The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Transcriptome and proteome analysis of Bacillus subtilis gene expression in response to superoxide and peroxide stress
Abstract
The Gram-positive soil bacterium Bacillus subtilis responds to oxidative stress by the activation of different cellular defence mechanisms. These are composed of scavenging enzymes as well as protection and repair systems organized in highly sophisticated networks. In this study, the peroxide and the superoxide stress stimulons of B. subtilis were characterized by means of transcriptomics and proteomics. The results demonstrate that oxidative-stress-responsive genes can be classified into two groups. One group encompasses genes which show similar expression patterns in the presence of both reactive oxygen species. Examples are members of the PerR and the Fur regulon which were induced by peroxide and superoxide stress. Similarly, both kinds of stress stimulated the activation of the stringent response. The second group is composed of genes primarily responding to one stimulus, like the members of the SOS regulon which were particularly upregulated in the presence of peroxide, and many genes involved in sulfate assimilation and methionine biosynthesis which were only induced by superoxide. Several genes encoding proteins of unknown function could be assigned to one of these groups.
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Cites
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
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Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters
Fridovich, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18515 · Cited by 1,337
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Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions
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Cited by
Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., Bidnenko, E., Marchadier, E., Hoebeke, M., Aymerich, S., et al. (2012) · Science · doi:10.1126/science.1206848 · Cited by 910
Self-citationHow to select a probiotic? A review and update of methods and criteria
de Melo Pereira, G. V., de Oliveira Coelho, B., Magalhães Júnior, A. I., Thomaz-Soccol, V., & Soccol, C. R. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.09.003 · Cited by 523
Functional specialization within the Fur family of metalloregulators
Lee, J.-W., & Helmann, J. D. (2007) · BioMetals · doi:10.1007/s10534-006-9070-7 · Cited by 432
A comprehensive proteome map of growing Bacillus subtilis cells
Eymann, C., Dreisbach, A., Albrecht, D., Bernhardt, J., Becher, D., Gentner, S., Tam, L. T., Büttner, K., Buurman, G., Scharf, C., et al. (2004) · PROTEOMICS · doi:10.1002/pmic.200400907 · Cited by 286
Self-citationStaphylococcal response to oxidative stress
Gaupp, R., Ledala, N., & Somerville, G. A. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00033 · Cited by 253
Metadata
- Authors
- Mostertz, J., Scharf, C., Hecker, M., & Homuth, G.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2004-02-01
- Volume
- 150
- Issue
- 2
- Pages
- 497-512
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2096859475
- Cited by
- 241
- References
- 7
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mostertz, J., Scharf, C., Hecker, M., & Homuth, G. (2004). Transcriptome and proteome analysis of Bacillus subtilis gene expression in response to superoxide and peroxide stress. Microbiology. https://doi.org/10.1099/mic.0.26665-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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