Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.

Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip, Hurle, Mark, Gutteridge, Alex, Erola, Pau +26 more·2019·Nature Genetics

Cited by (834)

Items 701–800 of 834

  1. Additional file 2 of Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
    Zhang, Long, Yajun Xiong, Zhang, Jie, Yuying Feng, Xu, Aiguo · 2024 · Figshare
  2. Additional file 10 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  3. Additional file 1 of Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction
    Sun, Ziyi, Yun, Zhangjun, Lin, Jianguo, Sun, Xiaoning, Qingqing Wang, Duan, Jinlong, Li, Cheng, Xiaoxiao Zhang, Xu, Siyu, Zeqi Wang et al. · 2024 · Figshare
  4. Additional file 1 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  5. Additional file 8 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  6. Additional file 1 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  7. Additional file 3 of Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
    Chen, Shuming, Weidi Huang, Qiaoqian Wan, Zichun Tang, Li, Xie, Zeng, Fang, Zheng, Shuyan, Zhuo Li, Liu, Xiao · 2024 · Figshare
  8. Additional file 6 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  9. Additional file 2 of Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction
    Sun, Ziyi, Yun, Zhangjun, Lin, Jianguo, Sun, Xiaoning, Qingqing Wang, Duan, Jinlong, Li, Cheng, Zhang, Xiaoxiao, Xu, Siyu, Zeqi Wang et al. · 2024 · Figshare
  10. Additional file 7 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  11. Additional file 8 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  12. Additional file 6 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  13. Additional file 4 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  14. Additional file 2 of Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
    Chen, Shuming, Weidi Huang, Qiaoqian Wan, Zichun Tang, Li, Xie, Zeng, Fang, Zheng, Shuyan, Zhuo Li, Liu, Xiao · 2024 · Figshare
  15. Additional file 2 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  16. Additional file 11 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  17. Additional file 1 of Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
    Emmanouil Bouras, Ville Karhunen, Dipender Gill, Huang, Jian, Haycock, Philip C., Marc J. Gunter, Johansson, Mattias, Paul Brennan, Key, Tim, Sarah Jane Lewis et al. · 2022 · Figshare
  18. Additional file 1 of Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma
    Zhang, Long, Yajun Xiong, Zhang, Jie, Yuying Feng, Xu, Aiguo · 2024 · Figshare
  19. Additional file 5 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  20. Additional file 2 of Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage
    Pascal Schlosser, Zhang, Jingning, Liu, Hongbo, Surapaneni, Aditya L., Eugene P. Rhee, Dan E. Arking, Yu, Bing, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee et al. · 2023 · Figshare
  21. Additional file 1 of Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses
    Cao, Min, Bin Cui · 2024 · Figshare
  22. Additional file 5 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Boyuan Ma, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  23. Additional file 4 of Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
    Chen, Shuming, Weidi Huang, Qiaoqian Wan, Zichun Tang, Li, Xie, Zeng, Fang, Zheng, Shuyan, Zhuo Li, Xiao Liu · 2024 · Figshare
  24. Additional file 2 of Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis
    Li, Jiao, Wang, Fei, Li, Zhen, Feng, Jingjing, Men, Yi, Han, Jinming, Xia, Jiangwei, Zhang, Chen, Yilai Han, Chen, Teng et al. · 2024 · Figshare
  25. Additional file 4 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  26. Additional file 2 of Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome
    Jing Sun, Zhao, Jianhui, Fangyuan Jiang, Lijuan Wang, Xiao, Qian, Han, Fengyan, Chen, Jie, Yuan, Shuai, Jingsun Wei, Larsson, Susanna C. et al. · 2023 · Figshare
  27. Additional file 3 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  28. Additional file 4 of Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
    Emmanouil Bouras, Ville Karhunen, Dipender Gill, Huang, Jian, Haycock, Philip C., Marc J. Gunter, Johansson, Mattias, Paul Brennan, Key, Tim, Sarah Jane Lewis et al. · 2022 · Figshare
  29. Additional file 1 of Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
    Cai, Yi-Xin, Wu, Yi-Qing, Liu, Jie, Huanle Pan, Deng, Wenhai, Sun, Weijian, Xie, Congying, Huang, Xiu-Feng · 2023 · Figshare
  30. Additional file 3 of Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage
    Pascal Schlosser, Zhang, Jingning, Liu, Hongbo, Surapaneni, Aditya L., Eugene P. Rhee, Dan E. Arking, Yu, Bing, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee et al. · 2023 · Figshare
  31. Additional file 1 of Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers
    Ren, Feihong, Jin, Qiubai, Liu, Tongtong, Ren, Xuelei, Zhan, Yongli · 2024 · Figshare
  32. Additional file 1 of Mendelian randomization and colocalization analysis reveal novel drug targets for myasthenia gravis
    Yuzhen Ouyang, Chen, Yu, Kangzhi Chen, Tang, Zhenwei, Guanzhong Shi, Qu, Chunrun, Kaiyue Zhang, Yang, Huan · 2024 · Figshare
  33. Additional file 1 of Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics
    Chen, Shuming, Weidi Huang, Qiaoqian Wan, Zichun Tang, Li, Xie, Zeng, Fang, Zheng, Shuyan, Zhuo Li, Liu, Xiao · 2024 · Figshare
  34. Additional file 9 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  35. Additional file 3 of Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
    Emmanouil Bouras, Ville Karhunen, Dipender Gill, Huang, Jian, Haycock, Philip C., Marc J. Gunter, Johansson, Mattias, Paul Brennan, Tim Key, Sarah Jane Lewis et al. · 2022 · Figshare
  36. Additional file 1 of Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis
    Li, Jiao, Wang, Fei, Li, Zhen, Feng, Jingjing, Men, Yi, Han, Jinming, Xia, Jiangwei, Zhang, Chen, Yilai Han, Chen, Teng et al. · 2024 · Figshare
  37. Additional file 7 of Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
    Kaixi Ding, Juejue Zhangwang, Lei, Ming, Chunping Xiong · 2024 · Figshare
  38. Additional file 3 of Single-cell and genome-wide Mendelian randomization identifies causative genes for gout
    Yubiao Yang, Ping Hu, Zhang, Qinnan, Ma, Boyuan, Jinyu Chen, Wang, Bitao, Jun Ma, Derong Liu, Jian Hao, Zhou, Xianhu · 2024 · Figshare
  39. Therapeutic targets for epilepsy identified using proteomics and Mendelian randomization
    Xiaotong Li, Yan Wang, Chunhua Song, Xiaojing Guo · 2025 · In Silico Research in Biomedicine
  40. Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study
    Ziyuan Wang, Miao Zhang, Cong Liu, Yiyin Zhang, Rong Cheng, Suli Zhang, Bin Yang, Li Wang, Junhong Guo, Xiaohui Wang · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
  41. Identification of Novel Biomarkers and Potential Therapeutic Targets for Systemic Sclerosis: An Integrated Analysis of Plasma Proteome-Wide Mendelian Randomization and Transcriptome
    Hanchao Li, Qian Li, Xiaoxin Chen, Lingfei Mo, Yulu Wang, Xinyi Liu, Xiaohao Wang, Zechao Qu, Jing Wang, Yuanyuan Li · 2025 · Journal of Inflammation Research
  42. Cell-type–specific genetic architecture of postpartum depression: A single-cell Mendelian randomization framework for causal gene discovery
    Yu Huang, Qiu-Han Xu, K. Chin Chen, Huai-Fang Li, Yang Yang · 2025 · Journal of Affective Disorders
  43. Unveiling novel potential drug targets for lung cancer through Mendelian randomization analysis
    Yawei Huang, Mengya Geng, Mukun Zhang · 2025 · Scientific Reports
  44. Uncovering plasma protein biomarkers linked to depression: A differential abundance analysis and Mendelian randomization using large-scale data
    Endeshaw Chekol Abebe, Anwar Mulugeta, Iqbal Madakkatel, David Stacey, Elina Hyppönen · 2026 · Journal of Affective Disorders
  45. Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study
    Junchi Guo, F. Huang, Peihan Lu, Mei-Juan Lu · 2026 · Cardiovascular Therapeutics
  46. Mendelian Randomization Analysis of the Brain, Cerebrospinal Fluid, and Plasma Proteome Identifies a Potential Peripheral Biomarker for Isolated REM Sleep Behavior Disorder
    Hong Ye, Zhenzhen Liu, Y. H. Huang, Na Xu, Caiping Jiang, Qiuhan Xu, Xuxia Zhou · 2026 · Journal of Molecular Neuroscience
  47. Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications
    Jiajia Chen, Lingyu Chang, Xianyang Hu, Jiani Guo, Yang Yan, Dajin Li, Jinlong Qin, Meirong Du, Weijie Zhao · 2026 · Clinical Science
  48. Identifying novel therapeutic targets for glioblastoma: Insights from plasma proteome analysis
    Ningning Yao, Mingzhao Su, Fang Lei, Hui Wang, Xin Sun, Aolin Li, Yucheng Lu · 2026 · In Silico Research in Biomedicine
  49. Integrating plasma proteomes with genome-wide association data for causal protein identification in hepatocellular carcinoma: A bidirectional Mendelian randomization study
    Xue Chen, Zhen Zheng, Jing Hu, Shuang Ye, KaiTai Liu · 2026 · Medicine
  50. Mendelian Randomization Transcriptomics and Network Pharmacology for Identification of Osteoarthritis Drug Targets
    Zhiwei Zhang, Min Tu, Ning Yuan, Wenqiang Qian, Guopeng Wang, Maohua Lin, Jiefei Xie, Li Liang, Jian Guo, Bin Zhang et al. · 2026 · Journal of Visualized Experiments
  51. 58 risk and 34 protective effects of GLP1R on disease phenome and adverse neonatal health
    Robert H Campbell, Melinda C Mills · 2026 · medRxiv
  52. Plasma proteome mendelian randomization and network pharmacology reveal therapeutic targets for thyroid disorders
    Chao Wang, Yi Cai, Xing Yang, Jie Jie · 2026 · Molecular and Cellular Endocrinology
  53. Large-Scale Identification of Novel Protein Biomarkers and Therapeutic Targets in Heart and Brain Disease
    Chao Jun Wu, Dantong Li, Sumeet A. Khetarpal, Zixun Yuan, Shengyuan Huang, Justin Ralph Baldovino Guerra, Chunyu Li, Qiulian Zhou, Meixi Quan, Jiaqi He et al. · 2026 · medRxiv
  54. The shared genetic architecture underlying the autoimmune and cardiovascular disease: a multivariate genome-wide analysis
    Jie Zhang, Xinyu Fang, Qian-Ling Ye, X. Yin, Dongqing Ye · 2026 · Cardiovascular Diabetology
  55. Exploration and discovery of treatment targets for primary biliary cholangitis based on plasma and cerebrospinal fluid proteomics: A multicenter mendelian randomization study
    Jianxin Xi, Shengnan Wang, Jie Chen, Jason Chi Shing Law, Jianglong Wang, Guan Huei Lee, Zhongqi Fan, Guoyue Lv, Yuguo Chen · 2026 · PLoS ONE
  56. Impact of proteogenomic evidence on clinical success
    Mohd Anisul Karim, Abhay Hukku, Bruno Ariano, Emily Rose Holzinger, Yakov A. Tsepilov, James D. Hayhurst, Annalisa Buniello, Ellen M. McDonagh, Stephane E. Castel, Matthew R. Nelson et al. · 2026 · medRxiv
  57. Proteome-wide Mendelian randomization and colocalization analyses identify potential biomarkers for schizophrenia
    Jingyu Lin, Haiming Huang, L Chen, Yanyan Wei, Tianmei Si, Su YA, Yajuan Niu, Jingxu Chen · 2026 · Frontiers in Psychiatry
  58. Deciphering the multi-target mechanisms of TCM formulas in hyperlipidemia treatment through meta-multi-omics data and UK Biobank analysis
    Xiyue Chang, Jiayue Qiu, Zihan Wang, Zheng Wu, Yunwen Feng, Kit-Leong Cheong, Lili Yu, Yongshuai Jiang, Chen Huang · 2026 · European Journal of Integrative Medicine
  59. A Mendelian randomization-based drug repurposing pipeline with integrated AI-facilitated prioritization: application to lipid traits and coronary artery disease
    Sergio Mundo, Monika E. Grabowska, Alyson L. Dickson, Yi Xin, Mojgan Babanejad, Sevim Serley, Alex J. Chen, Bingshan Li, Lang Li, C. Michael Stein et al. · 2026 · medRxiv
  60. IL3RA identified as novel biomarker and therapeutic target for ER+ breast cancer through plasma proteome-wide mendelian randomization and TCGA database analysis
    Heting Mei, Zehan Zhang, Nan Jiang, Wenping Lü, Lei Chang, Qingya Song, Feng Li · 2026 · Clinical Proteomics
  61. Genetic Epidemiological Pipeline Identifies Candidate Markers of Clozapine-Induced Metabolic Dysfunction Revealing Potential Avenues for Precision Clozapine Prescription
    Rory Shepherd, Vijayaprakash Suppiah, Anwar Mulugeta, Scott R. Clark, Elina Hyppönen, David Stacey · 2026 · medRxiv
  62. Does hypothalamic CCN3 hypersecretion confer postpartum mood disorder risk?
    William Davies · 2026 · Translational Psychiatry
  63. Genetically prioritized mitochondrial regulators of advanced renal failure: multi-omic Mendelian randomization and biological plausibility assessment in allograft fibrosis
    Qinghuan Shen, Runmin Ding, Zhiyu Wen, Dengyuan Feng, Jianjian Zhang, Jiawen Liu, Qianguang Han, Li Sun, Hao Chen, Shuang Fei et al. · 2026 · Frontiers in Immunology
  64. Single-cell transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-mediated mechanisms and drug targets for neuropsychiatric disorders
    Honghan Zhang, Honggang Lyu, Qian Gong, Chao Wang, Qi Wang, Wei Wang, Kun Li, Zhongchun Liu · 2026 · Communications Biology
  65. Causal relationship between hypertension and epilepsy mediated by diabetic retinopathy
    junfeng zeng, Peng Jia, Ruihua Zhang, Chengwu Zhang, Li Lu, Xiaodong Liu · 2026 · Epilepsy Research
  66. Identification of DHX58 as a potential therapeutic target for ovarian cancer through multi-omics Mendelian randomization and transcriptomic data analysis
    Yanbin Chen, Fengyan Ma, Xifeng Huang, Zhemin Zhuang, Likun Lin, Yuming Liao, Jinhong Wang · 2026 · Journal of Ovarian Research
  67. NAA25 as a regulator of insulin signaling: Integration of FOXO1 imaging CRISPRi screen and Mendelian randomization
    Mengyi Zhang, Zhanwen Guan, Yanying Guo · 2026 · Life Sciences
  68. New perspectives on the mechanisms and treatment of valvular heart disease: Mendelian randomization and systematic analysis based on plasma proteins
    Cheng Wang, Xiao Shao, Jia Wang, Rui Shi, Moxuan Han, Huiyan Feng, Hezeng Dong, Tengyue Zhang, Wenqian Yang, Yue Deng · 2026 · Medicine
  69. Identification of LRP8 as a potential therapeutic target for irritable bowel syndrome from the proteomes of plasma and cerebrospinal fluid in a Mendelian randomization study
    Yudi Zhuo, Luqing Zhao, Danyan Li, Yang Ding, Nian Liu, Yichong Wang, Jixiang Liu, Chen Shen, Shengsheng Zhang · 2026 · Revista Española de Enfermedades Digestivas
  70. Common potential drug targets for ischemic stroke and coronary heart disease: CYR61, IL2RB, and ST3GAL2 are identified as key regulatory proteins
    Miao Chen, Zongni Liu, Inmaculada Xu Lou, Haitong Wan, Huifen Zhou · 2026 · International Journal of Biological Macromolecules
  71. A Flexible and Unified Framework for Single- and Multi-outcome Mendelian Randomization Using Summary Statistics
    Bo-Wei Kang, David Li, Ke Xu, Jian-Hai Chen, Si-Hao Feng, Jin-Yu Wang, G. Gao, Shinya Tasaki, Brandon L. Pierce, D. A. Bennett et al. · 2026 · American Journal of Human Genetics
  72. Plasma Proteomic Insights into the Digestive System Disorders Unveil Causal Associations and Drug Repurposing Targets
    Shixuan Zhang, Zhenqiu Liu, Dayan Sun, Fei Wu, Ye Wei, Jin Li, Shen Yang, Jinshi Huang, Jiucun Wang · 2026 · Phenomics
  73. Proteomics Signatures of Chronic Kidney Disease in Hypertension
    Yu Huang, D.W. Chen, Ziliang Ye, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Yiwei Zhang, Yiting Wu, Yuanyuan Zhang, Xianhui Qin · 2026 · Hypertension
  74. Variant‐to‐Biomarker Pathways in Peripheral Artery Disease: Multiomics Integration and Clinical Translation
    Wanting Wang, Gang Zhao, Changxin Yang, Siyao Chang · 2026 · Human Mutation
  75. A shared MHC immunogenetic signal connects aging, rheumatoid arthritis, and herpes zoster through chronic high inflammatory burden–compensatory immune tolerance dysregulation
    Xin Yao, Manli Wan · 2026 · medRxiv
  76. Integrative proteogenomic and observational analysis identifies potential biomarkers for latent autoimmune diabetes in adults
    Yuanqin Yang, Jiawen Lu, Zhenqian Wang, Tianyuan Lu, Jin Ding, Ruofan Wang, Sirui Zhou, Zhiguang Zhou, Jingyi Hu · 2026 · Cardiovascular Diabetology
  77. Single‐Cell Transcriptome‐Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes‐Related Therapeutic Targets for Obesity
    Xingjian Zhang, Yi Tian, Xiaoying Ren, Juan Tian, Jia Liu, Guang Wang · 2026 · Journal of Cellular and Molecular Medicine
  78. Integrating immune-cell transcriptomic data with Mendelian randomisation reveals novel causal genes for type 2 diabetes and its complications
    Yilan Ding, Haoyu Liu, Lei Jiang, Qian Yang, Shuangyuan Wang, Hong Lin, Mian Li, Zhiyun Zhao, T Wang, Min Xu et al. · 2026 · Diabetologia
  79. Association Between Ticagrelor and Glucose Homeostasis Regulation: Insights from Genetic and Transcriptomic Analyses
    Zhipeng Xie, Heshuo Ma, Yingjian Liu, Weihua Lai · 2026 · Biochemical Genetics
  80. Unveiling novel drug targets for atherosclerosis: A Mendelian randomization analysis
    Wenzhi Du, Dazheng Li, Na Li, Wenxiu Zhang, Jianning Wang, Tianyi Wang, Yong Zeng · 2026 · Medicine
  81. Inflammatory factors and hypertensive nephropathy: A bidirectional 2-sample Mendelian randomization study
    Yu Yang, Jianfeng Xue, L H Wang, Lei Tao, Lu Tian · 2026 · Medicine
  82. Revealing drug targets for sepsis: An association study integrating Mendelian randomization, eQTL, pQTL, and protein–protein interaction networks
    Enkui Lu, Yanan Zhang, Xuebo Shao, Junnan Chen, Mengping Jiang, Weidong Tang · 2026 · Medicine
  83. Integrative multi-omics identifies DOC2A as a novel pharmacological target for bipolar disorder
    Chengsong Yuan, Ben Zhang, Yuanyuan Liang, Junze Ran, Shiyi Hu, Andi Liu, Yuran Liu, Fengqin Qin, Lingqi Jian, Yongji He et al. · 2026 · Psychological Medicine
  84. Deciphering the RSPO3-NFATC1 switch in the bone-cartilage paradox: Genetic liability to osteoporosis protects against osteoarthritis by modulating subchondral bone compliance
    Lei Peng, Jinliang Wei, Haoran Yang, Jian Qin, Qingchu Li · 2026 · Osteoarthritis and Cartilage
  85. Identification of potential therapeutic targets for idiopathic pulmonary fibrosis: an integrated multiomics analysis
    X T Chen, Shibin Chen, Shuai Zhao, Li Y, Jingkun Chang, Si Shi, Dandan Xu, L J Li, Hong Chen · 2026 · Frontiers in Immunology
  86. The effects of plasma protein levels on the risk of endometriosis: A Mendelian randomization study
    Xiang Yao, Wenjuan Xu, Zi Wang, Qun Gao, Jianye Wang, Ping Zhou · 2026 · Medicine
  87. An integrated proteogenomic investigation of the human liver uncovers molecular drivers of steatotic liver disease
    Émilie Gobeil, Jérôme Bourgault, Malie Enault, Valérie Côté, Patricia L. Mitchell, Louis‐Jacques Ruel, Arnaud S. Girard, Marie‐Claude Vohl, Benoît J. Arsenault · 2026 · medRxiv
  88. Therapeutic targets for atherosclerotic coronary artery disease: druggable genome-wide Mendelian randomization analysis
    Wenbin Wang, Yingxian Sun, Kejia Chang, Zhenzhong Zheng · 2026 · Atherosclerosis
  89. Integrated Bioinformatics Methods Were Employed to Investigate Potential Molecular Links Between Obstructive Sleep Apnea and Sarcoidosis
    Yi Li, Chengdian Lan, Haiyan Lei, Zhi Lyu, D X Lin, Jiali Shen, Hongzhan Jiang, Yulin Wang, Congying Lu, Ying Liu · 2026 · Mediators of Inflammation
  90. Genetic evidence prioritizes circulating proteins for heart failure beyond shared BMI-related genetic liability
    Chen‐Yang Su, Tianyuan Lu · 2026 · medRxiv
  91. Cell-type-specific Mendelian randomization analysis of brain single-nucleus eQTLs and neuromyelitis optica spectrum disorder risk
    Hong Ye, Songmin Huang, Leiyun Shi, Lixiang Chai · 2026 · Multiple Sclerosis and Related Disorders
  92. A multi-omic study of plasma proteins in ankylosing spondylitis: insights from single-cell RNA sequencing and Mendelian randomization
    Ming Shao · 2026 · All Life
  93. Integrated single-cell and Mendelian randomization analyses identify aging-induced brain endothelial SPARCL1 deficiency as a key driver of vascular dementia
    Jiancheng Jin, Qiu-Han Xu, Guotao Peng, Jiankuai Zhou, Yuchun Liu, 莫君 · 2026 · Experimental Gerontology
  94. The Sex‐Stratified Effects of RSPO3 Expression on Body Fat and Blood Lipids: An Omics Mendelian Randomization Study
    Yihua Guo, Zhihe Chen, Lanhui Huang, Zhongyun Zhang, Yujia Gong, Qian Yang, Jiqiu Wang, Jie Zheng · 2026 · Obesity
  95. Mitochondrial protein alterations in vascular dementia: evidence from Mendelian randomization, transcriptomics, and a chronic hypoperfusion model
    Qian Liu, H. G. Tan, Keke Tong, Ruhai Luo, LI Hanquan, Feng Qiu, Shiliang Wang, Le Xie, Xiuli Zhang, Dahua Wu · 2026 · Frontiers in Neurology
  96. Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis
    Cyrus Ayubcha, Evan Dennis, Upasana Bhattacharyya, Jibin John, Max Lam, Todd Lencz, Tian Ge, Chia‐Yen Chen · 2026 · medRxiv
  97. Exploration of new biomarkers for rheumatoid arthritis based on plasma proteomics and transcriptome integrated with genome-wide Mendelian randomization
    Peng Zhang, Youbang Liang, Xin Li, Yihong Yang, Weidong Liang, Xueming Yao, Zhengdong Shen, Yu Wen, Chenguang Zhan, Xiaodong Wu et al. · 2026 · Journal of Autoimmunity
  98. Genetic epidemiological pipeline identifies candidate markers of clozapine-induced metabolic dysfunction: implications for precision prescribing
    Rory Shepherd, Vijayaprakash Suppiah, Anwar Mulugeta, Scott Richard Clark, Elina Hyppönen, David Stacey · 2026 · The World Journal of Biological Psychiatry
  99. Unraveling the dual role of fibroblast growth factor 5 (FGF5) in cardiorenal diseases through multi-omics causal inference
    Ting Zan, Zhiyu Wen, Hanying Jia, Xinran Dong, Ning Shen · 2026 · Cardiovascular Diabetology
  100. Genetic prioritization of HSDL2 in suicide and intentional self-harm: multi-omics evidence linking lipid metabolism and neuronal vulnerability
    Z Zhang, Yutong Wu, Fanxu Meng, Hanbing Ji, Hai Zhong, Shucheng Si, Yun WEI, Yilei Ge, Sijia Wu, Qingxin Luo et al. · 2026 · BMC Medicine