Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip, Hurle, Mark, Gutteridge, Alex, Erola, Pau +26 more·2019·Nature Genetics

Cited by (834)

Items 101–200 of 834

  1. Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes
    Alexander Haglund, Verena Zuber, Maya Abouzeid, Yifei Yang, Jeong Hun Ko, Liv Wiemann, Maria Otero‐Jimenez, Louwai Muhammed, Rahel Feleke, Alexi Nott et al. · 2025 · Nature Genetics
  2. Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
    Bretherick, Andrew D., Canela-Xandri, Oriol, Joshi, Peter K., Clark, David W., Rawlik, Konrad, Boutin, Thibaud S., Zeng, Yanni, Amador, Carmen, Navarro, Pau, Rudan, Igor et al. · 2020 · PLOS Genetics
  3. Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction
    Ziyi Sun, Zhangjun Yun, Jianguo Lin, Xiaoning Sun, Qingqing Wang, Jinlong Duan, Cheng Li, Xiaoxiao Zhang, Siyu Xu, Zeqi Wang et al. · 2024 · Journal of Translational Medicine
  4. Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity
    Amand Floriaan Schmidt, Mimount Bourfiss, Abdulrahman I. Alasiri, Esther Puyol Anton, Sandesh Chopade, Marion van Vugt, Sander W. van der Laan, Christian Groß, Chris Clarkson, Albert Henry et al. · 2023 · Science Advances
  5. Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
    Qianqian Peng, Xinxuan Liu, Wenran Li, Han Jing, Jiarui Li, Xingjian Gao, Qi Luo, Charles E. Breeze, Siyu Pan, Qiwen Zheng et al. · 2024 · Nature Genetics
  6. Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease
    Satoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini, Chen‐Yang Su, Yiheng Chen, Kevin Y. H. Liang, Julian Willett, Shidong Wang, Darin Adra et al. · 2025 · Nature Genetics
  7. It’s in Our Blood: A Glimpse of Personalized Medicine
    John R. Lamb, Lori L. Jennings, Valborg Guðmundsdóttir, Vilmundur G. Gudnason, Valur Emilsson · 2020 · Trends in Molecular Medicine
  8. Large‐Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure
    Lars Lind, Daniela Zanetti, Martin Ingelsson, Stefan Gustafsson, Johan Ärnlöv, Themistocles L. Assimes · 2021 · Journal of the American Heart Association
  9. RSPO3 is important for trabecular bone and fracture risk in mice and humans
    Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen et al. · 2021 · Nature Communications
  10. Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
    Long Zhang, Yajun Xiong, Jie Zhang, Yuying Feng, Aiguo Xu · 2024 · Journal of Translational Medicine
  11. Genetic regulation of post-translational modification of two distinct proteins
    Arianna Landini, Irena Trbojević‐Akmačić, Pau Navarro, Yakov A. Tsepilov, Sodbo Sharapov, Frano Vučković, Ozren Polašek, Caroline Hayward, Tea Pribić, Marija Ćapin Vilaj et al. · 2022 · Nature Communications
  12. Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome
    Zuodong Ning, Yunying Huang, Haocheng Lu, Yong Zhou, Tao Tu, Feifan Ouyang, Yaozhong Liu, Qiming Liu · 2023 · Cardiovascular Drugs and Therapy
  13. Exploring noncoding variants in genetic diseases: from detection to functional insights
    Ke Wu, Fengxiao Bu, Yang Wu, Gen Zhang, Xin Wang, Shunmin He, Mo‐Fang Liu, Runsheng Chen, Huijun Yuan · 2024 · Journal of genetics and genomics/Journal of Genetics and Genomics
  14. Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity
    Jie Zheng, Yuemiao Zhang, Huiling Zhao, Yi Liu, Denis A. Baird, Mohd Anisul Karim, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Benjamin Elsworth et al. · 2022 · EBioMedicine
  15. Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
    James Yarmolinsky, Emmanouil Bouras, Andrei‐Emil Constantinescu, Kimberley Burrows, Caroline J. Bull, Emma E. Vincent, Richard Michael Martin, Olympia Dimopoulou, Sarah Jane Lewis, Victor Rau Moreno et al. · 2023 · Diabetologia
  16. Promising therapeutic targets for ischemic stroke identified from plasma and cerebrospinal fluid proteomes: a multicenter Mendelian randomization study
    Xuelun Zou, Lei‐Yun Wang, Sai Wang, Yupeng Zhang, Junyi Ma, Lei Chen, Ye Li, Tianxing Yao, Huifang Zhou, Lianxu Wu et al. · 2023 · International Journal of Surgery
  17. An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs
    Yang Zhang, Mengyao Wang, Zhenguo Li, Xuan Yang, Keqin Li, Ao Xie, Fang Dong, Shihan Wang, Jianbing Yan, Jianxiao Liu · 2024 · Science China Life Sciences
  18. Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis
    Jie Zheng, Monika Frysz, John P. Kemp, David M. Evans, George Davey Smith, Jonathan H. Tobias · 2019 · Frontiers in Endocrinology
  19. Proteomics: Progress and Promise of High-Throughput Proteomics in Chronic Kidney Disease
    Pascal Schlosser, Morgan Erika Grams, Eugene P. Rhee · 2023 · Molecular & Cellular Proteomics
  20. Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
    Feihong Ren, Qiubai Jin, Tongtong Liu, Ren Xuelei, Yongli Zhan · 2023 · Journal of Translational Medicine
  21. Therapeutic Targets for Diabetic Kidney Disease: Proteome-Wide Mendelian Randomization and Colocalization Analyses
    Wei Zhang, Leilei Ma, Qianyi Zhou, Tianjiao Gu, Xiaotian Zhang, Haitao Xing · 2024 · Diabetes
  22. Proteome-wide Systems Genetics to Identify Functional Regulators of Complex Traits
    Jeffrey Molendijk, Benjamin L. Parker · 2021 · Cell Systems
  23. An efficient and robust tool for colocalisation: Pair-wise Conditional and Colocalisation (PWCoCo)
    Jamie W. Robinson, Gibran Hemani, Mahsa Sheikhali Babaei, Yunfeng Huang, Denis A. Baird, Ellen A. Tsai, Chia‐Yen Chen, Tom R. Gaunt, Jie Zheng · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study
    Jie Zheng, Min Xu, Qian Yang, Chunyan Hu, Venexia M. Walker, Jieli Lu, Jiqiu Wang, Ruixin Liu, Yu Xu, Tiange Wang et al. · 2023 · EBioMedicine
  25. The contribution of genetic determinants of blood gene expression and splicing to molecular phenotypes and health outcomes
    Alex Tokolyi, Elodie Persyn, Artika P. Nath, Katie L. Burnham, Jonathan Marten, Thomas Vanderstichele, Manuel Tardáguila, David Stacey, Ben W. Farr, Vivek Iyer et al. · 2025 · Nature Genetics
  26. Mapping the plasma metabolome to human health and disease in 274,241 adults
    Jia You, Xi-Han Cui, Yilin Chen, Yixuan Wang, Haiyun Li, Yi‐Xuan Qiang, Ji-Yun Cheng, Yue‐Ting Deng, Yu Guo, Peng Ren et al. · 2025 · Nature Metabolism
  27. Why clinicians should know about Mendelian randomization
    Sizheng Steven Zhao, Sarah Louise Mackie, Jie Zheng · 2021 · Rheumatology
  28. Associations of Insomnia With Insulin Resistance Traits: A Cross-sectional and Mendelian Randomization Study
    Xiaoyu Wang, Chenhao Zhao, Hongliang Feng, Guohua Li, Lei He, Lulu Yang, Yan Liang, Xiao Wei Tan, Yanmin Xu, Ruixiang Cui et al. · 2023 · The Journal of Clinical Endocrinology & Metabolism
  29. Statins as Potential Chemoprevention or Therapeutic Agents in Cancer: a Model for Evaluating Repurposed Drugs
    Nalinie Joharatnam‐Hogan, Leo Alexandre, James Yarmolinsky, Blossom Lake, Nigel E. Capps, Richard Michael Martin, Alistair E. Ring, Fay Helen Cafferty, Ruth Elizabeth Langley · 2021 · Current Oncology Reports
  30. Crosstalk between Statins and Cancer Prevention and Therapy: An Update
    Beniamin Oskar Grabarek, Dariusz Boroń, Emilia Morawiec, Piotr Michalski, Veronica Palazzo-Michalska, Łukasz Pach, Barbara Dziuk, Magdalena Świder, Nikola Zmarzły · 2021 · Pharmaceuticals
  31. Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage
    Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya Surapaneni, Eugene P. Rhee, Dan E. Arking, Bing Yu, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee et al. · 2023 · Genome biology
  32. Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities
    Shuai Yuan, Fengzhe Xu, Han Zhang, Jie Chen, Xixian Ruan, Yuying Li, Stephen Burgess, Agneta Åkesson, Xue Li, Dipender Gill et al. · 2023 · Journal of Thrombosis and Haemostasis
  33. Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation
    Marion van Vugt, Chris Finan, Sandesh Chopade, Rui Andre Providencia, Connie R. Bezzina, Folkert Wouter Asselbergs, Jessica van Setten, Amand Floriaan Schmidt · 2024 · Genome Medicine
  34. Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
    Smith-Byrne, Karl, Hedman, Åsa, Dimitriou, Marios, Desai, Trishna, Sokolov, Alexandr V., Schioth, Helgi B., Koprulu, Mine, Pietzner, Maik, Langenberg, Claudia, Atkins, Joshua et al. · 2024 · Nature Communications
  35. Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
    María Gordillo‐Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Juan Pablo Casas, Nishi Chaturvedi, Olia Papacosta et al. · 2021 · Nature Communications
  36. Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets
    Yanggang Hong, Yi Wang, Wanyi Shu · 2024 · Journal of Affective Disorders
  37. Review of Mendelian Randomization Studies on Endometrial Cancer
    Jian-Zeng Guo, Qi‐Jun Wu, Fang-Hua Liu, Chang Gao, Ting‐Ting Gong, Gang Li · 2022 · Frontiers in Endocrinology
  38. Target Discovery for Drug Development Using Mendelian Randomization
    Daniel S. Evans · 2022 · Methods in molecular biology
  39. Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis
    Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou et al. · 2022 · Journal of Crohn s and Colitis
  40. Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
    Yi Chen, Guiquan Wang, Jingqiao Chen, Congying Wang, Xi Dong, Hsun‐Ming Chang, Shuai Yuan, Yue Zhao, Liangshan Mu · 2024 · Endocrine Reviews
  41. Genetically supported targets and drug repurposing for brain aging: A systematic study in the UK Biobank
    Yi Fan, Jing Yuan, Judith Somekh, Mor Peleg B, Yi‐Cheng Zhu, Zhilong Jia, Fei Ling Wu, Zhengxing Huang · 2025 · Science Advances
  42. A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance
    Mohd Anisul Karim, Jarrod Shilts, Jeremy Schwartzentruber, James D. Hayhurst, Annalisa Buniello, Elmutaz Shaikho Elhaj Mohammed, Jie Zheng, Michael Vaclav Holmes, David Ochoa, Miguel Carmona et al. · 2021 · eLife
  43. A novel multi-ancestry proteome-wide Mendelian randomization study implicates extracellular proteins, tubular cells, and fibroblasts in estimated glomerular filtration rate regulation
    Matthew Bruce Lanktree, Nicolas Perrot, Andrew Smyth, Michael Chong, Sukrit Narula, Meera Shanmuganathan, Zachary Kroezen, Philip Britz‐McKibbin, Mario Berger, Joan C. Krepinsky et al. · 2023 · Kidney International
  44. Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis
    Min Seo Kim, Minku Song, Beomsu Kim, Injeong Shim, Dan Say Kim, Pradeep Natarajan, Ron Do, Hong‐Hee Won · 2023 · Cell Reports Medicine
  45. Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers
    Molly Went, Amit Sud, Charlie Mills, Abi Hyde, Richard Culliford, Philip Law, Jayaram Vijayakrishnan, Ines Gockel, Carlo Maj, Johannes Schumacher et al. · 2024 · Nature Communications
  46. Transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-related drug targets for cardiometabolic diseases
    Xueyan Wu, Hui Ying, Qianqian Yang, Qian Yang, Haoyu Liu, Yilan Ding, Huiling Zhao, Zhihe Chen, Ruizhi Zheng, Hong Lin et al. · 2024 · Nature Communications
  47. Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19
    Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li et al. · 2025 · EBioMedicine
  48. mGWAS-Explorer 2.0: Causal Analysis and Interpretation of Metabolite–Phenotype Associations
    Le Chang, Guangyan Zhou, Jianguo Xia · 2023 · Metabolites
  49. Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
    Trishna A. Desai, Åsa K. Hedman, Marios Dimitriou, Mine Koprulu, Sandy Figiel, Wencheng Yin, Mattias Johansson, Eleanor L. Watts, Joshua R. Atkins, Aleksandr V. Sokolov et al. · 2024 · EBioMedicine
  50. Multi-ancestry genome-wide association analyses of polycystic ovary syndrome
    Han Zhao, Yuping Xu, Baiqiang Xue, Shigang Zhao, Manfei Zhang, Xiaoke Wu, Tianjuan Wang, Yanqin Wen, Shumin Li, Qing Zhang et al. · 2025 · Nature Genetics
  51. Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
    Sirui Zhou, Olukayode Ayodeji Sosina, Jonas Bovijn, Laetitia Laurent, Vasundhara Sharma, Parsa Akbari, Vincenzo Forgetta, Lai Jiang, Jack A. Kosmicki, Nilanjana Banerjee et al. · 2023 · Nature Genetics
  52. GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels
    Ingrid Gergei, Jie Zheng, Till F. M. Andlauer, Vincent Mathias Brandenburg, Nazanin Mirza‐Schreiber, Bertram Müller‐Myhsok, Bernhard Karl Krämer, Daniel J. Richard, Louise Falk, Sofia Movérare‐Skrtic et al. · 2021 · Human Molecular Genetics
  53. Identification of prospective aging drug targets via Mendelian randomization analysis
    Rui Mao, Ji Li, Wenqin Xiao · 2024 · Aging Cell
  54. Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s disease
    Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li · 2024 · Nature Communications
  55. The effect of SGLT2 inhibition on prostate cancer: Mendelian randomization and observational analysis using electronic healthcare and cohort data
    Jie Zheng, Jieli Lu, Jiying Qi, Qian Yang, Huiling Zhao, Haoyu Liu, Zhihe Chen, Lanhui Huang, Youqiong Ye, Min Xu et al. · 2024 · Cell Reports Medicine
  56. Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits
    Jeffrey Okamoto, Lijia Wang, Xianyong Yin, Francesca Luca, Roger Piqué-Regi, Adam S. Helms, Hae Kyung Im, Jean Morrison, Xiaoquan Wen · 2023 · The American Journal of Human Genetics
  57. Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders
    Xiaoyan Li, Aotian Shen, Yiran Zhao, Junfeng Xia · 2023 · Schizophrenia Bulletin
  58. SharePro: an accurate and efficient genetic colocalization method accounting for multiple causal signals
    Wenmin Zhang, Tianyuan Lu, ROBERT M. SLADEK, Yue Li, Hamed Shateri Najafabadi, Josée Dupuis · 2024 · Bioinformatics
  59. Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
    Jing Hua Zhao, David Stacey, Niclas Eriksson, Erin Macdonald-Dunlop, Åsa K. Hedman, Anette Kalnapenkis, Stefan Enroth, Domenico Cozzetto, Jonathan L. Digby-Bell, Jonathan Marten et al. · 2023 · Nature Immunology
  60. Mendelian randomization identifies proteins involved in neurodegenerative diseases
    Lazaros Belbasis, Sam Morris, Cornelia M. van Duijn, Derrick Bennett, Robin G. Walters · 2025 · Brain
  61. Causal Inference Methods to Integrate Omics and Complex Traits
    Eleonora Porcu, Jennifer Sjaarda, Kaido Lepik, Cristian Carmeli, Liza Darrous, Jonathan Sulc, Ninon Mounier, Zoltán Kutalik · 2020 · Cold Spring Harbor Perspectives in Medicine
  62. Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder
    William R. Reay, Michael P. Geaghan, Joshua Ronald Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns · 2022 · The American Journal of Human Genetics
  63. Examining the biological mechanisms of human mental disorders resulting from gene-environment interdependence using novel functional genomic approaches
    Patrícia Pelufo Silveira, Michael Joseph Meaney · 2023 · Neurobiology of Disease
  64. Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization
    Tianzhichao Hou, Huajie Dai, Qi Wang, Yanan Hou, Xiaoyun Zhang, Hong Lin, Shuangyuan Wang, Mian Li, Zhiyun Zhao, Jieli Lu et al. · 2023 · Frontiers in Immunology
  65. Complex effects of sequence variants on lipid levels and coronary artery disease.
    Audunn S. Snaebjarnarson, A. Helgadóttir, G. Arnadottir, Erna V. Ivarsdottir, G. Thorleifsson, E. Ferkingstad, G. Einarsson, G. Sveinbjornsson, T. Thorgeirsson, M. O. Ulfarsson et al. · 2023 · Cell
  66. Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases
    Maria Sobczyk, Jie Zheng, George Davey Smith, Tom R. Gaunt · 2023 · BMJ Open
  67. Proteome-Wide Mendelian Randomization and Colocalization Analysis Identify Therapeutic Targets for Knee and Hip Osteoarthritis
    Mingrui Zou, Zhenxing Shao · 2024 · Biomolecules
  68. Identification of drug targets for Sjögren’s syndrome: multi-omics Mendelian randomization and colocalization analyses
    Yingjie Bai, Jiayi Wang, Xuefeng Feng, Le Xie, Shengao Qin, Guowu Ma, Fan Zhang · 2024 · Frontiers in Immunology
  69. A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer
    Aayah Nounu, Alexander Greenhough, Kate J. Heesom, Rebecca Claire Richmond, Jie Zheng, Stephanie J. Weinstein, Demetrius Albanes, John A. Baron, John Llewelyn Hopper, Jane C. Figueiredo et al. · 2021 · Cancer Epidemiology Biomarkers & Prevention
  70. The goldmine of GWAS summary statistics: a systematic review of methods and tools
    Panagiota I. Kontou, Pantelis G. Bagos · 2024 · BioData Mining
  71. Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study
    Tomoko Nakanishi, Agustin Cerani, Vincenzo Forgetta, Sirui Zhou, Richard J. Allen, Olivia C. Leavy, Masaru Koido, Deborah Assayag, Gisli R. Jenkins, Louise V. Wain et al. · 2021 · European Respiratory Journal
  72. How humans can contribute to Mendelian randomization analyses.
    Burgess, Stephen, Davey Smith, George · 2019 · International Journal of Epidemiology
  73. COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection
    Yuxuan Wang, Suri Guga, Kejia Wu, Zoe Khaw, Konstantinos Tzoumkas, Phil Tombleson, Mary E. Comeau, Carl D. Langefeld, Deborah S. Cunninghame Graham, David Lester Morris et al. · 2022 · PLoS Genetics
  74. Circulating Proteins and IgA Nephropathy
    Chen Tang, Pei Chen, Lin-Lin Xu, Jicheng Lv, Sufang Shi, Shu‐Feng Zhou, Lijun Liu, Hong Zhang · 2024 · Journal of the American Society of Nephrology
  75. Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility
    Jamie W. Robinson, Richard Michael Martin, Spiridon Tsavachidis, Amy Howell, Caroline Laura Relton, Georgina Armstrong, Melissa L. Bondy, Jie Zheng, Kathreena Mary Kurian · 2021 · Scientific Reports
  76. The role of proteomics in defining autoimmunity
    Darja Kanduc · 2021 · Expert Review of Proteomics
  77. Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank
    Robert Francis Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tin-Chi Lin, Kyle L. Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Eric Marshall et al. · 2024 · Nature Communications
  78. Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice
    Yaozhong Liu, Minzhi Yu, Huilun Helen Wang, Kristen W. Hong, Yalun Cheng, Ying Zhao, Yonghong Luo, Guizhen Zhao, Yang Zhao, Haocheng Lu et al. · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
  79. Genome-Wide Mapping of Plasma IgG N-Glycan Quantitative Trait Loci Identifies a Potentially Causal Association between IgG N-Glycans and Rheumatoid Arthritis
    Di Liu, Jing Dong, Jie Zhang, Xizhu Xu, Qiuyue Tian, Xiaoni Meng, Lijuan Wu, Deqiang Zheng, Xi Chu, Wei Wang et al. · 2022 · The Journal of Immunology
  80. Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits
    Sylvanus Toikumo, Heng Xu, Joel E. Gelernter, Rachel L. Kember, Henry R. Kranzler · 2022 · Neuropsychopharmacology
  81. An atlas of genetic determinants of forearm fracture
    Maria Nethander, Sofia Movérare‐Skrtic, Anders J. Kämpe, Eivind Coward, Ene Reimann, Louise Grahnemo, Éva Borbély, Zsuzsanna Helyes, Thomas Funck‐Brentano, Martine Esther Cohen-Solal et al. · 2023 · Nature Genetics
  82. Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets
    Su, Chen-Yang, van der Graaf, Adriaan, Zhang, Wenmin, Jang, Dong-Keun, Selber-Hnatiw, Susannah, Yang, Ta-Yu, Butler-Laporte, Guillaume, Liang, Kevin Y. H., Matsuda, Fumihiko, Costanzo, Maria C. et al. · 2024
  83. Identification of potential therapeutic targets for Alzheimer's disease from the proteomes of plasma and cerebrospinal fluid in a multicenter Mendelian randomization study
    Shengnan Wang, Jianxin Xi, Mengyuan Zhang, Jianglong Wang · 2025 · International Journal of Biological Macromolecules
  84. Plasma proteomics identify novel biomarkers and dynamic patterns of biological aging
    Lingzhi Ma, Weishi Liu, Yu He, Yi Zhang, Jia You, Jianfeng Feng, Lan Tan, Wei Cheng, Jin-Tai Yu · 2025 · Journal of Advanced Research
  85. Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait
    Yanwei Cai, Nora Franceschini, Aditya Surapaneni, Melanie E. Garrett, Usman A. Tahir, Li Hsu, Marilyn J. Telen, Bing Yu, Hua Tang, Yun Li et al. · 2023 · Clinical Journal of the American Society of Nephrology
  86. Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure
    Qian-Qian Yang, Qian Yang, Xue-Yan Wu, R. Zheng, Hong Lin, Shuang-Yuan Wang, Jacob Joseph, Yan V. Sun, Mian Li, Tian-Ge Wang et al. · 2024 · Cell Reports Medicine
  87. Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations
    Rédouane Aherrahrou, Ferheen Baig, Konstantinos Theofilatos, Dillon Lue, Alicia Beele, Tiit Örd, Minna Unelma Kaikkonen, Zouhair Aherrahrou, Qi Cheng, Saikat Ghosh et al. · 2024 · Arteriosclerosis Thrombosis and Vascular Biology
  88. Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study
    Yurong Cheng, Yong Li, Nora Scherer, Franziska Grundner-Culemann, Terho J. Lehtimäki, Binisha Hamal Mishra, Olli Tuomas Raitakari, Matthias A. Nauck, Kai‐Uwe Eckardt, Peggy Sekula et al. · 2022 · PLoS Genetics
  89. Hypertriglyceridemia as a Key Contributor to Abdominal Aortic Aneurysm Development and Rupture: Insights From Genetic and Experimental Models
    Yaozhong Liu, Huilun Helen Wang, Minzhi Yu, Lei Cai, Ying Zhao, Yalun Cheng, Yongjie Deng, Yang Zhao, Haocheng Lu, Xiaokang Wu et al. · 2025 · Circulation
  90. High-throughput proteomic analysis reveals systemic dysregulation in virally suppressed people living with HIV
    Nadira Vadaq, Yue Zhang, Wilhelm A. J. W. Vos, Albert L. Groenendijk, Martinus J.T. Blaauw, Louise E. van Eekeren, Maartje C. P. Cleophas, Lisa Van de Wijer, Jéssica Cristina dos Santos, Muhammad Hussein Gasem et al. · 2023 · JCI Insight
  91. Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions
    Christina Dardani, Jamie W. Robinson, Hannah J Jones, Dheeraj Rai, Evie Stergiakouli, Jakob Grove, Renee M. Gardner, Andrew Mark McIntosh, Alexandra Havdahl, Gibran Hemani et al. · 2025 · Molecular Psychiatry
  92. Mendelian randomization under the omnigenic architecture
    Lu Wang, Boran Gao, Yue Fan, Fuzhong Xue, Xiang Zhou · 2021 · Briefings in Bioinformatics
  93. Proteome-wide Mendelian randomization and functional studies uncover therapeutic targets for polycystic ovarian syndrome
    Fei-Da Ni, Feixia Wang, Jing Sun, Mixue Tu, Jianpeng Chen, Xiling Shen, Xiaohang Ye, Ruixue Chen, Yifeng Liu, Xiao Sun et al. · 2024 · The American Journal of Human Genetics
  94. Integrating multi-omics and artificial intelligence fuels advanced target identification and drug discovery
    Hang Chen, Ying Shi, Meiling Yuan, Huihui Li, Xiaowei Liu · 2025 · Biotechnology Advances
  95. Network analysis of genome-wide association studies for drug target prioritisation
    Inigo Barrio‐Hernandez, Pedro Beltrão · 2022 · Current Opinion in Chemical Biology
  96. Synthesis of Surface-Functionalized Molybdenum Disulfide Nanomaterials for Efficient Adsorption and Deep Profiling of the Human Plasma Proteome by Data-Independent Acquisition
    Yuanyuan Liu, Qianying Yang, Zhuokun Du, Jiayu Liu, Yangjun Zhang, Wanjun Zhang, Weijie Qin · 2022 · Analytical Chemistry
  97. Evaluation of the Effect of Sodium-Glucose Cotransporter 2 Inhibition on Fracture Risk: Evidence From Mendelian Randomization and Genetic Association Study
    Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng et al. · 2023 · Journal of Bone and Mineral Research
  98. Exploration of potential novel drug targets and biomarkers for small cell lung cancer by plasma proteome screening
    Yijun Wu, Zhile Wang, Yuqi Yang, Han Chang, Li Wang, Kai Kang, Ailin Zhao · 2023 · Frontiers in Pharmacology
  99. Proteome-wide Mendelian randomization identifies causal plasma proteins in lung cancer
    Hongru Li, Sha Du, Jinglan Dai, Yunke Jiang, Zaiming Li, Qihan Fan, Yixin Zhang, Dongfang You, Ruyang Zhang, Yang Zhao et al. · 2024 · iScience
  100. Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Qinnan Zhang, Boyuan Ma, Jinyu Chen, Bitao Wang, Jun Ma, Derong Liu, Jian Hao, Xianhu Zhou · 2024 · Arthritis Research & Therapy