Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, Timothy R., Dufort, Connor, Dissing-Olesen, Lasse, Giera, Stefanie, Young, Adam, Wysoker, Alec, Walker, Alec J., Segel, Michael +7 more·2018·Immunity

Cited by (1,016)

Items 101–200 of 1,016

  1. Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects
    Feringa, Femke M., van der Kant, Rik · 2021 · Frontiers in Aging Neuroscience
  2. Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?
    Liddelow, Shane A., Marsh, Samuel E., Stevens, Beth · 2020 · Trends in Immunology
  3. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging
    Kaya, Tuğberk, Mattugini, Nicola, Liu, Lu, Ji, Hao, Cantuti-Castelvetri, Ludovico, Wu, Jianping, Schifferer, Martina, Groh, Janos, Martini, Rudolf, Besson-Girard, Simon et al. · 2022 · Nature Neuroscience
  4. Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease
    Lewcock, Joseph W., Schlepckow, Kai, Di Paolo, Gilbert, Tahirovic, Sabina, Monroe, Kathryn M., Haass, Christian · 2020 · Neuron
  5. A cellular taxonomy of the adult human spinal cord
    Archana Yadav, Kaya J.E. Matson, Li Li, Isabelle Hua, Joana Petrescu, Kristy Kang, Mor R. Alkaslasi, Dylan I. Lee, Saadia Hasan, Ahmad Galuta et al. · 2023 · Neuron
  6. Stroke subtype-dependent synapse elimination by reactive gliosis in mice
    Xiaojing Shi, Longlong Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Heng‐Li Tian et al. · 2021 · Nature Communications
  7. Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts
    Jun Qin, Zhihui Ma, Xiaoli Chen, Shiyu Shu · 2023 · Frontiers in Neurology
  8. Human fetal microglia acquire homeostatic immune-sensing properties early in development
    Laura Kracht, Malte Borggrewe, Sharon Eskandar, Nieske Brouwer, Susana M. Chuva de Sousa Lopes, Jon D. Laman, Sicco A. Scherjon, Jelmer Riemer Prins, Susanne M. Kooistra, Bart J. L. Eggen · 2020 · Science
  9. <i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
    Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A et al. · 2020 · Human Molecular Genetics
  10. Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
    Bernier, Louis-Philippe, Bohlen, Christopher J., York, Elisa M., Choi, Hyun B., Kamyabi, Alireza, Dissing-Olesen, Lasse, Hefendehl, Jasmin K., Collins, Hannah Y., Stevens, Beth, Barres, Ben A. et al. · 2019 · Cell Reports
  11. Glial and myeloid heterogeneity in the brain tumour microenvironment
    Brian M. Andersen, Camilo Faust Akl, Michael A. Wheeler, Ennio Antonio Chiocca, David A. Reardon, Francisco Javier Quintana · 2021 · Nature reviews. Cancer
  12. Transcriptional and epigenetic decoding of the microglial aging process
    Xiaoyu Li, Yuxin Li, Yuxiao Jin, Yuheng Zhang, Jingchuan Wu, Zhen Xu, Yubin Huang, Lin Cai, Shuai Gao, Taohui Liu et al. · 2023 · Nature Aging
  13. Inflammation: A Target for Treatment in Spinal Cord Injury
    Ximena Freyermuth-Trujillo, Julia J. Segura-Uribe, Hermelinda Salgado‐Ceballos, Carlos Enrique Orozco-Barrios, Angélica Coyoy-Salgado · 2022 · Cells
  14. Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
    Yun Li, Xiaohuan Xia, Yi Wang, Jialin Zheng · 2022 · Journal of Neuroinflammation
  15. Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
    Lidia García‐Bonilla, Ziasmin Shahanoor, Rose K. Sciortino, Omina Nazarzoda, Gianfranco Racchumi, Costantino Iadecola, Josef Anrather · 2024 · Nature Immunology
  16. Early Alzheimer’s disease pathology in human cortex involves transient cell states
    Gazestani, Vahid, Kamath, Tushar, Nadaf, Naeem M., Dougalis, Antonios, Burris, S.J., Rooney, Brendan, Junkkari, Antti, Vanderburg, Charles, Pelkonen, Anssi, Gomez-Budia, Mireia et al. · 2023 · Cell
  17. Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
    Plemel, Jason R., Stratton, Jo Anne, Michaels, Nathan J., Rawji, Khalil S., Zhang, Eric, Sinha, Sarthak, Baaklini, Charbel S., Dong, Yifei, Ho, Madelene, Thorburn, Kevin et al. · 2020 · Science Advances
  18. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation
    Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean et al. · 2020 · Nature Immunology
  19. The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation
    Ashley L. Comer, Micaël Carrier, Marie‐Ève Tremblay, Alberto Cruz‐Martín · 2020 · Frontiers in Cellular Neuroscience
  20. Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
    Choi, Insup, Wang, Minghui, Yoo, Seungyeul, Xu, Peng, Seegobin, Steven P., Li, Xianting, Han, Xian, Wang, Qian, Peng, Junmin, Zhang, Bin et al. · 2023 · Nature Cell Biology
  21. Single-cell analyses of aging, inflammation and senescence
    Bora Uyar, Daniel H. Palmer, Axel Kowald, Hugo Murua Escobar, Israel Barrantes, Steffen Möller, Altuna Akalin, Georg Fuellen · 2020 · Ageing Research Reviews
  22. Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21
    Abels, Erik R., Maas, Sybren L.N., Nieland, Lisa, Wei, Zhiyun, Cheah, Pike See, Tai, Eric, Kolsteeg, Christy-Joy, Dusoswa, Sophie A., Ting, David T., Hickman, Suzanne et al. · 2019 · Cell Reports
  23. Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease
    Guillot-Sestier, Marie-Victoire, Araiz, Ana Rubio, Mela, Virginia, Gaban, Aline Sayd, O’Neill, Eoin, Joshi, Lisha, Chouchani, Edward T., Mills, Evanna L., Lynch, Marina A. · 2021 · Communications Biology
  24. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
    Jiasheng Zhang, Dmitry Velmeshev, Kei Hashimoto, Yu‐Hsin Huang, Jeffrey W. Hofmann, Xiaoyu Shi, Jiapei Chen, Andrew M. Leidal, Julian G. Dishart, Michelle K. Cahill et al. · 2020 · Nature
  25. TREM2 dependent and independent functions of microglia in Alzheimer’s disease
    Hou, Jinchao, Chen, Yun, Grajales-Reyes, Gary, Colonna, Marco · 2022 · Molecular Neurodegeneration
  26. Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
    Bruna Araújo, Rita Caridade-Silva, Carla Soares-Guedes, Joana Martins‐Macedo, Eduardo D. Gomes, Susana Monteiro, Fábio Gabriel Teixeira · 2022 · Cells
  27. Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions
    Élisabeth Traiffort, Abdelmoumen Kassoussi, Amina Zahaf, Yousra Laouarem · 2020 · Frontiers in Cellular Neuroscience
  28. Circulating myeloid-derived MMP8 in stress susceptibility and depression
    Cathomas, Flurin, Lin, Hsiao-Yun, Chan, Kenny L., Li, Long, Parise, Lyonna F., Alvarez, Johana, Durand-de Cuttoli, Romain, Aubry, Antonio V., Muhareb, Samer, Desland, Fiona et al. · 2024 · Nature
  29. Microglia as Dynamic Cellular Mediators of Brain Function
    Elizabeth C. Wright-Jin, David H. Gutmann · 2019 · Trends in Molecular Medicine
  30. Microglia regulation of central nervous system myelin health and regeneration
    Kent, Sarah A., Miron, Veronique E. · 2024 · Nature Reviews Immunology
  31. Type-I-interferon-responsive microglia shape cortical development and behavior
    Escoubas, Caroline C., Dorman, Leah C., Nguyen, Phi T., Lagares-Linares, Christian, Nakajo, Haruna, Anderson, Sarah R., Barron, Jerika J., Wade, Sarah D., Cuevas, Beatriz, Vainchtein, Ilia D. et al. · 2024 · Cell
  32. Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
    Astrid De Boeck, Bo Young Ahn, Charlotte D’Mello, Xueqing Q. Lun, Shyam V. Menon, Mana M. Alshehri, Frank Szulzewsky, Yaoqing Shen, Lubaba Khan, Ngoc Ha Dang et al. · 2020 · Nature Communications
  33. Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia
    Dong, Yifei, D’Mello, Charlotte, Pinsky, William, Lozinski, Brian M., Kaushik, Deepak K., Ghorbani, Samira, Moezzi, Dorsa, Brown, Dennis, Melo, Francisca C., Zandee, Stephanie et al. · 2021 · Nature Neuroscience
  34. Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes
    Zhongshan Shi, Pei Yu, Wei‐Jye Lin, Sitai Chen, Xia Hu, Siqi Chen, Jinping Cheng, Qiang Liu, Yuhua Yang, Shaojian Li et al. · 2023 · Neuron
  35. Glioblastoma heterogeneity at single cell resolution
    David Eisenbarth, Yanru Wang · 2023 · Oncogene
  36. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain
    Shannon N. Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown et al. · 2022 · Nature Communications
  37. A new genetic strategy for targeting microglia in development and disease
    McKinsey, Gabriel L, Lizama, Carlos O, Keown-Lang, Amber E, Niu, Abraham, Santander, Nicolas, Larpthaveesarp, Amara, Chee, Elin, Gonzalez, Fernando F, Arnold, Thomas D · 2020 · eLife
  38. Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma
    Verena Claudia Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Pérez-Hernández, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent J. Magrini, Amy Ly, Jason Walker et al. · 2019 · Acta Neuropathologica Communications
  39. Microglia as hackers of the matrix: sculpting synapses and the extracellular space
    Crapser, Joshua D., Arreola, Miguel A., Tsourmas, Kate I., Green, Kim N. · 2021 · Cellular &amp; Molecular Immunology
  40. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
    Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy et al. · 2023 · Nature Immunology
  41. CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
    Franklin, Robin J.M., Simons, Mikael · 2022 · Neuron
  42. Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
    Danyang He, Heping Xu, Huiyuan Zhang, Ruihan Tang, Yangning Lan, Ruxiao Xing, Shaomin Li, Elena Christian, Yu Hou, Paul J. Lorello et al. · 2022 · Immunity
  43. Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation
    Joachim Ludwig Schultze, Elvira Mass, Andreas Schlitzer · 2019 · Immunity
  44. Microglia versus Monocytes: Distinct Roles in Degenerative Diseases of the Retina
    Yu Chen, Christophe Roubeix, Florian Sennlaub, Daniel R. Saban · 2020 · Trends in Neurosciences
  45. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10
    Ian Hunter Guldner, Qingfei Wang, Lin Yang, Samantha M. Golomb, Zhuo Zhao, Jacqueline A. Lopez, Abigail Brunory, Erin N. Howe, Yizhe Zhang, Bhavana Palakurthi et al. · 2020 · Cell
  46. Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
    Karen De Vlaminck, Hannah Van Hove, Daliya Kancheva, Isabelle Scheyltjens, Ana Rita Pombo Antunes, Jonathan Bastos, Mónica Vara‐Pérez, Leen Ali, Myrthe Mampay, Lauren Deneyer et al. · 2021 · Immunity
  47. The microglial component of amyotrophic lateral sclerosis
    Clarke, Benjamin E, Patani, Rickie · 2020 · Brain
  48. Olfactory sensory experience regulates gliomagenesis via neuronal IGF1
    Pengxiang Chen, Wei Wang, Rui Liu, Jiahui Lyu, Lei Zhang, Baizhou Li, Biying Qiu, Anhao Tian, Wenhong Jiang, Honggang Ying et al. · 2022 · Nature
  49. Microglia and lipids: how metabolism controls brain innate immunity
    Chausse, Bruno, Kakimoto, Pamela A., Kann, Oliver · 2021 · Seminars in Cell &amp; Developmental Biology
  50. When encephalitogenic T cells collaborate with microglia in multiple sclerosis
    Yifei Dong, Voon Wee Yong · 2019 · Nature Reviews Neurology
  51. The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis
    Monokesh Kumer Sen, David Anthony Mahns, Jens R. Coorssen, Peter John Shortland · 2022 · Glia
  52. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
    Schonhoff, A. M., Figge, D. A., Williams, G. P., Jurkuvenaite, A., Gallups, N. J., Childers, G. M., Webster, J. M., Standaert, D. G., Goldman, J. E., Harms, A. S. · 2023 · Nature Communications
  53. CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia
    Zhongsheng Hu, Nan Deng, Kai‐Li Liu, Nan Zhou, Yue Sun, Wenwen Zeng · 2020 · Cell Reports
  54. Astrocytes and microglia: Models and tools
    Kevin A. Guttenplan, Shane Antony Liddelow · 2018 · The Journal of Experimental Medicine
  55. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
    García-Revilla, Juan, Boza-Serrano, Antonio, Espinosa-Oliva, Ana M., Soto, Manuel Sarmiento, Deierborg, Tomas, Ruiz, Rocío, de Pablos, Rocío M., Burguillos, Miguel Angel, Venero, Jose L. · 2022 · Cell Death &amp; Disease
  56. MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
    Ioanna Plastira, Eva Maria Bernhart, Lisha Joshi, Chintan N. Koyani, Heimo M. Strohmaier, Helga Reicher, Ernst Malle, Wolfgang Sattler · 2020 · Journal of Neuroinflammation
  57. Microglia-mediated neuroinflammation and neuroplasticity after stroke
    Yuan Wang, Rehana K. Leak, Guodong Cao · 2022 · Frontiers in Cellular Neuroscience
  58. Defining the age-dependent and tissue-specific circadian transcriptome in male mice
    Christopher A. Wolff, Miguel A. Gutierrez‐Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann T. Pham, Aline Cristina da Silva Oliveira et al. · 2023 · Cell Reports
  59. A common framework of monocyte-derived macrophage activation
    David E. Sanin, Yan Ge, Emilija Marinković, Agnieszka Martyna Kabat, Ângela Castoldi, George Caputa, Katarzyna M. Grzes, Jonathan D. Curtis, Elizabeth A. Thompson, Sebastian Willenborg et al. · 2022 · Science Immunology
  60. Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases
    Anika Wu, Daehoon Lee, Wen‐Cheng Xiong · 2023 · International Journal of Molecular Sciences
  61. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation
    Chu, Erskine, Mychasiuk, Richelle, Hibbs, Margaret L., Semple, Bridgette D. · 2021 · Journal of Neuroinflammation
  62. Beyond the gut: decoding the gut–immune–brain axis in health and disease
    Park, John Chulhoon, Chang, Leechung, Kwon, Ho-Keun, Im, Sin-Hyeog · 2025 · Cellular &amp; Molecular Immunology
  63. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
    Sebastian Monasor, Laura, Müller, Stephan A, Colombo, Alessio Vittorio, Tanrioever, Gaye, König, Jasmin, Roth, Stefan, Liesz, Arthur, Berghofer, Anna, Piechotta, Anke, Prestel, Matthias et al. · 2020 · eLife
  64. Insights into Alzheimer’s disease from single-cell genomic approaches
    Murdock, Mitchell H., Tsai, Li-Huei · 2023 · Nature Neuroscience
  65. Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression
    Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini, Cristiano Machado Galhardi, Cláudia Rucco Penteado Detregiachi, Luíza Santos de Argollo Haber, Domingos Donizeti Roque, Marcelo Dib Bechara, Marcela Vialogo Marques de Castro et al. · 2024 · Frontiers in Immunology
  66. Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine
    Lynch, Marina A. · 2022 · Frontiers in Aging Neuroscience
  67. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
    Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana et al. · 2021 · Neuron
  68. What Do Microglia Really Do in Healthy Adult Brain?
    Marcus Augusto‐Oliveira, Gabriela de Paula Arrifano, Amanda Lopes-Araújo, Letícia Santos-Sacramento, Priscila Yuki Takeda, Daniel C. Anthony, João Oliveira Malva, Maria Elena Crespo Lopez · 2019 · Cells
  69. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
    Maes, Margaret E., Colombo, Gloria, Schulz, Rouven, Siegert, Sandra · 2019 · Neuroscience Letters
  70. Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
    Emily Kamma, Wendy O Lasisi, Cole D. Libner, Huah Shin Ng, Jason R. Plemel · 2022 · Journal of Neuroinflammation
  71. Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
    Jessica L. Bolton, Annabel K. Short, Shivashankar Othy, Cassandra L. Kooiker, Manlin Shao, Benjamin G. Gunn, Jaclyn Beck, Xinglong Bai, Stephanie M. Law, Julie C. Savage et al. · 2022 · Cell Reports
  72. Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain
    Han, Bing, Zhou, Shunheng, Zhang, Yuan, Chen, Sina, Xi, Wen, Liu, Chenchen, Zhou, Xu, Yuan, Mengqin, Yu, Xiaoyu, Li, Lu et al. · 2024 · Science Translational Medicine
  73. Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
    Shuo Chen, Yuzhou Chang, Liangping Li, Diana M. Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody T. Morrison, Dominic L. Julian et al. · 2022 · Acta Neuropathologica Communications
  74. Neoplastic and Immune Single Cell Transcriptomics Define Subgroup-Specific Intra-Tumoral Heterogeneity of Childhood Medulloblastoma
    Kent A. Riemondy, Sujatha Venkataraman, Nicholas Willard, Anandani Nellan, Bridget L. Sanford, Andrea M. Griesinger, Vladimir M. Amani, Siddhartha S. Mitra, Todd Cameron Hankinson, Michael H. Handler et al. · 2020 · Neuro-Oncology
  75. Transcriptional profiling of microglia; current state of the art and future perspectives
    Gerrits, Emma, Heng, Yang, Boddeke, Erik W. G. M., Eggen, Bart J. L. · 2020 · Glia
  76. Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke
    Chen, Hong-Ru, Sun, Yu-Yo, Chen, Ching-Wen, Kuo, Yi-Min, Kuan, Irena S., Tiger Li, Zheng-Rong, Short-Miller, Jonah C., Smucker, Marchelle R., Kuan, Chia-Yi · 2020 · Science Advances
  77. The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke
    Sinai Kim, Wonhyo Lee, Huiju Jo, Seongkeun Sonn, Se‐Jin Jeong, Seungwoon Seo, Joowon Suh, Jing Jin, Hyae Yon Kweon, Tae Kyeong Kim et al. · 2022 · Redox Biology
  78. The choroid plexus: a missing link in our understanding of brain development and function
    Norman Ruthven Saunders, Katarzyna M. Dzięgielewska, Ryann M. Fame, Maria K. Lehtinen, Shane Antony Liddelow · 2022 · Physiological Reviews
  79. Protective Microglial Subset in Development, Aging, and Disease: Lessons From Transcriptomic Studies
    Anouk Benmamar‐Badel, Trevor Owens, Agnieszka Włodarczyk · 2020 · Frontiers in Immunology
  80. TNF Production and Release from Microglia via Extracellular Vesicles: Impact on Brain Functions
    Stefano Raffaele, Marta Lombardi, Claudia Verderio, Marta Fumagalli · 2020 · Cells
  81. Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress
    Rysa Zaman, Homaira Hamidzada, Crystal Kantores, Anthony Wong, Sarah A. Dick, Yiming Wang, Abdul Momen, Laura Aronoff, Julia Lin, Babak Razani et al. · 2021 · Immunity
  82. Brain macrophage development, diversity and dysregulation in health and disease
    Silvin, Aymeric, Qian, Jiawen, Ginhoux, Florent · 2023 · Cellular &amp; Molecular Immunology
  83. Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
    Kelly Jin, Zizhen Yao, Cindy T. J. van Velthoven, Eitan S Kaplan, Katie J. Glattfelder, Samuel T. Barlow, Gabriella Boyer, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka et al. · 2025 · Nature
  84. The immune system and psychiatric disease: a basic science perspective
    F. Chris Bennett, Anna Victoria Molofsky · 2019 · Clinical & Experimental Immunology
  85. Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation
    DePaula-Silva, Ana Beatriz, Gorbea, Carlos, Doty, Daniel J., Libbey, Jane E., Sanchez, John Michael S., Hanak, Tyler J., Cazalla, Demián, Fujinami, Robert S. · 2019 · Journal of Neuroinflammation
  86. Role of microglia in stroke
    Anna Maria Planas · 2024 · Glia
  87. An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
    Millet, Alon, Ledo, Jose Henrique, Tavazoie, Sohail F. · 2024 · Immunity
  88. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation
    Cui, Jin, Shipley, Frederick B., Shannon, Morgan L., Alturkistani, Osama, Dani, Neil, Webb, Mya D., Sugden, Arthur U., Andermann, Mark L., Lehtinen, Maria K. · 2020 · Developmental Cell
  89. Single-cell omics in ageing: a young and growing field
    Xiaojuan He, Sebastian Memczak, Jing Tao Qu, Juan Carlos Izpisúa Belmonte, Guang‐Hui Liu · 2020 · Nature Metabolism
  90. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
    Fitz, Nicholas F., Nam, Kyong Nyon, Wolfe, Cody M., Letronne, Florent, Playso, Brittany E., Iordanova, Bistra E., Kozai, Takashi D. Y., Biedrzycki, Richard J., Kagan, Valerian E., Tyurina, Yulia Y. et al. · 2021 · Nature Communications
  91. Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
    Raquel Maria Sanchez-Varo, Marina Mejias‐Ortega, Juan José Fernandez-Valenzuela, Cristina Nuñez‐Diaz, Laura Cáceres-Palomo, Laura Vegas‐Gomez, Elisabeth Sánchez‐Mejías, Laura Trujillo‐Estrada, Juan Antonio García‐León, Inés Moreno‐González et al. · 2022 · International Journal of Molecular Sciences
  92. Molecular and metabolic heterogeneity of astrocytes and microglia
    Philip Hasel, William H. Aisenberg, F. Chris Bennett, Shane Antony Liddelow · 2023 · Cell Metabolism
  93. The Evolving Concept of the Blood Brain Barrier (BBB): From a Single Static Barrier to a Heterogeneous and Dynamic Relay Center
    A.F. Villabona-Rueda, Clara Erice, Carlos A. Pardo, Monique F. Stins · 2019 · Frontiers in Cellular Neuroscience
  94. The influence of environment and origin on brain resident macrophages and implications for therapy
    Mariko L. Bennett, F. Chris Bennett · 2019 · Nature Neuroscience
  95. Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors
    Bordt, Evan A., Ceasrine, Alexis M., Bilbo, Staci D. · 2020 · Glia
  96. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers
    Anna S. Warden, Sarah A. Wolfe, Sophia Khom, Florence P. Varodayan, Reesha R. Patel, Michael Q. Steinman, Michal Bajo, Sarah E. Montgomery, Roman Vlkolinský, Tali Nadav et al. · 2020 · Biological Psychiatry
  97. Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
    Carolin Beuker, David Schafflick, Jan‐Kolja Strecker, Michael Heming, Xiaolin Li, Jolien Wolbert, Antje Schmidt‐Pogoda, Christian Thomas, Tanja Kuhlmann, Irene Aranda-Pardos et al. · 2022 · Nature Communications
  98. Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics
    Ratz, Michael, von Berlin, Leonie, Larsson, Ludvig, Martin, Marcel, Westholm, Jakub Orzechowski, La Manno, Gioele, Lundeberg, Joakim, Frisén, Jonas · 2022 · Nature Neuroscience
  99. Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons
    Kaya J.E. Matson, Daniel E. Russ, Claudia Kathe, Isabelle Hua, Dragan Maric, Yi Ding, Jonathan Krynitsky, Randall H. Pursley, Anupama Sathyamurthy, Jordan W. Squair et al. · 2022 · Nature Communications
  100. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
    Mendiola, Andrew S., Yan, Zhaoqi, Dixit, Karuna, Johnson, Jeffrey R., Bouhaddou, Mehdi, Meyer-Franke, Anke, Shin, Min-Gyoung, Yong, Yu, Agrawal, Ayushi, MacDonald, Eilidh et al. · 2023 · Nature Immunology