The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2
Open accessPreprint — published as 10.1164/rccm.202001-0179le · Paper page
Abstract
Abstract A novel coronavirus SARS-CoV-2 was identified in Wuhan, Hubei Province, China in December of 2019. According to WHO report, this new coronavirus has resulted in 76,392 confirmed infections and 2,348 deaths in China by 22 February, 2020, with additional patients being identified in a rapidly growing number internationally. SARS-CoV-2 was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral entry, reproduction and transmission. This study provides a biological background for the epidemic investigation of the COVID-19, and could be informative for future anti-ACE2 therapeutic strategy development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“SARS-CoV-2 mainly infect alveolar epithelial type II (AE2) cells (Zhao et al., 2020)”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Zhao et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Self-citationClinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, K. S. M., Lau, E. H. Y., Wong, J. Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001316 · Cited by 16,575
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., & van Goor, H. (2004) · The Journal of Pathology · doi:10.1002/path.1570 · Cited by 5,676
Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., & Hao, P. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1637-5 · Cited by 2,202
Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C.-I., Ren, Z., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201712-2410oc · Cited by 1,203
Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes
Yang, J., Lin, S.-S., Ji, X.-J., & Guo, L.-M. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0109-4 · Cited by 1,117
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion ConformationPreprint
Wrapp, D., Wang, N., Corbett, K. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.11.944462 · Cited by 1,010
Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2951-z · Cited by 715
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- 2020, Novel Wuhan (2019-nCoV) Coronavirus, American Journal of Respiratory and Critical Care Medicine, 201, P7
- Zhao Y , Zhao ZX , Wang YJ , Zhou YQ , Ma Y , Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv 2020.01.26.919985.
Cited by
Sorted by citations
Items 301–400 of 850
Ding, T., Zhang, J., Wang, T., Cui, P., Chen, Z., Jiang, J., Zhou, S., Dai, J., Wang, B., Yuan, S., et al. (2020) · medRxiv · doi:10.1101/2020.03.26.20043943 · Cited by 41
COVID-19, chronic inflammatory rheumatic disease and anti-rheumatic treatments
Ouedraogo, D., Tiendrébeogo, W. J. S. Z., Kaboré, F., & Ntsiba, H. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05189-y · Cited by 40
Juan, J., Gil, M. M., Rong, Z., Zhang, Y., Yang, H., & Poon, L. C. (2020) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.23059 · Cited by 40
Farnoosh, G., Ghanei, M., Khorramdelazad, H., Alishiri, G. H., Farahani, A. J., Shahriary, A., & Zijoud, S. R. H. (2020) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2020.156 · Cited by 42
An update on ACE2 amplification and its therapeutic potential
Márquez, A., Wysocki, J. A., Pandit, J. A., & BATLLE, D. C. (2020) · Acta Physiologica · doi:10.1111/apha.13513 · Cited by 40
ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID‐19
Rezaei, M. S., Ziai, S. A., Fakhri, S., & Pouriran, R. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30041 · Cited by 40
Moghadam, M. T., Taati, B., Ardakani, S. M. P., & Suzuki, K. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.570235 · Cited by 41
Atlas of ACE2 gene expression in mammals reveals novel insights in transmisson of SARS-Cov-2Preprint
Sun, K., Gu, L., Ma, L., & Duan, Y. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.015644 · Cited by 38
Stanifer, M. L., Kee, C., Cortese, M., Triana, S., Mukenhirn, M., Kraeusslich, H.-G., Alexandrov, T., Bartenschlager, R. F. W., & Boulant, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.24.059667 · Cited by 40
Neurological manifestations of COVID-19: a review of what we know so far
Gklinos, P. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09939-5 · Cited by 40
Oberemok, V. V., Laikova, K. V., Yurchenko, K. A., Фомочкина, И. И., & Kubyshkin, A. V. (2020) · Inflammation Research · doi:10.1007/s00011-020-01352-y · Cited by 39
COVID-19 and Heart: From Clinical Features to Pharmacological Implications
Russo, V., Bottino, R., Carbone, A., Rago, A., Papa, A. A., Golino, P., & Nigro, G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061944 · Cited by 39
Vocal Disorders in Patients with COVID 19 in Egypt
Azzam, A. A. A., Samy, A., Sefein, I. K., & Elrouby, I. M. (2021) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-021-02663-0 · Cited by 39
Structure of dimeric full-length human ACE2 in complex with B 0 AT1Preprint
Yan, R., Zhang, Y., Li, Y., Xia, L., & Zhou, Q. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.17.951848 · Cited by 39
Chen, Y., Shan, K.-J., & Qian, W. (2020) · Preprints.org · doi:10.20944/preprints202002.0258.v2 · Cited by 39
Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies
Abubakar, M. B., Usman, D., Batiha, G. E., Martins, N. A., Malami, I., Ibrahim, K. G., Abubakar, B., Bello, M. B., Muhammad, A. I., Gan, S. H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629935 · Cited by 38
Zheng, X., Chen, J., Deng, L., Fang, Z., Chen, G., Ye, D., Xia, J., & Hong, Z. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26367 · Cited by 36
A Correlation Analysis Between the Nutritional Status and Prognosis of COVID-19 Patients
Zhou, J., Ma, Y., Liu, Y., Xiang, Y., Tao, C. Z., Yu, H., & Huang, J. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1457-6 · Cited by 40
Self-citationProspective role of thyroid disorders in monitoring COVID-19 pandemic
Kumari, K., Chainy, G. B. N., & Subudhi, U. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05712 · Cited by 39
A lesson from a saboteur: High‐MW kininogen impact in coronavirus‐induced disease 2019
Colarusso, C., Terlizzi, M., Pinto, A., & Sorrentino, R. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15154 · Cited by 38
Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
Huang, B., Niu, Y., Zhao, W., Bao, P., & Li, D. (2020) · Nature and Science of Sleep · doi:10.2147/nss.s263488 · Cited by 38
Delgado, J., Hernandez‐Alias, X., Cianferoni, D., & Serrano, L. G. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008450 · Cited by 39
An Immune Epigenetic Insight to COVID-19 Infection
Jit, B. P., Qazi, S., Arya, R. K., Srivastava, A., Gupta, N., & Sharma, A. K. (2021) · Epigenomics · doi:10.2217/epi-2020-0349 · Cited by 37
RAAS, ACE2 and COVID-19; a mechanistic review
Elshafei, A., Khidr, E. G., El-Husseiny, A. A., & Gomaa, M. H. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.07.003 · Cited by 37
Cadegiani, F. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00136.2020 · Cited by 34
Babadaei, M. M. N., Hasan, A., Bloukh, S. H., Edis, Z., Sharifi, M., Kachooei, E., & Falahati, M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1767211 · Cited by 39
Sars-CoV-2 and black population: ACE2 as shield or blade?
Vinciguerra, M., & Greco, E. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104361 · Cited by 35
Angiotensin-Converting Enzyme 2 as a Possible Correlation between COVID-19 and Periodontal Disease
Mancini, L., Quinzi, V., Mummolo, S., Marzo, G., & Marchetti, E. (2020) · Applied Sciences · doi:10.3390/app10186224 · Cited by 35
Dan, S., Pant, M., & Upadhyay, S. K. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-020-00239-0 · Cited by 35
Meningitis as an Initial Presentation of COVID-19: A Case Report
Naz, S., Hanif, M., Haider, M. A., Ali, M. J., Ahmed, M. U., & Saleem, S. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00474 · Cited by 35
The Molecular Basis of COVID-19 Pathogenesis, Conventional and Nanomedicine Therapy
Kouhpayeh, S., Shariati, L., Boshtam, M., Rahimmanesh, I., Mirian, M., Esmaeili, Y., Najaflu, M., Khanahmad, N., Zeinalian, M., Trovato, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115438 · Cited by 35
Thymus vulgaris, a natural pharmacy against COVID-19: A molecular review
Nadi, A., Shiravi, A. A., Mohammadi, Z. S., Amin, A., & Zeinalian, M. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100635 · Cited by 36
Xu, L., Mao, Y., & Chen, G. (2020) · medRxiv · doi:10.1101/2020.03.30.20047415 · Cited by 35
Zhou, L., Niu, Z., Jiang, X., Zhang, Z., Zheng, Y. Y., Wang, Z., Zhu, Y., Gao, L., Huang, H., Wang, X., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.06.028522 · Cited by 35
Pathomorphology of a new coronavirus infection COVID-19
Lobanova, O., Trusova, D. S., Rudenko, Е. Е., Проценко, Д. Д., & Коган, Е. А. (2020) · Сибирский журнал клинической и экспериментальной медицины · doi:10.29001/2073-8552-2020-35-3-47-52 · Cited by 35
Cold atmospheric plasma for preventing infection of viruses that use ACE2 for entry
Wang, P., Zhou, R., Zhou, R., Li, W., Weerasinghe, J., Chen, S., Rehm, B. H. A., Zhao, L., Frentiu, F. D., Zhang, Z., et al. (2022) · Theranostics · doi:10.7150/thno.70098 · Cited by 35
Rajarshi, K., Khan, R., Singh, M., Ranjan, T., Ray, S., & Ray, S. (2020) · Gene · doi:10.1016/j.gene.2020.145313 · Cited by 32
Karaderi, T., Bareke, H., Kunter, İ., Şeytanoğlu, A., Çağnan, I., Balcı, D., Barin, B., Hocaoğlu, M., Rahmioğlu, N., Asilmaz, E., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.586111 · Cited by 34
The Double Edge Sword of Testosterone’s Role in the COVID-19 Pandemic
Younis, J. S., Skorecki, K. L., & Abassi, Z. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.607179 · Cited by 32
Chen, Y., Shan, K.-J., & Qian, W. (2020) · Preprints.org · doi:10.20944/preprints202002.0258.v1 · Cited by 34
Clinical outcomes of 402 patients with COVID‐2019 from a single center in Wuhan, China
Wu, Y., Guo, W., Liu, H., Qi, B., Liang, K., Xu, H., Peng, Z., & Xiao, S. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26168 · Cited by 33
Ten challenging questions about SARS-CoV-2 and COVID-19
Teymoori‐Rad, M., Samadizadeh, S., Tabarraei, A., Moradi, A., Shahbaz, M. B., & Tahamtan, A. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1782197 · Cited by 30
Neurological Consequences of 2019-nCoV Infection: A Comprehensive Literature Review
Azim, D., Nasim, S., Kumar, S., Hussain, A., & Patel, S. (2020) · Cureus · doi:10.7759/cureus.8790 · Cited by 33
Potential Drugs and Remedies for the Treatment of COVID-19: a Critical Review
Barati, F., Pouresmaieli, M., Ekrami, E., Asghari, S., Ziarani, F. R., & Mamoudifard, M. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00129-1 · Cited by 33
Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19
Medzikovic, L., Cunningham, C. M., Li, M., Amjedi, M., Hong, J. S., Ruffenach, G., & Eghbali, M. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.08.007 · Cited by 33
COVID-19 clinical outcomes and nationality: results from a Nationwide registry in Kuwait
Hamadah, H., Alahmad, B., Behbehani, M., Al‐Youha, S., Almazeedi, S. M., Al‐Haddad, M., Jamal, M. H., & Al-Sabah, S. K. (2020) · BMC Public Health · doi:10.1186/s12889-020-09490-y · Cited by 34
County-level longitudinal clustering of COVID-19 mortality to incidence ratio in the United States
Vahabi, N., Salehi, M., Duarte, J. D., Mollalo, A., & Michailidis, G. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-82384-0 · Cited by 33
The probable destructive mechanisms behind COVID-19 on male reproduction system and fertility
Moshrefi, M., Ghasemi‐Esmailabad, S., Ali, J., Fındıklı, N., Mangoli, E., & Khalili, M. A. (2021) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-021-02097-1 · Cited by 34
Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19
Orienti, I., Gentilomi, G. A., & Farruggia, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113812 · Cited by 32
Biesalski, H. K. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000700 · Cited by 33
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
Kashyap, P., Thakur, M., Singh, N., Shikha, D., Kumar, S., Baniwal, P., Yadav, Y. S., Sharma, M., Sridhar, K., & Inbaraj, B. S. (2022) · Molecules · doi:10.3390/molecules27196374 · Cited by 34
A single-cell RNA expression map of human coronavirus entry factorsPreprint
Singh, M., Bansal, V., & Feschotte, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.08.084806 · Cited by 33
Why is SARS-CoV-2 infection milder among children?
Palmeira, P., Barbuto, J. A. M., Silva, C. A., & Carneiro-Sampaio, M. M. S. (2020) · Clinics · doi:10.6061/clinics/2020/e1947 · Cited by 32
Veselova, E. I., Russkikh, A., Kaminskiy, G., loVACheVA, O. V., Samoylova, А. G., & Vasilyeva, I. A. (2020) · Tuberculosis and lung diseases · doi:10.21292/2075-1230-2020-98-4-6-14 · Cited by 33
Severe COVID-19: Immunosuppression or Hyperinflammation?
Liu, Y., Li, Y., Xu, D., Zhang, J., & Peng, Z. (2021) · Shock · doi:10.1097/shk.0000000000001724 · Cited by 33
Rehman, S. U., & Tabish, M. (2020) · Clinical Science · doi:10.1042/cs20200419 · Cited by 31
Prezioso, C., Marcocci, M. E., Palamara, A. T., Chiara, G. D., & Pietropaolo, V. (2020) · Journal of NeuroVirology · doi:10.1007/s13365-020-00862-z · Cited by 30
Doença de Coronavírus-19 e o Miocárdio
de Figueiredo, J. A., Marcondes‐Braga, F. G., Moura, L. Z., de Figueiredo, A. M. E. S., de Figueiredo, V. M. E. S., Mourilhe‐Rocha, R., & Mesquita, E. T. (2020) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20200373 · Cited by 36
Review of potential risk groups for coronavirus disease 2019 (COVID-19)
Naveed, M., Naeem, M., Rahman, M. U., Hilal, M. G., Kakakhel, M. A., Ali, G., & Hassan, A. (2021) · New Microbes and New Infections · doi:10.1016/j.nmni.2021.100849 · Cited by 34
Khoury, E. E., Knaney, Y., Fokra, A., Kinaneh, S., Azzam, Z. S., Heyman, S. N., & Abassi, Z. A. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16310 · Cited by 28
Elemam, N. M., Hasswan, H., Aljaibeji, H., & Sulaiman, N. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105263 · Cited by 31
Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women
Rehman, S., Ravinayagam, V., Nahvi, I., Al-Dossary, H. A., AlShammari, M. M., Amiri, M. S. A., Kishore, U., & Al-Suhaimi, E. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680845 · Cited by 33
COVID-19: the new challenge for rheumatologists
Belov, B. S., & Karateev, A. E. (2020) · Modern Rheumatology Journal · doi:10.14412/1996-7012-2020-2-110-116 · Cited by 29
Children and COVID‐19: Microbiological and immunological insights
Buonsenso, D., Sali, M., Pata, D., Rose, C. D., Sanguinetti, M., Valentini, P., & Delogu, G. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24978 · Cited by 29
Koca, C., Civas, M., Sahin, S. M., Ergönül, Ö., & Akan, Ö. B. (2021) · IEEE Transactions on Molecular Biological and Multi-Scale Communications · doi:10.1109/tmbmc.2021.3071748 · Cited by 29
Atabati, E., Dehghani-Samani, A., & Moghaddam, S. G. M. (2020) · Canadian Journal of Respiratory Therapy · doi:10.29390/cjrt-2020-021 · Cited by 31
Gupta, A., Ahmad, R., Siddiqui, S., Yadav, K., Srivastava, A., Trivedi, A., Ahmad, B., Khan, M. A., Shrivastava, A. K., & Singh, G. K. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1871863 · Cited by 29
Old and new antirheumatic drugs for the treatment of COVID-19
Benucci, M., Damiani, A., Infantino, M. G., Manfredi, M., & Quartuccio, L. (2020) · Joint Bone Spine · doi:10.1016/j.jbspin.2020.03.013 · Cited by 28
A gendered magnifying glass on COVID-19
Salvati, L., Biagioni, B., Vivarelli, E., & Parronchi, P. (2020) · Clinical and Molecular Allergy · doi:10.1186/s12948-020-00129-2 · Cited by 31
The Frequency of Neurological Symptoms in COVID-19 Patients at a Tertiary Care Hospital in Pakistan
Makda, A., Kumar, S., Kumar, A., Kumar, V., & Rizwan, A. (2020) · Cureus · doi:10.7759/cureus.10360 · Cited by 29
Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system
Wang, N., Qin, L., Ma, L., & Yan, H. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102189 · Cited by 28
Gadanec, L. K., Qaradakhi, T., McSweeney, K. R., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021) · Future Microbiology · doi:10.2217/fmb-2021-0018 · Cited by 29
Chen, H., Xuan, B., Yan, Y., Zhu, X., Shen, C., Zhao, G., Ji, L., Xu, D., Xiong, H., Yu, T., et al. (2020) · medRxiv · doi:10.1101/2020.02.15.20023457 · Cited by 29
Quan, W., Chen, J., Liu, Z., Tian, J., Chen, X., Wu, T., Ji, Z., Tang, J., Chu, H., Xu, H., et al. (2020) · medRxiv · doi:10.1101/2020.03.26.20044198 · Cited by 28
Self-citationPolymorphisms in the ACE2 Locus Associate with Severity of COVID-19 InfectionPreprint
Wooster, L. T., Nicholson, C., Sigurslid, H. H., Cardenas, C. L. L., & Malhotra, R. K. (2020) · medRxiv · doi:10.1101/2020.06.18.20135152 · Cited by 28
Maldonado, V., Loza-Mejía, M. A., & Chávez, J. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109988 · Cited by 29
Is COVID-19 Similar in Pregnant and Non-Pregnant Women?
Selim, M. F., Mohamed, S. A. A., Abdo, M., & Abdelhaffez, A. (2020) · Cureus · doi:10.7759/cureus.8888 · Cited by 28
COVID-19: inflammatory responses, structure-based drug design and potential therapeutics
Tripathi, N., Tripathi, N., & Goshisht, M. K. (2021) · Molecular Diversity · doi:10.1007/s11030-020-10176-1 · Cited by 29
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2
Wang, Y., Fan, Y., Huang, Y., Du, T., Liu, Z., Huang, D., Wang, Y., Wang, N., & Zhang, P. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110064 · Cited by 27
Self-citationTriaging Total Hip Arthroplasty During the COVID-19 Pandemic
Rizkalla, J., Gladnick, B. P., Bhimani, A. A., Wood, D. S., Kitziger, K. J., & Peters, P. C. (2020) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-020-09642-y · Cited by 26
Saeed, A., & Shorafa, E. (2020) · IDCases · doi:10.1016/j.idcr.2020.e00942 · Cited by 27
Gastrointestinal pathophysiology of SARS-CoV2 – a literature review
Syed, A., Khan, A., Gosai, F., Asif, A. A., & Dhillon, S. (2020) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.1080/20009666.2020.1811556 · Cited by 27
Bianco, G. L., Pietro, S. D., Mazzuca, E., Imburgia, A., Tarantino, L., Accurso, G., Benenati, V., Vernuccio, F., Bucolo, C., Salomone, S., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.572168 · Cited by 29
DNA methylation architecture of the ACE2 gene in nasal cells of children
Cárdenas, A., Rifas‐Shiman, S. L., Sordillo, J. E., DeMeo, D. L., Baccarelli, A., Hivert, M., Gold, D. R., & Oken, E. (2021) · Scientific Reports · doi:10.1038/s41598-021-86494-7 · Cited by 26
Sars-Cov-2 Infects an Upper Airway Model Derived from Induced Pluripotent Stem Cells
Djidrovski, I., Γεωργίου, Μ., Hughes, G. L., Patterson, E. I., Casas-Sánchez, A., Pennington, S. H., Biagini, G. A., Molina, M. M., van den Bor, J., Smit, M. J., et al. (2021) · Stem Cells · doi:10.1002/stem.3422 · Cited by 23
How Did Chinese Government Implement Unconventional Measures Against COVID-19 Pneumonia
Yu, X., & Li, N. (2020) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s251351 · Cited by 26
Zhu, J., Deng, Y.-Q., Wang, X., Li, X.-F., Zhang, N.-N., Liu, Z.-R., Zhang, B., Qin, C.-F., & Xie, Z. (2020) · bioRxiv · doi:10.1101/2020.05.02.074021 · Cited by 29
Epidemiological analysis of the early 38 fatalities in Hubei, China, of the coronavirus disease 2019
Chen, Y., Zhao, M., Wu, Y., & Zang, S. (2020) · Journal of Global Health · doi:10.7189/jogh.10.011004 · Cited by 25
Merits and culprits of immunotherapies for neurological diseases in times of COVID-19
Pawlitzki, M., Zettl, U. K., Ruck, T., Rolfes, L., Hartung, H.-P., & Meuth, S. G. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102822 · Cited by 26
SARS-CoV-2: An Overview of Virus Genetics, Transmission, and Immunopathogenesis
Farrag, M. A., Amer, H. M., Bhat, R., Hamed, M. E., Aziz, I. M., Mubarak, A., Dawoud, T. M. S., Almalki, S. G., Alghofaili, F., Alnemare, A. K., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126312 · Cited by 28
Murugan, C., Ramamoorthy, S., Kuppuswamy, G. P., Murugan, R. K., Sivalingam, Y., & Sundaramurthy, A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.144 · Cited by 28
Puzzle of highly pathogenic human coronaviruses (2019-nCoV)
Li, J., & Liu, W. (2020) · Protein & Cell · doi:10.1007/s13238-020-00693-y · Cited by 24
Inpatient Care of Patients with COVID-19: A Guide for Hospitalists
Yetmar, Z. A., Issa, M., Munawar, S., Burton, M. C., Pureza, V. S., Sohail, M. R., & Mehmood, T. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.03.041 · Cited by 25
Fulminant Acute Kidney Injury in a Young Patient with Novel Coronavirus 2019
Gopalakrishnan, A., Mossaid, A., Lo, K. B., Vasudevan, V. P., McCullough, P. A., & Rangaswami, J. (2020) · Cardiorenal Medicine · doi:10.1159/000508179 · Cited by 24
Acute kidney injury in COVID-19; a review on current knowledge
Aleebrahim‐Dehkordi, E., Reyhanian, A., Saberianpour, S., & Dehkordi, A. H. (2020) · Journal of Nephropathology · doi:10.34172/jnp.2020.31 · Cited by 24
Coronavirus disease 2019 and cardiovascular implications
Frattini, S., Maccagni, G., Italia, L., Metra, M., & Danzi, G. B. (2020) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001068 · Cited by 24
Design of an engineered ACE2 as a novel therapeutics against COVID-19
Payandeh, Z., Rahbar, M. R., Jahangiri, A., Hashemi, Z. S., Zakeri, A., Jafarisani, M., Rasaee, M. J., & Khalili, S. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110425 · Cited by 25
Pengaruh Gender Dan Manifestasi Kardiovaskular Pada COVID-19
Sarvasti, D. (2020) · Indonesian Journal of Cardiology · doi:10.30701/ijc.1004 · Cited by 23
Barón-Sánchez, J., Santiago, C., Martín, G. G.-S., Arca, R., & Fernández, R. (2020) · Neurología · doi:10.1016/j.nrl.2020.07.006 · Cited by 30
Metadata
- Authors
- Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., & Zuo, W.
- Affiliations
- Tongji University (CN)
- Regend Therapeutics (China) (CN)
- Corresponding author
- Zuo, Wei
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2020-01-26
- OpenAlex
- W3003154936
- Cited by
- 860
- References
- 20
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 19 · 2022: 56 · 2021: 194 · 2020: 576
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- ACE2, SARS-CoV-2, COVID-19 pandemic, single-cell RNA sequencing, alveolar type II cells, lung tissue, viral receptor expression, SARS-CoV
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review