PreprintCited by 7Academic Writing and PublishingArtificial Intelligence ApplicationsScientific Computing and Data Management

DORA AI Scientist: Multi-agent Virtual Research Team for Scientific Exploration Discovery and Automated Report Generation

Open access
Naumov, Vladimir, Zagirova, Diana, Lin, Sha, Xie, Yupeng, Gou, Wenhao, Urban, Anatoly, Tikhonova, Nina, Alawi, Khadija +15 more·2025·bioRxiv (Cold Spring Harbor Laboratory)

Abstract

Abstract Modern goal-oriented scientific research process involves hierarchical teams of researchers of diverse backgrounds performing generalist and domain-specific tasks. Many of these tasks include hypothesis generation, literature review, data collection, cleanup, processing and analysis, experimental design, virtual and physical experiments, research report and academic paper writing, reference management, bibliography and quality control. Most of these tasks can be performed automatically or in a co-pilot mode by the generative reinforcement learning systems. In this paper, we introduce a versatile multi-agent scientific exploration and draft outline research assistant (DORA), which provides multiple templates and workflows for automated or semi-automated research studies and report generation. Under user guidance, it employs hierarchical teams of AI agents based on the plug-and-play generalist and domain-specific large language models (LLMs) exploiting a variety of specialized research tools and open data repositories and generates high-quality research outputs publication drafts with maximally-accurate references. DORA is designed to minimize the time and effort required for manuscript preparation, thereby enabling researchers to devote more attention to high-value discovery tasks. The system is constantly evolving with user feedback with regular feature and resource updates. The platform is available at https://dora.insilico.com .

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Registry

Crossref · 10.1101/2025.03.06.641840

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Authors
Naumov, V., Zagirova, D., Lin, S., Xie, Y., Gou, W., Urban, A., Tikhonova, N., Alawi, K., Durymanov, M., Galkin, F., Chen, S., Sidorenko, D., Korzinkin, M., Scheibye-Knudsen, M., Aspuru-Guzik, A., Izumchenko, E., Gennert, D., Pun, F. W., Zhang, M., Kamya, P., Aliper, A., Ren, F., & Zhavoronkov, A.
Affiliations
  • Insilico Medicine AI Limited, Abu Dhabi, UAE
  • Hong Kong Science and Technology Parks Corporation (HK)
  • Insilico Medicine Shanghai Ltd., Shanghai, China
  • Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
  • University of Toronto, Department of Chemistry and Department of Computer Science, Toronto, Canada
  • University of Chicago (US)
  • Insilico Medicine (United States) (US)
  • Insilico Medicine Canada Inc, Montreal, Quebec, Canada
Corresponding author
Zhavoronkov, Alex
Venue
bioRxiv (Cold Spring Harbor Laboratory)
Publisher
openRxiv
Published
2025-03-07
OpenAlex
W4408224138
Cited by
5
References
28
Citations by year
2026: 4 · 2025: 1
Type
posted content
Language
en
Open access
Locations
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Topics
  • Social Sciences › Arts and Humanities › History and Philosophy of Science › Academic Writing and Publishing
  • Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
  • Social Sciences › Decision Sciences › Information Systems and Management › Scientific Computing and Data Management
Keywords
multi-agent systems, AI research assistant, automated reporting, scientific exploration, large language models, generative AI, citation management, hypothesis generation, research workflow automation, DORA

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