Cited by 85RNA Research and SplicingDNA Repair MechanismsCancer-related molecular mechanisms research

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

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Michelini, Flavia, Jalihal, Ameya P., Francia, Sofia, Meers, Chance, Neeb, Zachary T., Rossiello, Francesca, Gioia, Ubaldo, Aguado, Julio +8 more·2018·Chemical Reviews

Abstract

Coding for proteins has been considered the main function of RNA since the "central dogma" of biology was proposed. The discovery of noncoding transcripts shed light on additional roles of RNA, ranging from the support of polypeptide synthesis, to the assembly of subnuclear structures, to gene expression modulation. Cellular RNA has therefore been recognized as a central player in often unanticipated biological processes, including genomic stability. This ever-expanding list of functions inspired us to think of RNA as a "smart" phone, which has replaced the older obsolete "cellular" phone. In this review, we summarize the last two decades of advances in research on the interface between RNA biology and genome stability. We start with an account of the emergence of noncoding RNA, and then we discuss the involvement of RNA in DNA damage signaling and repair, telomere maintenance, and genomic rearrangements. We continue with the depiction of single-molecule RNA detection techniques, and we conclude by illustrating the possibilities of RNA modulation in hopes of creating or improving new therapies. The widespread biological functions of RNA have made this molecule a reoccurring theme in basic and translational research, warranting it the transcendence from classically studied "cellular" RNA to "smart" RNA.

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  • DDR activation depends on noncoding RNAs such as dilncRNA and DDRNA generated at exposed DNA ends, including dysfunctional telomeres.

    “The discovery that DDR activation depends on noncoding RNAs, such as damage-induced long non-coding RNAs (dilncRNA) and DNA damage-response RNAs (DDRNA), generated at exposed DNA ends, including dysfunctional telomeres, make such RNAs attractive targets for potential therapeutic interventions196.”

    From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [196]

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Authors
Michelini, F., Jalihal, A. P., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., Biamonti, G., Nowacki, M., Storici, F., Carninci, P., Walter, N. G., & d’Adda di Fagagna, F.
Affiliations
  • IFOM (IT)
  • University of Michigan (US)
  • Georgia Institute of Technology (US)
  • University of Bern (CH)
  • Johannes Gutenberg University Mainz (DE)
  • Istituto di Genetica Molecolare (IT)
  • RIKEN (JP)
  • IFOM − The FIRC Institute of Molecular Oncology, Milan, 20139, Italy
Corresponding author
Michelini, Flavia
Venue
Chemical Reviews
Published
2018-03-30
Volume
118
Issue
8
Pages
4365-4403
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2794746967
Cited by
85
References
418
Citations by year
2026: 10 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 4
FWCI
1.05
Type
journal article
Language
en
Open access
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • BORIS (University Library Bern) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • Howard Hughes Medical Institute (55108574)
  • Collegio Ghislieri di Pavia
  • Division of Molecular and Cellular Biosciences (MCB-1615335)
  • Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung (31003A_146257, 31003A_166407)
  • Associazione Italiana per la Ricerca sul Cancro (15273)
  • Fondazione Cariplo (2014-1215)
  • U.S. Department of Education (P200A150130-16)
  • Comprehensive Cancer Center, University of Michigan
  • FP7 Ideas: European Research Council (260358)
  • National Institute of General Medical Sciences (GM115927, GM122803, GM118524, GM062357)
  • H2020 European Research Council (681178)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
RNA, genome stability, non-coding RNA, DNA damage signaling, DNA repair, telomere maintenance, genome rearrangement, single-molecule RNA detection, RNA therapeutics
MeSH terms
DNA Damage, Gene Expression Regulation, Humans, Transcription, Genetic, RNA-Binding Proteins, RNA, Untranslated, RNA Interference, Genomic Instability, DNA Breaks, Double-Stranded

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