Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, Timothy R., Dufort, Connor, Dissing-Olesen, Lasse, Giera, Stefanie, Young, Adam, Wysoker, Alec, Walker, Alec J., Segel, Michael +7 more·2018·Immunity

DOI 10.1101/406140

Cited by (1,016)

Items 401–500 of 1,016

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis
Miguel Marin-Rodero, Elisa Cintado, Alec J. Walker, Teshika Jayewickreme, Felipe Almeida Pinho-Ribeiro, Quentin Richardson, Ruaidhrí P. Jackson, Isaac M. Chiu, Christophe O. Benoist, Beth Stevens et al. · 2025 · Science Immunology
Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS
Katherine D. LaClair, Qihui Zhou, Meike Michaelsen, Benedikt Wefers, Monika S. Brill, Aleksandar Janjic, Birgit Rathkolb, Daniel Farny, Mikolaj Cygan, Martin Hrabě de Angelis et al. · 2020 · Acta Neuropathologica
Shedding Light on the Dark Side of the Microglia
Marie‐Kim St‐Pierre, Eva Šimončičová, Eszter Bögi, Marie‐Ève Tremblay · 2020 · ASN NEURO
The CNS mononuclear phagocyte system in health and disease
Sarah Mundt, Melanie Greter, Burkhard Becher · 2022 · Neuron
Border-Associated Macrophages Transventricularly Infiltrate the Early Embryonic Cerebral Wall to Differentiate Into Microglia
Yuki Hattori, Daisuke Kato, Futoshi Murayama, Sota Koike, Hisa Asai, Ayato Yamasaki, Yu Naito, Ayano Kawaguchi, Hiroyuki Konishi, Marco Prinz et al. · 2022 · Cell Reports
Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents
Daniel Bormann, Michael Knoflach, Emilia Poreba, Christian J. Riedl, Giulia Testa, Cyrille Orset, Anthony Levilly, Andreá Cottereau, Philipp Jauk, Simon Hametner et al. · 2024 · Nature Communications
Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα
Tianwen Gao, Janna E. Jernigan, Syed Ali Raza, Eric B. Dammer, Hailian Xiao, Nicholas T. Seyfried, Allan I. Levey, Srikant Rangaraju · 2019 · Glia
Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations
Omkar L. Patkar, Melanie Caruso, Ngari Teakle, Sahar Keshvari, Stephen J. Bush, Clare Pridans, Arnauld Belmer, KIM M. SUMMERS, Katharine M. Irvine, David Arthur Hume · 2021 · Neurobiology of Disease
An update on the rod microglia variant in experimental and clinical brain injury and disease
Katherine R. Giordano, Charlotte R. Denman, Phoebe S Dubisch, Murtaza Akhter, Jonathan Lifshitz · 2021 · Brain Communications
White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
Rongjiao Shao, Dawei Sun, Yue Hu, Derong Cui · 2021 · Journal of Neuroscience Research
Unique Subtype of Microglia in Degenerative Thalamus After Cortical Stroke
Zhijuan Cao, Sean S. Harvey, Terrance Chiang, Aulden G. Foltz, Alex Gia Lee, Michelle Cheng, Gary Kenneth Steinberg · 2021 · Stroke
Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease
Kendra L. Hanslik, Kaitlyn M. Marino, Tyler Kent Ulland · 2021 · Frontiers in Cellular Neuroscience
Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage
GeorgeKwok Chu Wong, Junfan Chen, ZhiyuanVera Zheng, Gang Lü, Wai‐Yee Chan, Yisen Zhang · 2021 · Neural Regeneration Research
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
Miedema, Anneke, Gerrits, Emma, Brouwer, Nieske, Jiang, Qiong, Kracht, Laura, Meijer, Michel, Nutma, Erik, Peferoen-Baert, Regina, Pijnacker, Anna T. E., Wesseling, Evelyn M. et al. · 2022 · Acta Neuropathologica Communications
Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension
Qianqian Bi, Chao Wang, Guo Cheng, Ningting Chen, Bo Wei, Xiaoli Liu, Li Li, Cheng Chang Lu, Jian He, Yuancheng Weng et al. · 2022 · Immunity
Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease
Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Enrique Conde, Rodrigo Vinueza‐Gavilanes, Esther Luquin, África Vales, Amaya Vilas, Patxi San Martín‐Úriz, Ibón Tamayo et al. · 2022 · Glia
Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina
Kaira A. Church, Derek Rodriguez, Difernando Vanegas, Irene L. Gutiérrez, Sandra M. Cardona, José L. M. Madrigal, Tejbeer Kaur, Astrid E. Cardona · 2022 · Journal of Neuroinflammation
The Importance of Complement-Mediated Immune Signaling in Alzheimer’s Disease Pathogenesis
André F. Batista, Khyrul Khan, Maria-Tzousi Papavergi, Cynthia Ann Lemere · 2024 · International Journal of Molecular Sciences
An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination
Barclay, Kia M., Abduljawad, Nora, Cheng, Zuolin, Kim, Min Woo, Zhou, Lu, Yang, Jin, Rustenhoven, Justin, Mazzitelli, Jose A., Smyth, Leon C.D., Kapadia, Dvita et al. · 2024 · Immunity
MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome–like Behaviors in Mice
Adam J. Harrington, Catherine M. Bridges, Stefano Berto, Kayla Blankenship, Jennifer Y. Cho, Ahlem Assali, Benjamin M. Siemsen, Hannah Warren Moore, Evgeny Tsvetkov, Acadia M Thielking et al. · 2020 · Biological Psychiatry
Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain.
A. Osman, Ying Sun, Terry C. Burns, Li-Qun He, Nigel Kee, Nuria Oliva-Vilarnau, Androniki Alevyzaki, Kai Zhou, L. Louhivuori, P. Uhlén et al. · 2020 · Cell Reports
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans
Chloe Lopez-Lee, Lay Kodama, Li Gan · 2021 · Biological Psychiatry
Single Cell RNA-Seq Analysis Reveals Compartment-Specific Heterogeneity and Plasticity of Microglia
Junying Zheng, Wenjuan Ru, Jay R T. Adolacion, Michael S. Spurgat, Xin Liu, Subo Yuan, Rommel X. Liang, Jianli Dong, Andrew S. Potter, S. Steven Potter et al. · 2020 · iScience
NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss
Judith Stefanie Schlett, Melanie Mettang, Aladdin Skaf, Pavel Schweizer, Alina Errerd, Ephraim Alemayehu Mulugeta, Tabea Melissa Hein, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Ulrike F. G. Büttner et al. · 2023 · Molecular Neurodegeneration
Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions
Miguel Angel Abellanas, Marta Zamarbide, Leyre Basurco, Esther Luquin, Marta García‐Granero, Pedro Clavero, Patxi San Martín‐Úriz, Amaia Vilas‐Zornoza, Elisa Mengual, Sandra Hervás‐Stubbs et al. · 2019 · Journal of Neuroinflammation
Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice
David J. Reiss, Tando Maduna, Hervé Maurin, Emilie Audouard, Claire Gavériaux‐Ruff · 2020 · Journal of Neuroscience Research
MOG autoantibodies trigger a tightly-controlled FcR and BTK-driven microglia proliferative response
Kathryn Pellerin, Stephen J. Rubino, Jeremy Carlos Burns, Benjamin A Smith, Christie‐Ann McCarl, Jing Ke Zhu, Luke Jandreski, Patrick F. Cullen, Thomas M. Carlile, Angela Li et al. · 2021 · Brain
Microglia regulate chandelier cell axo-axonic synaptogenesis
Nicholas B. Gallo, Artan Berisha, Linda Van Aelst · 2022 · Proceedings of the National Academy of Sciences
Microglial responses to peripheral type 1 interferon
Ernest Aw, Yingying Zhang, Michael C. Carroll · 2020 · Journal of Neuroinflammation
In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain
Nicholas J. Silva, Leah C. Dorman, Ilia D. Vainchtein, Nadine C. Horneck, Anna Victoria Molofsky · 2021 · Nature Communications
Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell Technologies
Hansen Wang · 2021 · Frontiers in Synaptic Neuroscience
Profiling Microglia through Single-Cell RNA Sequencing over the Course of Development, Aging, and Disease
Spyros Pettas, Korina Karagianni, Ειrini Kanata, Athanasia Chatziefstathiou, Nikoletta Christoudia, Konstantinos Xanthopoulos, Theodoros Sklaviadis, Dimitra Dafou · 2022 · Cells
Reformulating Pro-Oxidant Microglia in Neurodegeneration
Juan García‐Revilla, Isabel María Alonso-Bellido, Miguel Ángel Burguillos, Antonio J. Herrera, Ana M. Espinosa‐Oliva, Rocío Ruiz, Luis Cruz-Hernández, Irene García-Domínguez, María Angustias Roca-Ceballos, Marti Santiago et al. · 2019 · Journal of Clinical Medicine
The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)
Barca, Cristina, Foray, Claudia, Hermann, Sven, Herrlinger, Ulrich, Remory, Isabel, Laoui, Damya, Schäfers, Michael, Grauer, Oliver M., Zinnhardt, Bastian, Jacobs, Andreas H. · 2021 · Frontiers in Immunology
Physiology of Microglia
Tuan Leng Tay, Micaël Carrier, Marie‐Ève Tremblay · 2019 · Advances in experimental medicine and biology
Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease
Ty D. Troutman, Eric R. Kofman, Christopher K. Glass · 2021 · Molecular Cell
Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence
Arjun Muralidharan, Susana G. Sotocinal, Noosha Yousefpour, Nur Akkurt, Laleska Brunelle Queiroz Lima, Shannon N. Tansley, Marc Parisien, Chengyang Wang, Jean‐Sebastien Austin, Boram Ham et al. · 2022 · Journal of Clinical Investigation
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
Tulsi Patel, Troy Carnwath, Xue Wang, Mariet Allen, Sarah Lincoln, Laura J. Lewis‐Tuffin, Zachary Quicksall, Shu Lin, Frederick Q Tutor‐New, Charlotte C.G. Ho et al. · 2022 · Aging Cell
Definition of the contribution of an Osteopontin-producing CD11c + microglial subset to Alzheimer’s disease
Yiguo Qiu, Xianli Shen, Orly Ravid, Dana Atrakchi, Daniel Rand, Andrew E. Wight, Hye-Jung Kim, Sigal Liraz Zaltsman, Itzik Cooper, Michal Schnaider Beeri et al. · 2023 · Proceedings of the National Academy of Sciences
Perinatal development of innate immune topology
Philipp Henneke, Katrin Kierdorf, Lindsay J Hall, Markus Sperandio, Mathias Walter Hornef · 2021 · eLife
Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease
Dhandapani, Rahul, Neri, Marilisa, Bernhard, Mario, Brzak, Irena, Schweizer, Tatjana, Rudin, Stefan, Joller, Stefanie, Berth, Ramon, Kernen, Jasmin, Neuhaus, Anna et al. · 2022 · Cell Reports
The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
Elliot J. Glotfelty, Luis B. Tovar‐y‐Romo, Shih‐Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig · 2023 · Cells
Immunotherapy-related cognitive impairment after CAR T cell therapy in mice
Anna C. Geraghty, Lehi Acosta-Alvarez, Maria Caterina Rotiroti, Selena Dutton, Michael R. O’Dea, Won‐Ju Kim, Vrunda Trivedi, Rebecca A. Mancusi, Kiarash Shamardani, Karen E. Malacon et al. · 2025 · Cell
Deciphering Brain Complexity using Single-Cell Sequencing
Quanhua Mu, Yiyun Chen, Jiguang Wang · 2019 · Genomics Proteomics & Bioinformatics
Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury
Batoul Ghaddar, Luisa Lübke, David Couret, Sepand Rastegar, Nicolas Diotel · 2021 · Cells
Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis
Jia Li, Congrui Zhao, Yangbo Xu, Lu Song, Yanqi Chen, Yuzi Xu, Yang Ma, Siyuan Wang, Antian Xu, Fuming He · 2022 · Bioactive Materials
Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis
Katrina T. Evans, Kerrigan Blake, Aaron J. Longworth, Morgan Coburn, Jacob Insua‐Rodríguez, Timothy P McMullen, Quy Nguyen, Dennis Ma, Tatyana Lev, Grace A. Hernandez et al. · 2023 · Nature Cell Biology
Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration
Liansheng Zhang, Zhengzheng Xu, Zhiheng Jia, Shicheng Cai, Qiang Wu, Xingyu Liu, Xinde Hu, Tao Bai, Yongyu Chen, Tianwen Li et al. · 2025 · Nature Aging
Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis
Stefano Pluchino, Jayden A. Smith, Luca Peruzzotti‐Jametti · 2020 · Trends in Molecular Medicine
Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities
Junxuan Lyu, Xiaoyan Jiang, Rehana K. Leak, Yejie Shi, Xiaoming Hu, Jun Chen · 2020 · Translational Stroke Research
Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis
Böttcher, Chotima, van der Poel, Marlijn, Fernández-Zapata, Camila, Schlickeiser, Stephan, Leman, Julia K. H., Hsiao, Cheng-Chih, Mizee, Mark R., Adelia, Vincenten, Maria C. J., Kunkel, Desiree et al. · 2020 · Acta Neuropathologica Communications
Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging
Nicholas R W Cleland, Saif I. Al‐Juboori, Evgenia Dobrinskikh, Kimberley D. Bruce · 2021 · Journal of Neuroinflammation
Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain
Shen, Xianli, Qiu, Yiguo, Wight, Andrew E., Kim, Hye-Jung, Cantor, Harvey · 2022 · Proceedings of the National Academy of Sciences
Roles of multiple lipid mediators in stress and depression
Tomoyuki Furuyashiki, Satoshi Akiyama, Shiho Kitaoka · 2019 · International Immunology
Exercise prevents obesity-induced cognitive decline and white matter damage in mice
Leah C. Graham, Weronika A. Grabowska, Yoona Chun, Shannon L. Risacher, Vivek M. Philip, Andrew J. Saykin, Stacey J. Sukoff Rizzo, Gareth R. Howell · 2019 · Neurobiology of Aging
A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors
Jessica M. Rosin, Sarthak Sinha, Jeff A. Biernaskie, Deborah Marie Kurrasch · 2021 · Developmental Cell
Arresting the bad seed: HDAC3 regulates proliferation of different microglia after ischemic stroke
Zhang, Yue, Li, Jiaying, Zhao, Yongfang, Huang, Yichen, Shi, Ziyu, Wang, Hailian, Cao, Hui, Wang, Chenran, Wang, Yana, Chen, Di et al. · 2024 · Science Advances
Glial Cells Promote Myelin Formation and Elimination
Alexandria Hughes · 2021 · Frontiers in Cell and Developmental Biology
Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence
Sarah R Anderson, Jacqueline M. Roberts, Nate Ghena, Emmalyn Irvin, Joon Schwakopf, Isabelle B. Cooperstein, Alejandra Bosco, Monica L Vetter · 2022 · eLife
Signaling pathways in brain ischemia: Mechanisms and therapeutic implications
Wen Lin, Xiaosu Zhao, Jiawen Cheng, Litao Li, Quan Jiang, Yixuan Zhang, Feng Han · 2023 · Pharmacology & Therapeutics
The ins and outs of microglial cells in brain health and disease
Carla Pallarés-Moratalla, Gabriele Bergers · 2024 · Frontiers in Immunology
Development of a High-Throughput Pipeline to Characterize Microglia Morphological States at a Single-Cell Resolution
Jennifer S. Kim, Paul Pavlidis, Annie Vogel Ciernia · 2024 · eNeuro
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
Vini Tiwari, Bharat Prajapati, Yaw Asare, Alkmini Damkou, Hao Ji, Lu Liu, Nawraa Naser, Garyfallia Gouna, Katarzyna B. Leszczyńska, Jakub Mieczkowski et al. · 2024 · Immunity
Understanding microglial diversity and implications for neuronal function in health and disease
Sebastiaan De Schepper, Gerard Crowley, Soyon Youngae Hong · 2020 · Developmental Neurobiology
Tools and Approaches for Studying Microglia In vivo
Elisa Eme‐Scolan, Samantha J. Dando · 2020 · Frontiers in Immunology
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice
Cheng‐Hao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi · 2021 · Aging and Disease
Microglia in Health and Disease: The Strength to Be Diverse and Reactive
Oihane Uriarte Huarte, Lorraine Richart, Michel Guy André Mittelbronn, Alessandro Michelucci · 2021 · Frontiers in Cellular Neuroscience
The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation
Hainan Lang, Kenyaria V. Noble, Jeremy L. Barth, Jeffrey A. Rumschlag, Tyreek R. Jenkins, Shelby Storm, Mark A. Eckert, Judy R. Dubno, Bradley A. Schulte · 2023 · Journal of Neuroscience
The roles of tissue resident macrophages in health and cancer
Minmin Cao, Zihao Wang, Wanying Lan, Binghua Xiang, Wenjun Liao, Jie Zhou, Xiaomeng Liu, Yiling Wang, Shichuan Zhang, Shun Lu et al. · 2024 · Experimental Hematology and Oncology
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations
Cadiz, Mika P., Gibson, Katelin A., Todd, Kennedi T., Nascari, David G., Massa, Nashali, Lilley, Meredith T., Olney, Kimberly C., Al-Amin, Md Mamun, Jiang, Hong, Holtzman, David M. et al. · 2024 · Journal of Experimental Medicine
Microglial innate memory and epigenetic reprogramming in neurological disorders
Ricardo Martins-Ferreira, Bárbara Leal, Paulo Costa, Esteban Ballestar · 2020 · Progress in Neurobiology
Colony stimulating factors in the nervous system
Violeta Chiţu, Fabrizio Biundo, E. Richard Stanley · 2021 · Seminars in Immunology
Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes
Weizhuo Lu, Jiyue Wen · 2024 · Aging and Disease
IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs
Saeki, Keita, Pan, Richard, Lee, Eunju, Kurotaki, Daisuke, Ozato, Keiko · 2024 · Nature Immunology
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution
Joshua S. Schiffman, Andrew R. D’Avino, Tamara Prieto, Yakun Pang, Yilin Fan, Srinivas Rajagopalan, Catherine J. Potenski, Toshiro Hara, Mario L. Suvà, Charles Gawad et al. · 2024 · Nature Genetics
Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries
Eleftherios I. Paschalis, Fengyang Lei, Chengxin Zhou, Xiaohong Nancy Chen, Vassiliki Kapoulea, Pui‐Chuen Hui, Reza Dana, James Chodosh, Demetrios G. Vavvas, Claes Henrik Dohlman · 2018 · The Journal of Immunology
Regulation of microglia population dynamics throughout development, health, and disease
Brady P. Hammond, Rupali Manek, Bradley J. Kerr, Matthew Scott Macauley, Jason R. Plemel · 2021 · Glia
Microglia and Microglia-Like Cells: Similar but Different
Miguel Ángel Cuadros, M. Rosario Sepúlveda, David Martín‐Oliva, José L. Marín‐Teva, Veronika E. Neubrand · 2022 · Frontiers in Cellular Neuroscience
Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
Zhiping Liu, Huidong Shi, Jiean Xu, Qiuhua Yang, Qian Ma, Xiaoxiao Mao, Zhimin Xu, Yaqi Zhou, Qingen Da, Yongfeng Cai et al. · 2022 · JCI Insight
Lipid metabolism in microglia: Emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review)
Yunlong Sun, Kaifang Wei, Xudong Liao, Jianan Wang, Lina Gao, Bo Pang · 2025 · International Journal of Molecular Medicine
Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana K. Prasad, Fabian Köchl, Marcel Leist et al. · 2021 · Frontiers in Immunology
Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan
Irene F. Ugidos, Cristiana Pistono, Paula Korhonen, Mireia Gómez‐Budia, Valeriia Sitnikova, Pamela Klecki, Iveta Stanová, Jukka Jolkkonen, Tarja Malm · 2022 · Stroke
Microglia colonize the developing brain by clonal expansion of highly proliferative progenitors, following allometric scaling
Liam Barry-Carroll, Philip Greulich, Abigail R. Marshall, Kristoffer Riecken, Boris Fehse, Katharine E. Askew, Kaizhen Li, Olga Garaschuk, David A. Menassa, Diego Gómez‐Nicola · 2023 · Cell Reports
Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases
Francisco Javier Rodríguez‐Baena, Ángel Márquez-Galera, Pablo Ballesteros-Martinez, Alba Castillo, Eva Diaz, Gema Moreno‐Bueno, José P. López‐Atalaya, Berta L. Sánchez‐Laorden · 2025 · Cancer Cell
Persistent accumulation of therapy-induced senescent cells: an obstacle to long-term cancer treatment efficacy
Jingjing Luo, Tongxu Sun, Zhenghui Liu, Yangfan Liu, Junjiang Liu, Shimeng Wang, Xueke Shi, Hongmei Zhou · 2025 · International Journal of Oral Science
Dynamic fibroblast–immune interactions shape recovery after brain injury
Nathan A. Ewing-Crystal, Nicholas M. Mroz, Amara Larpthaveesarp, Carlos O. Lizama, Remy Pennington, Pailin Chiaranunt, Jason I. Dennis, Anthony A. Chang, Eric Dean Merrill, Sofia E. Caryotakis et al. · 2025 · Nature
Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis
Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Yun Peng et al. · 2020 · Brain Behavior and Immunity
The Application of Single-Cell RNA Sequencing in Studies of Autoimmune Diseases: a Comprehensive Review
Mingming Zhao, Jiao Jiang, Ming Zhao, Christopher Chang, Haijing Wu, Qianjin Lu · 2020 · Clinical Reviews in Allergy & Immunology
Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Christopher A Alvarez-Breckenridge, Samuel C. Markson, Jackson H. Stocking, Naema Nayyar, Matt Lastrapes, Matthew R. Strickland, Albert Eusik Kim, Magali A. de Sauvage, Ashish Dahal, Juliana M. Larson et al. · 2022 · Cancer Immunology Research
Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system
Grace Hammel, Sandra Zivkovic, Maryam Ayazi, Yi Ren · 2022 · Cellular Immunology
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy
Pan, Li, Cho, Kin-Sang, Wei, Xin, Xu, Fuyi, Lennikov, Anton, Hu, Guangan, Tang, Jing, Guo, Shuai, Chen, Julie, Kriukov, Emil et al. · 2023 · Cell Reports
Single-Cell Analysis of Neuroinflammatory Responses Following Intracranial Injection of G-Deleted Rabies Viruses
Kee Wui Huang, Bernardo Luis Sabatini · 2020 · Frontiers in Cellular Neuroscience
Microglial ontogeny, diversity and neurodevelopmental functions
Morgane Sonia Thion, Sonia Garel · 2020 · Current Opinion in Genetics & Development
Multifaceted microglia — key players in primary brain tumour heterogeneity
Lily Keane, Mathilde Cheray, Klas Blomgren, Bertrand Joseph · 2021 · Nature Reviews Neurology
Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
Uriarte Huarte, Oihane, Kyriakis, Dimitrios, Heurtaux, Tony, Pires-Afonso, Yolanda, Grzyb, Kamil, Halder, Rashi, Buttini, Manuel, Skupin, Alexander, Mittelbronn, Michel, Michelucci, Alessandro · 2021 · Frontiers in Immunology
A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
Angela Oliveira Pisco, Aaron McGeever, Nicholas Schaum, Jim Karkanias, Norma F Neff, Spyros Darmanis, Tony Wyss‐Coray, Stephen R. Quake · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke
Hernandez, Victoria G., Lechtenberg, Kendra J., Peterson, Todd C., Zhu, Li, Lucas, Tawaun A., Bradshaw, Karen P., Owah, Justice O., Dorsey, Alanna I., Gentles, Andrew J., Buckwalter, Marion S. · 2023 · Glia
Age-dependent immune and lymphatic responses after spinal cord injury
Andrea Francesca Salvador, Taitea Dykstra, Justin Rustenhoven, Wenqing Gao, Susan M. Blackburn, Kesshni Bhasiin, Michael Q. Dong, Rafaela Mano Guimarães, Sriharsha Gonuguntla, Igor Smirnov et al. · 2023 · Neuron
Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer
K. Hu, Nicholas F. Kuhn, Tristan Courau, Jessica L. Tsui, B. Samad, Patrick K. Ha, J. Kratz, A. Combes, M. Krummel · 2023 · Cell Stem Cell
Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential
Justin You, Mohieldin Youssef, Jhune Rizsan Santos, Jooyun Lee, Jeehye Park · 2023 · Biology