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PreprintCited by 69Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

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Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

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Hansen, Justine Y., Markello, Ross D., Tuominen, Lauri, Nørgaard, Martin, Kuzmin, Elena, Palomero-Gallagher, Nicola, Dagher, Alain, Misic, Bratislav·2021·NeuroImage
DOI 10.1101/2021.11.30.469876

Preprint — published as 10.1016/j.neuroimage.2022.119671 · Paper page

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Abstract

Neurotransmitter receptors modulate the signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression is often used as a proxy for receptor densities. In the present report, we comprehensively test the expression-density association for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT 1A , D 2 , CB 1 , and MOR). These expression-density associations are related to population variance and change across different classes of laminar differentiation. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function.

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Metadata

Authors
Hansen, J. Y., Markello, R. D., Tuominen, L., Nørgaard, M., Kuzmin, E., Palomero-Gallagher, N., Dagher, A., & Misic, B.
Affiliations
  • Montreal Neurological Institute and Hospital (CA)
  • University of Ottawa (CA)
  • Copenhagen University Hospital (DK)
  • Institut du cancer Rosalind & Morris Goodman (CA)
Corresponding author
Hansen, Justine Y.
ORCID
Venue
NeuroImage
Publisher
openRxiv
Published
2021-12-02
Volume
264
Pages
119671-119671
ISSN
1053-8119 (ISSN-L)
DOI
10.1101/2021.11.30.469876
OpenAlex
W4302424620
Cited by
69
References
2
Citations by year
2026: 15 · 2025: 18 · 2024: 17 · 2023: 12 · 2022: 7
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • NeuroImage (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen)
Funders
  • McGill University
  • Canada Research Chairs
  • Canada First Research Excellence Fund
  • Danmarks Frie Forskningsfond (DFF-0129-00004B)
  • Natural Sciences and Engineering Research Council of Canada (RGPIN #017–04265, 01704265)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
neurotransmitter receptors, neurotransmitter transporters, receptor density, gene expression, mRNA-protein correlation, autoradiography, metabotropic receptors, 5-HT1A receptor, CB1 receptor, dopamine D2 receptor, mu-opioid receptor, genetic stability, human brain
MeSH terms
Autoradiography, Brain, Carrier Proteins, Humans, Gene Expression, Receptors, Neurotransmitter, Neurotransmitter Agents

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