The Role of Toll-Like Receptors in Osteoclastogenesis
Open accessAbstract
Bone homeostasis is maintained by a balance in the levels of osteoclast and osteoblast activity. Osteoclasts are bone-resorbing cells and have been shown to act as key players in various osteolytic diseases. Osteoclasts differentiate from monocyte/macrophage lineage cells in the presence of receptor activator of nuclear factor-κB ligand and macrophage colony-stimulating factor. Osteoblasts support osteoclastogenesis by producing several osteoclast differentiation factors. Toll-like receptors (TLRs) are members of the pattern recognition receptor family that are involved in recognizing pathogen-associated molecular patterns and damage-associated molecular patterns in response to pathogen infection. TLRs regulate osteoclastogenesis and bone resorption through either the myeloid differentiation primary response 88 or the Toll/interleukin-1 receptor domaincontaining adapter-inducing interferon-β signaling pathways. Since osteoclasts play a central role in the progression of osteolytic diseases, extensive research focusing on TLR downstream signaling in these cells should be conducted to advance the development of effective TLR modulators. In this review, we summarize the currently available information on the role of TLRs in osteoclast differentiation and osteolytic diseases.
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TLRs expressed on osteoclast progenitors promote differentiation toward the mature cell phenotype, as observed in inflammatory osteolytic diseases.
“Additionally, Toll-like receptors (TLRs) expressed on osteoclast progenitors178 promote differentiation toward the mature cell phenotype, as observed in inflammatory osteolytic diseases.179”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [179]
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Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
- Authors
- Yim, M.
- Affiliations
- Sookmyung Women's University (KR)
- Corresponding author
- Yim, Mijung
- ORCID
- Yim, Mijung
- Venue
- Journal of Bone Metabolism
- Published
- 2020-11-30
- Volume
- 27
- Issue
- 4
- Pages
- 227-235
- ISSN
- 2287-6375 (ISSN-L)
- 2287-7029
- PMC
- PMC7746484
- OpenAlex
- W3111548010
- Cited by
- 28
- References
- 85
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Bone Metabolism (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Korean Society for Bone and Mineral Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- Toll-like receptors, osteoclastogenesis, bone resorption, bone homeostasis, osteolytic diseases, MyD88 signaling, TRIF signaling, RANKL, macrophage colony-stimulating factor, osteoblasts, pattern recognition receptors
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