The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reconstructing Biological Molecules with Help from Video Gamers
Open accessPreprint — published as 10.1107/s2059798325008149
Abstract
Foldit is a citizen science video game in which players tackle a variety of complex biochemistry puzzles. Here, we describe a new series of puzzles in which Foldit players improve the accuracy of the public repository of experimental protein structure models, the Protein Data Bank (PDB). Analyzing the results of these puzzles showed that the Foldit players were able to considerably improve the deposited structures and thus, in most cases, improved the output of the automated PDB-REDO refinement pipeline. These improved structures are now being hosted at PDB-REDO. These efforts highlight the continued need for the engagement of the lay population in science.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Flagged first, then by citations
Research works printed but not linked: 17
- 10.1038/nsb1203-980 · DOI · Paper page
- 10.1107/S0907444908037591 · DOI
- 10.1016/j.str.2011.08.006 · DOI
- 10.1126/science.317.5835.195 · DOI
- 10.1002/pro.3353 · DOI
- 10.1107/S0907444911054515 · DOI
- 10.1038/nature09304 · DOI · Paper page
- 10.1038/s41592-020-0848-2 · DOI · Paper page
- F. Khatib et al., Building de novo cryo-electron microscopy structures collaboratively with citizen scientists. Plos Biol 17, (2019). · DOI
- 10.1107/S0907444909042073 · DOI · Paper page
- 10.1093/nar/gkq1105 · DOI
- 2023, Accurate proteome-wide missense variant effect prediction with AlphaMissense, Science, 381, 1303
- 2019, Macromolecular structure determination using X-rays, neutrons and electrons: recent developments, Acta Crystallogr D, 75, 861, 10.1107/S2059798319011471 · DOI · Paper page
- 10.1107/S1399004714028132 · DOI
- 10.1107/S2052252514009324 · DOI
- 10.1107/S0907444911001314 · DOI
- 10.1107/S0907444904023510 · DOI
Metadata
- Authors
- Petrides, A. C., Joosten, R. P., Players, F., Khatib, F., & Horowitz, S.
- Affiliations
- University of Massachusetts Dartmouth (US)
- The Netherlands Cancer Institute (NL)
- University of Denver (US)
- Corresponding author
- Horowitz, Scott
- Venue
- Acta Crystallographica Section D Structural Biology
- Publisher
- openRxiv
- Published
- 2024-06-21
- Volume
- 81
- Issue
- 11
- Pages
- 598-604
- ISSN
- 2059-7983 (ISSN-L)
- PMC
- PMC12576847
- OpenAlex
- W4414968624
- Cited by
- 1
- References
- 1
- Citations by year
- 2026: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Acta Crystallographica Section D Structural Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (2051305, 2051282)
- Ministerie van Volksgezondheid, Welzijn en Sport
- KWF Kankerbestrijding
- HORIZON EUROPE Framework Programme (871037)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Social Sciences › Sociology and Political Science › Digital Games and Media
- Keywords
- Foldit, citizen science, protein structure prediction, Protein Data Bank, video games, public engagement with science
- MeSH terms
- Models, Molecular, Protein Conformation, Proteins, Video Games, Databases, Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
