G., & Lopez-Ribot, J. L. (2008) · Nature Protocols · doi:10.1038/nprot.2008.141 · Cited by 1,041 · see citing works

Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane

Devi, K. P., Nisha, S. A., Sakthivel, R., & Pandian, S. K. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.04.025 · Cited by 908 · see citing works

A COLORIMETRIC METHOD FOR THE DETERMINATION OF THE PROTEOLYTIC ACTIVITY OF DUODENAL JUICE

Charney, J., & Tomarelli, R. M. (1947) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41059-3 · Cited by 723 · see citing works

Extracellular Vesicles Produced by <i>Cryptococcus neoformans</i> Contain Protein Components Associated with Virulence

Rodrigues, M. L., Nakayasu, E. S., Oliveira, D. L., Nimrichter, L., Nosanchuk, J. D., Almeida, I. C., & Casadevall, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00370-07 · Cited by 558 · see citing works

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413 · see citing works

Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay

Breger, J. A., Fuchs, B. B., Aperis, G., Moy, T. I., Ausubel, F. M., & Mylonakis, E. E. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030018 · Cited by 334 · see citing works

Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis

Mylonakis, E. E., Ausubel, F. M., Perfect, J. R., Heitman, J., & Calderwood, S. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232568599 · Cited by 330 · see citing works

Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms

Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002257 · Cited by 291 · see citing works

Experimental modulation of capsule size in Cryptococcus neoformans

Zaragoza, Ó., & Casadevall, A. (2004) · Biological Procedures Online · doi:10.1251/bpo68 · Cited by 231 · see citing works

Susceptibility of Cryptococcus neoformans Biofilms to Antifungal Agents In Vitro

Martinez, L. R., & Casadevall, A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.3.1021-1033.2006 · Cited by 200 · see citing works

Transcriptional Network of Multiple Capsule and Melanin Genes Governed by theCryptococcus neoformansCyclic AMP Cascade

Pukkila-Worley, R., Gerrald, Q. D., Kraus, P. R., Boily, M.-J., Davis, M. J., Giles, S. S., Cox, G. M., Heitman, J., & Alspaugh, J. A. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.1.190-201.2005 · Cited by 181 · see citing works

Fungal heat-shock proteins in human disease

Burnie, J., Carter, T. L., Hodgetts, S. J., & Matthews, R. (2005) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2005.00001.x · Cited by 158 · see citing works

Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing

Shapiro, R. S., & Cowen, L. E. (2012) · mBio · doi:10.1128/mbio.00238-12 · Cited by 145 · see citing works

Heat Shock Protein 90 Is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus

Lamoth, F., Juvvadi, P. R., Fortwendel, J. R., & Steinbach, W. J. (2012) · Eukaryotic Cell · doi:10.1128/ec.00032-12 · Cited by 136 · see citing works

The Intracellular Life ofCryptococcus neoformans

Coelho, C., Bocca, A. L., & Casadevall, A. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104653 · Cited by 130 · see citing works

<i>Cryptococcus neoformans</i> Gene Expression during Experimental Cryptococcal Meningitis

Steen, B. R., Zuyderduyn, S., Toffaletti, D. L., Marra, M., Jones, S. J. M., Perfect, J. R., & Kronstad, J. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1336-1349.2003 · Cited by 123 · see citing works

Cryptococcus neoformans Capsular Polysaccharide and Exopolysaccharide Fractions Manifest Physical, Chemical, and Antigenic Differences

Frasés, S., Nimrichter, L., Viana, N. B., Nakouzi, A. S., & Casadevall, A. (2007) · Eukaryotic Cell · doi:10.1128/ec.00378-07 · Cited by 115 · see citing works

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

Shapiro, R. S., Zaas, A. K., Betancourt-Quiroz, M., Perfect, J. R., & Cowen, L. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044734 · Cited by 86 · see citing works

Evaluation of Mycograb®, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill methodologies

Nooney, L., Matthews, R., & Burnie, J. (2005) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2004.08.013 · Cited by 83 · see citing works

The highly immunogenic enolase and Hsp70p are adventitious Candida albicans cell wall proteins

Eroles, P., Sentandreu, M., Elorza, M. V., & Sentandreu, R. (1997) · Microbiology · doi:10.1099/00221287-143-2-313 · Cited by 83 · see citing works

Urban Pigeons (Columba livia) as a Potential Source of Pathogenic Yeasts: A Focus on Antifungal Susceptibility of Cryptococcus Strains in Northeast Brazil

Costa, A. K. F., Sidrim, J. J. C., Cordeiro, R. D. A., Brilhante, R. S. N., Monteiro, A. J., & Rocha, M. F. G. (2009) · Mycopathologia · doi:10.1007/s11046-009-9245-1 · Cited by 80 · see citing works

Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis

Kakeya, H., Udono, H., Maesaki, S., Sasaki, E., Kawamura, S., HOSSAIN, M. A., Yamamoto, Y., Sawai, T., Fukuda, M., Mitsutake, K., et al. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00821.x · Cited by 56 · see citing works

The heat shock protein (Hsp) 70 of Cryptococcus neoformans is associated with the fungal cell surface and influences the interaction between yeast and host cells

Silveira, C. P., Piffer, A. C., Kmetzsch, L., Fonseca, F. L., Soares, D. A., Staats, C. C., Rodrigues, M. L., Schrank, A., & Vainstein, M. H. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.08.005 · Cited by 56 · see citing works

A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary cryptococcosis

Kakeya, H., Udono, H., Ikuno, N., Yamamoto, Y., Mitsutake, K., Miyazaki, T., Tomono, K., Koga, H., Tashiro, T., Nakayama, E., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.5.1653-1658.1997 · Cited by 54 · see citing works

Molecular Identification of Cryptococcus neoformans Serotypes

Angoulvant, A., Chandenier, J., Symoens, F., Lacube, P., BOLOGNINI, J., Douchet, C., POIROT, J. L., & Hennequin, C. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01839-06 · Cited by 49 · see citing works

Coupling temperature sensing and development

Shapiro, R. S., & Cowen, L. E. (2010) · Virulence · doi:10.4161/viru.1.1.10320 · Cited by 49 · see citing works

Fluconazole Alters the Polysaccharide Capsule of Cryptococcus gattii and Leads to Distinct Behaviors in Murine Cryptococcosis

dos Santos, J. R. A., Holanda, R. A., Frasés, S., Bravim, M., Araújo, G. R. D. S., Santos, P. C., da Costa, M. C., Ribeiro, M. J. A., Ferreira, G. F., Baltazar, L. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112669 · Cited by 46 · see citing works

The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability

Nicola, A. M., de Andrade, R. V., Dantas, A. D. S., Andrade, P. A., Arraes, F. B. M., Fernandes, L., Silva-Pereira, I., & Felipe, M. S. S. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-158 · Cited by 43 · see citing works

Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of<i>Candida</i>and<i>Aspergillus</i>species

Chen, S. C.-A., Lewis, R. E., & Kontoyiannis, D. P. (2011) · Virulence · doi:10.4161/viru.2.4.16764 · Cited by 41 · see citing works

Involvement of the 90kDa heat shock protein during adaptation of Paracoccidioides brasiliensis to different environmental conditions

Tamayo, D. P., Muñoz, J. F., Torres, I. P., Almeida, A. J., Restrepo, Á., McEwen, J. G., & Hernández, O. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.11.005 · Cited by 39 · see citing works

Antifolates inhibit Cryptococcus biofilms and enhance susceptibility of planktonic cells to amphotericin B

Cordeiro, R. D. A., Mourão, C. I., Rocha, M. F. G., Marques, F. J. D. F., Teixeira, C. E. C., Miranda, D. F. D. O., Neto, L. V. P., Brilhante, R. S. N., Bandeira, T. D. J. P. G., & Sidrim, J. J. C. (2012) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-012-1774-8 · Cited by 20 · see citing works

Influence of capsule size on the in vitro activity of antifungal agents against clinical Cryptococcus neoformans var. grubii strains

Vitale, R. G., Pascuccelli, V., & Afeltra, J. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.036152-0 · Cited by 19 · see citing works

Melanin production at 37°C is linked to the high virulent Cryptococcus gattii Vancouver Island outbreak genotype VGIIa.

Ngamskulrungroj, P., & Meyer, W. (2009) · Cited by 17 · see citing works

Antifungal activity of radicicol against Mucor flavus IFO 9560

Fujita, K., Irie, M., Ping, X., & Taniguchi, M. (1999) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(99)80214-x · Cited by 17 · see citing works

Medical Mycology – Cellular and Molecular Techniques

Aepinus, C. (2008) · Journal of Laboratory Medicine · doi:10.1515/jlm.2008.012 · Cited by 16 · see citing works

Development of a Selective Medium for the Fungal Pathogen Cylindrocarpon destructans Using Radicicol

Kang, Y., Lee, S., & Lee, J. (2014) · The Plant Pathology Journal · doi:10.5423/ppj.nt.08.2014.0073 · Cited by 15 · see citing works

Temporal Behavior of Capsule Enlargement by Cryptococcus neoformans

Cordero, R. J. B., Bergman, A., & Casadevall, A. (2013) · Eukaryotic Cell · doi:10.1128/ec.00163-13 · Cited by 15 · see citing works

Cryptococcus gattii Infections and Virulence

Harris, J. R., Galanis, E., & Lockhart, S. R. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-013-0170-x · Cited by 7 · see citing works

In Vitro Growth Characteristics of Two Cryptococcus neoformans Isolates

Jones, K. L., & Murphy, J. W. (1998) · Journal of the Arkansas Academy of Science · Cited by 1 · see citing works

Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works

Treatment strategies for cryptococcal infection: challenges, advances and future outlook

Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00511-0 · Cited by 363 · see citing works

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

Carolus, H., Pierson, S., Lagrou, K., & Dijck, P. V. (2020) · Journal of Fungi · doi:10.3390/jof6040321 · Cited by 364 · see citing works

Molecular mechanisms governing antifungal drug resistance

Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance · doi:10.1038/s44259-023-00007-2 · Cited by 304 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0002-2016 · Cited by 271 · see citing works

Combinatorial strategies for combating invasive fungal infections

Spitzer, M., Robbins, N., & Wright, G. D. (2016) · Virulence · doi:10.1080/21505594.2016.1196300 · Cited by 218 · see citing works

Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Monk, B. C., Sagatova, A. A., Hosseini, P., Ruma, Y. N., Wilson, R. K., & Keniya, M. V. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.02.008 · Cited by 136 · see citing works

Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

Dijck, P. V., Sjollema, J., Cammue, B. P. A., Lagrou, K., Berman, J. G., d’Enfert, C., Andes, D. R., Arendrup, M. C., Brakhage, A. A., Calderone, R., et al. (2018) · Microbial Cell · doi:10.15698/mic2018.07.638 · Cited by 129 · see citing works

Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

Gong, Y., Li, T., Yu, C., & Sun, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00520 · Cited by 101 · see citing works

Characterization of Aspergillus fumigatus Extracellular Vesicles and Their Effects on Macrophages and Neutrophils Functions

Souza, J. A. M., Baltazar, L. D. M., Carregal, V. M., Gouveia‐Eufrásio, L., de Oliveira, A. G., Dias, W. G., Rocha, M. C., de Miranda, K. R., Malavazi, I., Santos, D. A., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02008 · Cited by 89 · see citing works

Bioactive Peptides Against Fungal Biofilms

Oshiro, K. G. N., Rodrigues, G. R., Monges, B. E. D., Cardoso, M. H. E. S., & Franco, O. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02169 · Cited by 83 · see citing works

Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going?

Ngan, N. T. T., Flower, B., & Day, J. (2022) · Drugs · doi:10.1007/s40265-022-01757-5 · Cited by 80 · see citing works

New Approaches for Cryptococcosis Treatment

Spadari, C. D. C., Wirth, F., Lopes, L. B., & Ishida, K. (2020) · Microorganisms · doi:10.3390/microorganisms8040613 · Cited by 73 · see citing works

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

Huang, D. S., LeBlanc, E. V., Shekhar‐Guturja, T., Robbins, N., Krysan, D. J., Pizarro, J. C., Whitesell, L. J., Cowen, L. E., & Brown, L. E. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00826 · Cited by 63 · see citing works

Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans

Chatterjee, S., & Tatu, U. (2017) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0005836 · Cited by 57 · see citing works

Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

Marcyk, P. T., LeBlanc, E. V., Kuntz, D. A., Xue, A., Ortiz, F., Trilles, R., Bengtson, S., Kenney, T. M. G., Huang, D. S., Robbins, N., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01777 · Cited by 40 · see citing works

Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi

Roy, A., & Tamuli, R. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-02833-w · Cited by 36 · see citing works

Resistance to antifungal therapies

Prasad, R., Banerjee, A., & Shah, A. H. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160067 · Cited by 33 · see citing works

New antifungal strategies and drug development against WHO critical priority fungal pathogens

Li, Y., Liu, Y., Jiang, Y., Yang, Y., Ni, W., Zhang, W., & Tan, L. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1662442 · Cited by 36 · see citing works

Chaperone Networks in Fungal Pathogens of Humans

Horianopoulos, L. C., & Kronstad, J. W. (2021) · Journal of Fungi · doi:10.3390/jof7030209 · Cited by 29 · see citing works

Genetic analysis of Hsp90 function in <i>Cryptococcus neoformans</i> highlights key roles in stress tolerance and virulence

Fu, C., Beattie, S. R., Jezewski, A. J., Robbins, N., Whitesell, L., Krysan, D. J., & Cowen, L. E. (2022) · Genetics · doi:10.1093/genetics/iyab164 · Cited by 31 · see citing works

Structure-guided approaches to targeting stress responses in human fungal pathogens

LeBlanc, E. V., Polvi, E. J., Veri, A. O., Privé, G. G., & Cowen, L. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.013731 · Cited by 31 · see citing works

The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans

Horianopoulos, L. C., Hu, G., Caza, M., Schmitt, K., Overby, P., Johnson, J. D., Valerius, O., Braus, G. H., & Kronstad, J. W. (2020) · mBio · doi:10.1128/mbio.01127-20 · Cited by 30 · see citing works

Environmental microbiome, human fungal pathogens, and antimicrobial resistance

Yan, Z., Hu, H., Xiong, C., Peleg, A. Y., Chen, Q., Sáez‐Sandino, T., Maestre, F. T., Delgado‐Baquerizo, M., & Singh, B. K. (2024) · Trends in Microbiology · doi:10.1016/j.tim.2024.08.003 · Cited by 28 · see citing works

Insights and Perspectives on the Role of Proteostasis and Heat Shock Proteins in Fungal Infections

Neves‐da‐Rocha, J., Santos-Saboya, M. J., Lopes, M. E. R., Rossi, A., & Martinez-Rossi, N. M. (2023) · Microorganisms · doi:10.3390/microorganisms11081878 · Cited by 27 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch44 · Cited by 26 · see citing works

Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis

Maliehe, M., Ntoi, M. A., Lahiri, S., Folorunso, O. S., Ogundeji, A. O., Pohl, C. H., & Sebolai, O. M. (2020) · Microorganisms · doi:10.3390/microorganisms8020180 · Cited by 27 · see citing works

Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress

Horianopoulos, L. C., Lee, C. W. J., Hu, G., Caza, M., & Kronstad, J. W. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.727039 · Cited by 22 · see citing works

Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans

Ishii, M., Matsumoto, Y., & Sekimizu, K. (2016) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2016.01015 · Cited by 23 · see citing works

Pre-Exposure With Extracellular Vesicles From Aspergillus fumigatus Attenuates Inflammatory Response and Enhances Fungal Clearance in a Murine Model Pulmonary Aspergillosis

Souza, J. A. M., Gurgel, I. L. D. S., Malacco, N. L. S. D. O., Martins, F. R. B., Queiroz‐Junior, C. M., Teixeira, M. M., & Soriani, F. M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.898619 · Cited by 22 · see citing works

Antifungal activity of promethazine and chlorpromazine against planktonic cells and biofilms of Cryptococcus neoformans/Cryptococcus gattii complex species

Brilhante, R. S. N., Gotay, W. J. P., Pereira, V. S., de Oliveira, J. S., Pereira‐Neto, W. D. A., Castelo‐Branco, D. D. S. C. M., Cordeiro, R. D. A., Sidrim, J. J. C., & Rocha, M. F. G. (2020) · Medical Mycology · doi:10.1093/mmy/myz140 · Cited by 21 · see citing works

Virulence Factors as Targets for Anticryptococcal Therapy

Azevedo, R. V. D. M., Rizzo, J., & Rodrigues, M. L. (2016) · Journal of Fungi · doi:10.3390/jof2040029 · Cited by 20 · see citing works

Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay

Xu, L., Li, Y., Biggins, J. B., Bowman, B. R., Verdine, G. L., Gloer, J. B., Alspaugh, J. A., & Bills, G. F. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-8792-0 · Cited by 19 · see citing works

β-lactam Antibiotics & Vancomycin Increase the Growth & Virulence of Candida spp.

Cordeiro, R. D. A., Evangelista, A. J. D. J., Serpa, R., de Andrade, A. R. C., Mendes, P. B. L., Franco, J. D. S., de Oliveira, J. S., de Alencar, L. P., Sales, J. A., Câmara, L. M. C., et al. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0019 · Cited by 18 · see citing works

Hsp90 interaction networks in fungi—tools and techniques

Crunden, J. L., & Diezmann, S. (2021) · FEMS Yeast Research · doi:10.1093/femsyr/foab054 · Cited by 15 · see citing works

Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicans

Alaalm, L., Crunden, J. L., Butcher, M. C., Obst, U., Whealy, R. N., Williamson, C. E., O’Brien, H., Schaffitzel, C., Ramage, G., SPENCER, J. M., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.637836 · Cited by 16 · see citing works

Drug design strategies for the treatment azole-resistant candidiasis

Moghimi, S., Shafiei, M., & Foroumadi, A. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2022.2098949 · Cited by 13 · see citing works

Antifungal discovery

Robbins, N., & Cowen, L. E. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102198 · Cited by 15 · see citing works

Proteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, to influence fungal virulence determinants in cryptococcosis

Ball, B., Sukumaran, A., Pladwig, S., Kazi, S., Chan, N., Honeywell, E., Modrakova, M., & Geddes‐McAlister, J. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00152-24 · Cited by 14 · see citing works

Stress Responses and Mechanisms of Phytopathogens Infecting Humans: Threats, Drivers, and Recommendations

Hossain, M. M., Sultana, F., Mostafa, M., Ferdus, H., Kundu, M., Adhikary, S., Akter, N., Saha, A., & Sabbir, M. A. A. (2025) · Stresses · doi:10.3390/stresses5020028 · Cited by 13 · see citing works

Combating increased antifungal drug resistance in Cryptococcus, what should we do in the future?

Deng, H., Song, J., Huang, Y., Yang, C., Zang, X., Zhou, Y., Li, H., Dai, B., & Xue, X. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023011 · Cited by 11 · see citing works

Synergistic effects of geldanamycin with fluconazole are associated with reactive oxygen species in Candida tropicalis resistant to azoles and amphotericin B

Jia, C., Zhang, J., Zhuge, Y., Xu, K., Liu, J., Wang, J., Li, L., & Chu, M. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1610563 · Cited by 11 · see citing works

A Silkworm Infection Model to Evaluate Antifungal Drugs for Cryptococcosis

Matsumoto, Y., Ishii, M., Shimizu, K., Kawamoto, S., & Sekimizu, K. (2017) · Medical Mycology Journal · doi:10.3314/mmj.17.016 · Cited by 9 · see citing works

Gene, virulence and related regulatory mechanisms in Cryptococcus gattii

Huang, Y., Zang, X., Yang, C., Deng, H., Ma, X., Xie, M., Zhou, M., Song, J., & Xue, X. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022029 · Cited by 8 · see citing works

Darunavir inhibits Cryptococcus neoformans/Cryptococcus gattii species complex growth and increases the susceptibility of biofilms to antifungal drugs

Brilhante, R. S. N., Silva, J. A. T., Araújo, G. D. S., Pereira, V. S., Gotay, W. J. P., de Oliveira, J. S., Guedes, G. M. D. M., Pereira‐Neto, W. D. A., Castelo‐Branco, D. D. S. C. M., Cordeiro, R. D. A., et al. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001194 · Cited by 8 · see citing works

The small heat shock protein Hsp12.1 has a major role in the stress response and virulence of Cryptococcus gattii

Motta, H., Reuwsaat, J. C. V., Squizani, E. D., Camargo, M. D. S., Garcia, A. W. A., Schrank, A., Vainstein, M. H., Staats, C. C., & Kmetzsch, L. (2023) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2023.103780 · Cited by 7 · see citing works

Fungal heat shock proteins: molecular phylogenetic insights into the host takeover

Sagini, J. P. N., & Ligabue‐Braun, R. (2024) · Die Naturwissenschaften · doi:10.1007/s00114-024-01903-x · Cited by 7 · see citing works

Antifungal therapy for the treatment of CNS infections

Aboabdo, M., & Mishkin, A. D. (2024) · Current Fungal Infection Reports · doi:10.1007/s12281-024-00492-6 · Cited by 7 · see citing works

Current and emerging therapies for fungal biofilms and systemic infections

Elgammal, Y., Martinez, R. I. G., Requejo, A., & Martinez, L. R. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2570185 · Cited by 4 · see citing works

Heat Shock Proteins in Medically Relevant Fungal Pathogens: From Molecular Chaperones to Virulence Factors and Therapeutic Targets

Padró-Villegas, L., & Mora-Montes, H. M. (2026) · Journal of Fungi · doi:10.3390/jof12060414 · Cited by 3 · see citing works

Pomegranate sarcotesta lectin (PgTeL) inhibits planktonic growth and disrupts biofilm formed by Cryptococcus neoformans

Ferreira, G. R. S., da Silva, P. M., Lopes, W., Feitosa, A. P. S., Coelho, L. C. B. B., Brayner, F. A., Alves, L. C., Paiva, P. M. G., de Moura, M. C., Vainstein, M. H., et al. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad150 · Cited by 3 · see citing works

Exploring Small Heat Shock Proteins (sHSPs) for Targeting Drug Resistance in Candida albicans and other Pathogenic Fungi

Dev, R. (2021) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.15.1.42 · Cited by 3 · see citing works

Induction Treatment for HIV-Associated Cryptococcal Meningitis: Where Have We Been and Where Are We Going?

Milsap, D., Okuno, M., Kigozi, E., Mugabi, T., Ssekindi, F., Bajer, A., Gakuru, J., & Bahr, N. C. (2025) · Microorganisms · doi:10.3390/microorganisms13040847 · Cited by 4 · see citing works

HSP90 inhibitors beyond oncology: optimization and mechanism insights in non-oncological diseases

Yin, X., Shu, H., Wang, D., You, Q., Zhang, Q., & Wang, L. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104514 · Cited by 2 · see citing works

The Regulatory Function of the Molecular Chaperone Hsp90 in the Cell Wall Integrity of Pathogenic Fungi

Rocha, M. C., Santos, C. A., & Malavazi, I. (2018) · Current Proteomics · doi:10.2174/1570164615666180820155807 · Cited by 2 · see citing works

A novel Hsp90 phospho-switch modulates virulence in the major human fungal pathogen Candida albicansPreprint

Alaalm, L., Crunden, J. L., Butcher, M. C., Obst, U., Whealy, R. N., Williamson, C. E., O’Brien, H., Schaffitzel, C., Ramage, G., & Diezmann, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.23.309831 · Cited by 2 · see citing works

Antifungal Activity, Antibiofilm and Association Studies withO‐Alkylamidoximes againstCryptococcusspp.

Teixeira, A. P. D. C., Moraes, G. F. Q., de Oliveira, R. J., Santos, C. S., Caiana, R. R. A., Freitas, J. C. R., Vasconcelos, U., Pereira, F. D. O., & Lima, I. O. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200539 · Cited by 1 · see citing works

In the Crossroad Between Drug Resistance and Virulence in Fungal Pathogens

Cavalheiro, M., & Teixeira, M. C. (2018) · Springer eBooks · doi:10.1007/978-3-030-00683-9_7 · Cited by 1 · see citing works

Regulation of Hsp80 involved in the acquisition of induced thermotolerance, and NCA-2 involved in calcium stress tolerance by the calcineurin-CRZ-1 signaling pathway in Neurospora crassa

Roy, A., & Tamuli, R. (2022) · Mycological Progress · doi:10.1007/s11557-022-01833-w · Cited by 1 · see citing works

The CRZ-1 Transcription Factor Regulates Hsp 80 Involves in the Acquisition of Thermotolerance, and NCA-2 for Calcium Stress Tolerance in Neurospora CrassaPreprint

Roy, A., & Tamuli, R. (2021) · Research Square · doi:10.21203/rs.3.rs-548634/v1 · Cited by 1 · see citing works

Genomic Polymorphism of Trichophyton Rubrum Isolated from Keratinized Clinical Sources using the RAPD-PCR Method

Amini, K., Chehreii, S., & malekabadi, P. (2021) · journal of ilam university of medical sciences · doi:10.52547/sjimu.29.1.5

Integration of homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, drives fungal virulence in cryptococcosisPreprint

Ball, B., Sukumaran, A., Pladwig, S., Kazi, S., Chan, N., Modrakova, M., & Geddes‐McAlister, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.03.535320

Mammalian-evolved strains of the fungal pathogen Cryptococcus neoformans show adaptation via heritable transcript level differences specific to mouse MHC haplotype

Ayers, C. B., Nalley, M. J., Madhani, H. D., Potts, W. K., McClelland, E. E., & Seipelt-Thiemann, R. L. (2026) · BMC Genomics · doi:10.1186/s12864-026-13196-7

Inhibition of Hsp90 regulates fluconazole resistance in the pathogenic fungus Cryptococcus neoformans

Darrah, B., Shah, D. P., & Chandrasekaran, S. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.l8112

Efeito do bloqueio das proteínas hsp90 sobre a sensibilidade a antifúngicos e produção de fatores de virulência no complexo cryptococcus neoformans/C. Gattii

Evangelista, A. J. D. J. (2015) · Americanae (AECID Library)

Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans

Chatterjee, S., & Tatu, U. (2017) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0005836 · Cited by 57 · see citing works

Heat Shock Protein 90 (Hsp90) in Fungal Growth and Pathogenesis

Lamoth, F., Juvvadi, P. R., & Steinbach, W. J. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-014-0195-9 · Cited by 10 · see citing works

Genetic analysis of Hsp90 function in <i>Cryptococcus neoformans</i> highlights key roles in stress tolerance and virulence

Fu, C., Beattie, S. R., Jezewski, A. J., Robbins, N., Whitesell, L., Krysan, D. J., & Cowen, L. E. (2022) · Genetics · doi:10.1093/genetics/iyab164 · Cited by 31 · see citing works