The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of human immunodeficiency virus 1 transcription by nef microRNA
Abstract
MicroRNAs (miRNAs) are ∼21–25 nt long and interact with mRNAs to lead to either translational repression or RNA cleavage through RNA interference. A previous study showed that human immunodeficiency virus 1 (HIV-1) nef dsRNA from AIDS patients who are long-term non-progressors inhibited HIV-1 transcription. In the study reported here, nef-derived miRNAs in HIV-1-infected and nef transduced cells were identified, and showed that HIV-1 transcription was suppressed by nef-expressing miRNA, miR-N367, in human T cells. The miR-N367 could reduce HIV-1 LTR promoter activity through the negative responsive element of the U3 region in the 5′-LTR. Therefore, nef miRNA produced in HIV-1-infected cells may downregulate HIV-1 transcription through both a post-transcriptional pathway and a transcriptional neo-pathway.
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Cites
Feline foamy virus Tas protein is a DNA-binding transactivator
Omoto, S., Brisibe, E. A., Okuyama, H., & Fujii, Y. R. (2004) · Journal of General Virology · doi:10.1099/vir.0.80088-0 · Cited by 9
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Cited by
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
Carosella, E. D., Rouas-Freiss, N., Roux, D. T.-L., Moreau, P., & LeMaoult, J. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395
Ahluwalia, J. K., Khan, S. Z., Soni, K., Rawat, P., Gupta, A., Hariharan, M., Scaria, V., Lalwani, M., Pillai, B., Mitra, D., et al. (2008) · Retrovirology · doi:10.1186/1742-4690-5-117 · Cited by 279
Sullivan, C. S., & Ganem, D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.012 · Cited by 262
Yeung, M. L., Bennasser, Y., Watashi, K., Le, S.-Y., Houzet, L., & Jeang, K.-T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp707 · Cited by 244
Metadata
- Authors
- Omoto, S., & Fujii, Y. R.
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2005-03-01
- Volume
- 86
- Issue
- 3
- Pages
- 751-755
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- OpenAlex
- W2120992799
- Cited by
- 170
- References
- 1
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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