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Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak
Open accessAbstract
Background: Recent surge of olfactory dysfunction in patients who were referred to ENT clinics and concurrent COVID-19epidemic in Iran motivated us to evaluate anosmic/hyposmic patients to find any relation between these two events. Methods: This is a cross-sectional study with an online checklist on voluntary cases in all provinces of Iran between the 12th and 17th March, 2020. Cases was defined as self-reported anosmia/hyposmia in responders fewer than 4 weeks later (from start the of COVID-19 epidemic in Iran). Variables consist of clinical presentations, related past medical history, family history of recent respiratory tract infection and hospitalization. Results: In this study 10069 participants aged 32.5±8.6 (7-78) years, 71.13% female and 81.68% non-smoker completed online checklist. They reported 10.55% a history of a trip out of home town and 1.1% hospitalization due to respiratory problems recently. From family members 12.17% had a history of severe respiratory disease in recent days and 48.23% had anosmia/hyposmia. Correlation between the number of olfactory disorder and reported COVID-19 patients in all 31 provinces till 16th March 2020 was highly significant (Spearman correlation coefficient=0.87, p-Value<0.001). The onset of anosmia was sudden in 76.24% and till the time of filling the questionnaire in 60.90% of patients decreased sense of smell was constant. Also 83.38 of this patients had decreased taste sensation in association with anosmia. Conclusions: It seems that we have a surge in outbreak of olfactory dysfunction happened in Iran during the COVID-19 epidemic. The exact mechanism of anosmia/hyposmia in COVID-19 patients’ needs further investigations.
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“Clinical reports suggest that infection with CoV-2 is associated with high rates of disturbances in smell and taste perception, including anosmia (8-13).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [8]
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Metadata
- Authors
- Bagheri, S. H., Asghari, A., Farhadi, M., Shamshiri, A. R., Kabir, A., Kamrava, S. K., Jalessi, M., Mohebbi, A., Alizadeh, R., Honarmand, A. A., Ghalehbaghi, B., & Salimi, A.
- Affiliations
- Iran University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Iran Medical Council (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Corresponding author
- Ghalehbaghi, Babak
- ORCID
- Venue
- medRxiv
- Publisher
- openRxiv
- Published
- 2020-03-27
- OpenAlex
- W3013558447
- Cited by
- 179
- References
- 13
- Citations by year
- 2023: 7 · 2022: 11 · 2021: 47 · 2020: 114
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- medRxiv (acceptedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Dermatology › Dermatological and COVID-19 studies
- Keywords
- COVID-19 pandemic, olfactory dysfunction, anosmia, hyposmia, ageusia, SARS-CoV-2, Iran, self-reported symptoms
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