Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Clinical characteristics of coronavirus disease 2019 in China

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Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

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Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

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Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes

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Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion ConformationPreprint

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Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Will children reveal their secret? The coronavirus dilemma

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The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS‐CoV‐2 infection

Shen, Q., Xiao, X., Aierken, A., Yue, W., Wu, X., Liao, M., & Hua, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15541 · Cited by 206

Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking

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Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

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SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease

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Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran

Shahriarirad, R., Khodamoradi, Z., Erfani, A., Hosseinpour, H., Ranjbar, K., Emami, Y., Mirahmadizadeh, A., Lotfi, M., Yeganeh, B. S., Nejad, A. D., et al. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05128-x · Cited by 178

Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis

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Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

Zhang, X., Zhang, Y., Qiao, W., Zhang, J., & Qi, Z. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106749 · Cited by 182

Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists

Jin, H., Hong, C., Chen, S., Zhou, Y., Wang, Y., Mao, L., Li, Y., He, Q., Li, M., Su, Y., et al. (2020) · Stroke and Vascular Neurology · doi:10.1136/svn-2020-000382 · Cited by 174

Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies

Lopes‐Pacheco, M., Silva, P. L., Cruz, F. F., Battaglini, D., Robba, C., Pelosi, P. P., Morales, M. M., Neves, C. C., & Rocco, P. R. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.593223 · Cited by 178

Microstructure, pathophysiology, and potential therapeutics of COVID‐19: A comprehensive review

Singh, S. P., Pritam, M., Pandey, B., & Yadav, T. P. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26254 · Cited by 166

Psychological, addictive, and health behavior implications of the COVID-19 pandemic

Zvolensky, M. J., Garey, L., Rogers, A. H., Schmidt, N. B., Vujanovic, A. A., Storch, E. A., Buckner, J. D., Paulus, D. J., Alfano, C. A., Smits, J. A. J., et al. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103715 · Cited by 175

Will children reveal their secret? The coronavirus dilemma

Midulla, F., Cristiani, L., & Mancino, E. (2020) · European Respiratory Journal · doi:10.1183/13993003.01617-2020 · Cited by 158

Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics

Arshad, U., Pertinez, H. E., Box, H., Tatham, L. M., Rajoli, R. K. R., Curley, P., Neary, M., Sharp, J., Liptrott, N. J., Valentijn, A., et al. (2020) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1909 · Cited by 153

Liver diseases in COVID-19: Etiology, treatment and prognosis

Wu, J., Song, S., Cao, H., & Li, L.-J. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i19.2286 · Cited by 155

The SARS-CoV-2 and mental health: From biological mechanisms to social consequences

Szcześniak, D. M., Gładka, A., Misiak, B., Cyran, A., & Rymaszewska, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110046 · Cited by 157

Diarrhea Is Associated With Prolonged Symptoms and Viral Carriage in Corona Virus Disease 2019

Wei, X., Wang, X., Niu, Y., Ye, L.-L., Peng, W.-B., Wang, Z.-H., Yang, W.-B., Yang, B., Zhang, J.-C., Ma, W., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.04.030 · Cited by 148

Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports

Rahimi, K. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04693-y · Cited by 149

Headache characteristics in COVID-19 pandemic-a survey study

Uygun, Ö., Ertaş, M., Ekizoğlu, E., Bolay, H., Özge, A., Orhan, E. K., Çağatay, A. A., & Baykan, B. B. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01188-1 · Cited by 150

New Insights of Emerging SARS-CoV-2: Epidemiology, Etiology, Clinical Features, Clinical Treatment, and Prevention

Guo, G., Ye, L., Pan, K., Chen, Y. Z., Xing, D., Yan, K., Chen, Z., Ding, N., Li, W., Huang, H., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00410 · Cited by 147

Neurological manifestations and implications of COVID-19 pandemic

Tsivgoulis, G., Palaiodimou, L., Katsanos, A. H., Caso, V., Köhrmann, M., Molina, C., Cordonnier, C., Fischer, U., Kelly, P., Sharma, V. K., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420932036 · Cited by 145

Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections

Quesada‐Gómez, J. M., Castillo, M. E., & Bouillon, R. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105719 · Cited by 151

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

Gadanec, L. K., McSweeney, K. R., Qaradakhi, T., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030992 · Cited by 147

Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics

Qin, H., & Zhao, A. (2020) · Protein & Cell · doi:10.1007/s13238-020-00738-2 · Cited by 147

COVID‐19 and non‐alcoholic fatty liver disease: Two intersecting pandemics

Portincasa, P., Krawczyk, M. J., Smyk, W., Lammert, F., & Ciaula, A. D. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13338 · Cited by 141

Potential Causes and Consequences of Gastrointestinal Disorders during a SARS-CoV-2 Infection

Trottein, F., & Sokol, H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107915 · Cited by 141

Frequent Convulsive Seizures in an Adult Patient with COVID-19: A Case Report

Karimi, N., Razavi, A. S., & Rouhani, N. (2020) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.102828 · Cited by 141

Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis

Alexpandi, R., Mesquita, J. F. D., Pandian, S. K., & Ravi, A. V. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01796 · Cited by 144

Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study

Liu, J., Zhang, S., Wu, Z., Shang, Y., Dong, X., Li, G., Zhang, L., Chen, Y., Ye, X., Du, H., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00706-3 · Cited by 141

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

Shirbhate, E., Pandey, J., Patel, V. K., Kamal, M., Jawaid, T., Gorain, B., Kesharwani, P., & Rajak, H. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00303-6 · Cited by 164

Extracellular vesicle‐mediated endothelial apoptosis and EV‐associated proteins correlate with COVID‐19 disease severity

Krishnamachary, B., Cook, C. M., Kumar, A., Spikes, L. A., Chalise, P., & Dhillon, N. K. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12117 · Cited by 140

Coronavirus disease (COVID-19): a scoping review

Lv, M., Luo, X., Estill, J., Liu, Y., Ren, M., Wang, J., Wang, Q., Zhao, S., Wang, X., Yang, S., et al. (2020) · Eurosurveillance · doi:10.2807/1560-7917.es.2020.25.15.2000125 · Cited by 122

The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection

Qi, J., Zhou, Y., Hua, J., Zhang, L., Bian, J., Liu, B., Zhao, Z., & Jin, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010284 · Cited by 135

ACE2 and COVID-19 and the resulting ARDS

Zhang, X., Li, S., & Niu, S. (2020) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2020-137935 · Cited by 137

Severe COVID-19 and aging: are monocytes the key?

Pence, B. D. (2020) · GeroScience · doi:10.1007/s11357-020-00213-0 · Cited by 137

Ultra-fast and onsite interrogation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in waters via surface enhanced Raman scattering (SERS)

Zhang, D., Zhang, X., Ma, R., Deng, S., Wang, X., Wang, X., Zhang, X., Huang, X., Liu, Y., Li, G., et al. (2021) · Water Research · doi:10.1016/j.watres.2021.117243 · Cited by 131

On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges

Sivasankarapillai, V. S., Pillai, A. M., Rahdar, A., Anumol, P. S., Das, S. S., Mitrοpoulos, A. C., Mokarrar, M. H., & Kyzas, G. Z. (2020) · Nanomaterials · doi:10.3390/nano10050852 · Cited by 131

Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators

Gkogkou, E., Barnasas, G., Vougas, K. N., & Trougakos, I. P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101615 · Cited by 134

Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCovPreprint

Cai, G. (2020) · medRxiv · doi:10.1101/2020.02.05.20020107 · Cited by 128

Chronological Changes of Viral Shedding in Adult Inpatients With COVID-19 in Wuhan, China

Huang, J., Ran, R., Lv, Z., Feng, L., Ran, C.-Y., Tong, Y., Dong, L., Su, H., Zhu, C., Qiu, S., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa631 · Cited by 126

Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity of Scutellaria baicalensis Georgi. and its probably potential therapeutic effects on COVID-19: a review

Song, J., Long, J., Xie, L., Zhang, L., Xie, Q., Chen, H., Deng, M., & Li, X. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00384-0 · Cited by 131

SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review

Fathizadeh, H., Afshar, S., Masoudi, M. R., Gholizadeh, P., Asgharzadeh, M., Ganbarov, K., Köse, Ş., Yousefi, M., & Kafil, H. S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.076 · Cited by 126

Scientific research progress of COVID‐19/SARS‐CoV‐2 in the first five months

Li, H., Liu, Z., & Ge, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15364 · Cited by 127

Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors

Singh, R., Bhardwaj, V. K., Sharma, J., Kumar, D., & Purohit, R. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104631 · Cited by 117

Risk factors for 2019 novel coronavirus disease (COVID-19) patients progressing to critical illness: a systematic review and meta-analysis

Xu, L., Mao, Y., & Chen, G. (2020) · Aging · doi:10.18632/aging.103383 · Cited by 149

Main Clinical Features of COVID-19 and Potential Prognostic and Therapeutic Value of the Microbiota in SARS-CoV-2 Infections

He, Y., Wang, J., Li, F., & Shi, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01302 · Cited by 114

Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor

Pan, B., Fang, S., Zhang, J., Pan, Y., Liu, H., Wang, Y., Li, M., & Liu, L. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.11.010 · Cited by 116

Smoking and COVID-19: What we know so far

Shastri, M. D., Shukla, S. D., Chong, W. C., Rajendra, K. C., Dua, K., Patel, R. P., Peterson, G. M., & O’Toole, R. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2020.106237 · Cited by 110

Severe COVID-19: A Review of Recent Progress With a Look Toward the Future

Xie, P., Ma, W., Tang, H., & Liu, D. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00189 · Cited by 118

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

van Haren, F. M. P., Page, C. P., Laffey, J. G., Artigas, A., Camprubí–Rimblas, M., Nunes, Q. M., Smith, R. J., Shute, J. K., Carroll, M., Tree, J. A., et al. (2020) · Critical Care · doi:10.1186/s13054-020-03148-2 · Cited by 114

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Qin, Z., Liu, F., Blair, R. V., Wang, C., Yang, H., Mudd, J. C., Currey, J. M., Iwanaga, N., He, J., Mi, R., et al. (2021) · Theranostics · doi:10.7150/thno.61810 · Cited by 116

Shorter telomere lengths in patients with severe COVID-19 disease

Sánchez-Vazquez, R., Guío-Carrión, A., Zapatero, A., Martínez, P., & Blasco, M. A. (2021) · Aging · doi:10.18632/aging.202463 · Cited by 110

Novel coronavirus infection in children outside of Wuhan, China

Shen, Q., Guo, W., Guo, T., Li, J., He, W., Ni, S., Ouyang, X., Liu, J., Xie, Y., Tan, X., et al. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24762 · Cited by 109

COVID-19 and cerebrovascular diseases: a comprehensive overview

Tsivgoulis, G. K., Palaiodimou, L., Zand, R., Lioutas, V., Krogias, C., Katsanos, A. H., Shoamanesh, A., Sharma, V. K., Shahjouei, S., Baracchini, C., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420978004 · Cited by 112

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

Chow, R. D.-W., Majety, M., & Chen, S. (2021) · Nature Communications · doi:10.1038/s41467-020-20323-9 · Cited by 106

Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines

dos Santos, W. G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111272 · Cited by 108

COVID-19, cytokines, inflammation, and spices: How are they related?

Kunnumakkara, A. B., Rana, V., Parama, D., Banik, K., Girisa, S., Henamayee, S., Thakur, K. K., Dutta, U., Garodia, P., Gupta, S. C., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119201 · Cited by 107

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung OrganoidsPreprint

Han, Y., Yang, L., Duan, X., Duan, F., Nilsson-Payant, B. E., Yaron, T. M., Wang, P., Tang, X., Zhang, T., Zhao, Z., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.05.079095 · Cited by 107

Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2

Breiman, A., Ruvoën‐Clouet, N., & LePendu, J. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008556 · Cited by 106

Smoking and COVID-19: Adding Fuel to the Flame

Kashyap, V. K., Dhasmana, A., Massey, A. E., Kotnala, S., Zafar, N., Jaggi, M., Yallapu, M. M., & Chauhan, S. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186581 · Cited by 108

Targeting Proteases for Treating COVID-19

Luan, B., Huynh, T., Cheng, X. M., Lan, G., & Wang, H. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00430 · Cited by 109

The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions

Behl, T., Kaur, I., BUNGAU, S. G., Kumar, A., Uddin, M. S., Kumar, C., Pal, G., Sahil, Shrivastava, K., Zengin, G., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118075 · Cited by 105

In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2

Hiremath, S. S., Kumar, H. D. V., Nandan, M., Mantesh, M., Shankarappa, K. S., Venkataravanappa, V., Basha, C. R. J., & Reddy, C. N. L. (2021) · 3 Biotech · doi:10.1007/s13205-020-02578-7 · Cited by 105

Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients

Osman, I. O., Melenotte, C., Brouqui, P., Million, M., Lagier, J., Parola, P., Stein, A., Scola, B. L., Meddeb, L., Mège, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625732 · Cited by 103

Sex‐related differences in COVID‐19 lethality

Penna, C. R. R., Mercurio, V., Tocchetti, C. G., & Pagliaro, P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15207 · Cited by 109

Insight into COVID‐2019 for pediatricians

Li, Y., Guo, F., Cao, Y., Li, L., & Guo, Y. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24734 · Cited by 100

Potential 2019-nCoV 3C-like Protease Inhibitors Designed Using Generative Deep Learning ApproachesPreprint

Zhavoronkov, A., Aladinskiy, V., Zhebrak, A., Zagribelnyy, B. A., Terentiev, V. A., Bezrukov, D., Polykovskiy, D. A., Shayakhmetov, R., Filimonov, A., Orekhov, P., et al. (2020) · ChemRxiv · doi:10.26434/chemrxiv.11829102.v1 · Cited by 108

Organoids: a novel modality in disease modeling

Heydari, Z., Moeinvaziri, F., Agarwal, T., Pooyan, P., Shpichka, A. I., Maiti, T. K., Timashev, P. S., Baharvand, H., & Vosough, M. (2021) · Bio-Design and Manufacturing · doi:10.1007/s42242-021-00150-7 · Cited by 106

Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?

Wallace, T. C. (2020) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1785971 · Cited by 102

COVID-19: Why does disease severity vary among individuals?

Samadizadeh, S., Masoudi, M., Rastegar, M., Salimi, V., Shahbaz, M. B., & Tahamtan, A. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2021.106356 · Cited by 100

Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants

da Costa, C. H. S., de Freitas, C. A. B., Alves, C. N., & Lameira, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-12479-9 · Cited by 101

Statistical and network analysis of 1212 COVID-19 patients in Henan, China

Wang, P., Lu, J.-A., Jin, Y., Zhu, M., Wang, L., & Chen, S. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.04.051 · Cited by 96

Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells

Baig, M. S., Alagumuthu, M., Rajpoot, S., & Saqib, U. (2020) · Drugs in R&D · doi:10.1007/s40268-020-00312-5 · Cited by 96

Stroke as a complication and prognostic factor of COVID-19

Trejo-Gabriel-Galan, J. M. (2020) · Neurología (English Edition) · doi:10.1016/j.nrleng.2020.04.013 · Cited by 94

Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)

Nadeem, M. S., Zamzami, M. A., Choudhry, H., Murtaza, B. N., Kazmi, I. A., Ahmad, H., & Shakoori, A. R. (2020) · Pathogens · doi:10.3390/pathogens9040307 · Cited by 95

Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients

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Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2

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