Empowering biomedical discovery with AI agents
Open accessAbstract
We envision "AI scientists" as systems capable of skeptical learning and reasoning that empower biomedical research through collaborative agents that integrate AI models and biomedical tools with experimental platforms. Rather than taking humans out of the discovery process, biomedical AI agents combine human creativity and expertise with AI's ability to analyze large datasets, navigate hypothesis spaces, and execute repetitive tasks. AI agents are poised to be proficient in various tasks, planning discovery workflows and performing self-assessment to identify and mitigate gaps in their knowledge. These agents use large language models and generative models to feature structured memory for continual learning and use machine learning tools to incorporate scientific knowledge, biological principles, and theories. AI agents can impact areas ranging from virtual cell simulation, programmable control of phenotypes, and the design of cellular circuits to developing new therapies.
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Collaborative agent teams have produced superior results on complex bioinformatics analyses and clinical decision support challenges where no single model excels.
“collaborative agent teams have produced superior results on complex bioinformatics analyses and clinical decision support challenges where no single model excels [1,4].”
From A Review of Multi-Agent AI Systems for Biological and Clinical Data Analysis (2026) · cites this paper as [4]
In various domains, genomics, electronic health records, imaging, and beyond, MAS approaches have already demonstrated improved performance, reliability, and explainability compared to single-agent methods.
“In various domains, genomics, electronic health records, imaging, and beyond, MAS approaches have already demonstrated improved performance, reliability, and explainability compared to single-agent methods.”
From A Review of Multi-Agent AI Systems for Biological and Clinical Data Analysis (2026) · cites this paper as [4]
LLMs have the capability to use tools for automated online search, task design, and experiment execution.
“Furthermore, another critical feature of LLMs is their capability to use tools for automated online search, task design, and experiment execution [203–205], which exhibits their further capabilities in automatically collecting and preprocessing biomedical datasets, designing bioinformatic analyses to identify disease-related molecular regulations, conducting literature reviews for result inte”
From Challenges in AI-driven Biomedical Multimodal Data Fusion and Analysis (2025) · cites this paper as [205]
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Emerging technologies transforming the future of global biosecurity
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A Glossary of Terms in Artificial Intelligence for Healthcare
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Proceeding artificial intelligence technology towards vaccine designs
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Artificial Intelligence agents for biological research: a survey
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Epistemic responsibility: toward a community standard for human-AI collaborations
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- Authors
- Gao, S., Fang, A., Huang, Y., Giunchiglia, V., Noori, A., Schwarz, J. R., Ektefaie, Y., Kondic, J., & Zitnik, M.
- Affiliations
- Harvard University (US)
- Massachusetts Institute of Technology (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 187
- Issue
- 22
- Pages
- 6125-6151
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4403925918
- Cited by
- 315
- References
- 199
- Citations by year
- 2026: 168 · 2025: 135 · 2024: 12
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion, cc-by)
- arXiv (Cornell University) (cc-by)
- Funders
- Medical Research Council (T32 HG002295, MR/W00710X/1)
- National Institutes of Health (R01-HD108794)
- Harvard Medical School
- National Science Foundation (2339524, FA8702-15-D-0001)
- Aligning Science Across Parkinson's
- Harvard Data Science Initiative, Harvard University
- The Chan Zuckerberg Initiative
- National Human Genome Research Institute
- Milken Institute
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Social Sciences › Decision Sciences › Information Systems and Management › Scientific Computing and Data Management
- Keywords
- AI agents, AI scientists, biomedical discovery, large language models, generative models, continual learning, structured memory, hypothesis generation, therapy design, human-AI collaboration
- MeSH terms
- Machine Learning, Artificial Intelligence, Humans, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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