Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng, Jie, Haberland, Valeriia, Baird, Denis, Walker, Venexia, Haycock, Philip, Hurle, Mark, Gutteridge, Alex, Erola, Pau +26 more·2019·Nature Genetics
DOI 10.1101/627398
Cited by (834)
Items 301–400 of 834
- Drug repurposing opportunities for chronic kidney diseaseXiong Chen, Runnan Shen, Dongxi Zhu, Shulu Luo, Guochang You, Ruijie Li, Xiaosi Hong, Ruijun Li, Jihao Wu, Yinong Huang et al. · 2024 · iScience
- Plasma proteometabolome in lung cancer: exploring biomarkers through bidirectional Mendelian randomization and colocalization analysisBo Dong, Mengyao Wang, Kaixiu Li, Zuwei Li, Lunxu Liu, Shensi Shen · 2024 · Human Molecular Genetics
- Identification of Potential Drug Targets for Myopia Through Mendelian RandomizationYimin Qin, Chengcheng Lei, Tianfeng Lin, Xiaotong Han, Decai Wang · 2024 · Investigative Ophthalmology & Visual Science
- Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney diseasePin Zhao, Zhenhao Li, Shilong Xue, Jinshan Cui, Yonghao Zhan, Zhaowei Zhu, Xuepei Zhang · 2024 · Scientific Reports
- Mendelian Randomization Analysis Reveals Causal Effects of Plasma Proteome on Body Composition TraitsBai‐Xue Han, Shanshan Yan, Qian Xu, Jing‐Jing Ni, Xin‐Tong Wei, Gui-Juan Feng, Hong Zhang, Bin Li, Lei Zhang, Yu‐Fang Pei · 2021 · The Journal of Clinical Endocrinology & Metabolism
- Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriersEmma Louise Anderson, Dylan M. Williams, Venexia M. Walker, Neil M Davies · 2022 · Scientific Reports
- Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization studyAmy Howell, Caroline L. Relton, Richard Michael Martin, Jie Zheng, Kathreena Mary Kurian · 2023 · Scientific Reports
- Genetically Proxied Therapeutic Effect of Metformin Use, Blood Pressure, and Hypertension’s Risk: a Drug Target-Based Mendelian Randomization StudyJunhong Jiang, Di Hu, Qi Zhang, Zenan Lin, on behalf of The μ-Biomedical Data Investigation Group (Mu-BioDig) · 2023 · Journal of Cardiovascular Translational Research
- The association between ACE inhibitors and psoriasis based on the drug-targeted Mendelian randomization and real-world pharmacovigilance analysesQiubai Jin, Feihong Ren, Ping Song · 2023 · Expert Review of Clinical Pharmacology
- Potential drug targets for gastroesophageal reflux disease and Barrett’s esophagus identified through Mendelian randomization analysisYun-Lu Lin, Tao Yao, Yingwei Wang, Zhixiang Zhou, Ze‐Chao Hong, Yu Shen, Yu Yan, Yuechun Li, Jiafeng Lin · 2024 · Journal of Human Genetics
- An Analysis of Cellular Communication Network Factor Proteins as Candidate Mediators of Postpartum Psychosis RiskWilliam Davies · 2019 · Frontiers in Psychiatry
- Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanismsPietzner, Maik, Williamson, Alice, Hunt, Karen A., Koprulu, Mine, Kohleick, Leonhard, Demircan, Kamil, Genes & Health Research Team, Finer, Sarah, Zanini, Julia Carrasco, van Heel, David A et al. · 2025
- Comprehensive analysis of single-cell transcriptomics and genetic factors reveals the mechanisms and preventive strategies for the progression from pulmonary fibrosis to lung cancerJinghua Gu, Jiansheng Xu, Annan Jiao, Ningning Cai, Tianrui Gu, Pengcheng Wu, Xinyu Cheng, Bo Chen, Yang Chen, Xiaoying Liu · 2024 · International Immunopharmacology
- Mendelian randomization analysis to identify potential drug targets for osteoarthritisChenqi Lu, Yanan Xu, Shuai Chen, Li Guo, Pengcui Li, Xiaochun Wei, Xueqin Rong · 2025 · PLoS ONE
- Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer developmentJian Hui Wu, Zitong Yang, Jiafeng Ding, Sida Hao, Hong Chen, Ke Jin, Cheng Zhang, Xiangyi Zheng · 2025 · Human Genomics
- Proteome‐Wide Mendelian Randomization Identifies Candidate Causal Proteins for Cardiovascular DiseasesChen Li, Nicolas De Jay, Shanshan Zhang, Xin De Fang, Supriya Sharma, Katrina A. Catalano, Venkatesh Sridharan, Zhaoqing Wang, Lei Zhao, Joseph D. Szustakowski et al. · 2025 · Advanced Genetics
- Mendelian randomization with proxy exposures: challenges and opportunitiesIda Rahu, Ralf Tambets, Eric B. Fauman, Kaur Alasoo · 2025 · Genetics
- Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevityAna Villaplana-Velasco, Nicolas Perrot, Yu Huang, Michael Chong, Emanuele Trucco, Muthu Rama Krishnan Mookiah, Walter Nelson, Jeremy Petch, Hertzel C. Gerstein, Parminder Raina et al. · 2025 · Science Advances
- Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for CancersJie Zheng, Qian Yang, Haoyu Liu, Huiling Zhao, Shuangyuan Wang, Yi Liu, Xueyan Wu, Yilan Ding, Hui Ying, Yifan Ye et al. · 2025 · Advanced Science
- The association between plasma chemokines and breast cancer risk and prognosis: A mendelian randomization studyXingxing Yu, Yanyu Zhang, Yuxiang Lin, Shuqing Zou, Pingxiu Zhu, Mengjie Song, Fangmeng Fu, Haomin Yang · 2023 · Frontiers in Genetics
- Genetic determinants of complement activation in the general populationDamia Noce, Luisa Foco, Dorothea Orth‐Höller, Eva König, Giulia Barbieri, Maik Pietzner, Dariush Ghasemi-Semeskandeh, Stefan Coassin, Christian Fuchsberger, Martin Gögele et al. · 2023 · Cell Reports
- Integrated causal inference modeling uncovers novel causal factors and potential therapeutic targets of Qingjin Yiqi granules for chronic fatigue syndromeJunrong Li, Xiaobing Zhai, Jixing Liu, Chi Kin Lam, Weiyu Meng, Yuefei Wang, Shu Li, Yapeng Wang, Kefeng Li · 2024 · Acupuncture and Herbal Medicine
- Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomicsSui Deng, Rui Mao, Yifeng He · 2024 · Frontiers in Immunology
- Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblastsYi Wang, Guihua Chen, Li Deng · 2024 · Biology Direct
- Integrative Proteogenomic Analyses Provide Novel Interpretations of Type 1 Diabetes Risk Loci Through Circulating ProteinsTianyuan Lu, Despoina Manousaki, Lei Sun, Andrew D. Paterson · 2025 · Diabetes
- Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ OphthalmopathyChenxin Ke, Yuefeng Yu, Jiang Li, Yuetian Yu, Ying Sun, Yuying Wang, Bin Wang, Yingli Lu, Mengjun Tang, Ningjian Wang et al. · 2025 · ImmunoTargets and Therapy
- Common Regulatory Mechanisms Mediated by Cuproptosis Genes in Inflammatory Bowel Disease and Major Depressive DisorderJisen Shi, Qianyi Wu, Mengmeng Sang, Liming Mao · 2025 · Genes
- Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization studyXin Huang, Jie V. Zhao · 2025 · BMC Medicine
- Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI WorkshopMatthew Gregory Nayor, Li Shen, Gary Matthew Hunninghake, Peter Kochunov, R. Graham Barr, David A. Bluemke, Ulrich Broeckel, Peter D. Caravan, Susan C. Cheng, Paul S. de Vries et al. · 2021 · Circulation Cardiovascular Imaging
- Genetic control of body weight by the human brain proteomeÉloi Gagnon, Arnaud S. Girard, Émilie Gobeil, Jérôme Bourgault, Christian Yves Couture, Patricia L. Mitchell, Claude Bouchard, Angelo Tremblay, Patrick Mathieu, Andréanne Michaud et al. · 2023 · iScience
- Potential therapeutic targets for membranous nephropathy: proteome-wide Mendelian randomization and colocalization analysisZhihang Su, Qijun Wan · 2024 · Frontiers in Immunology
- Proteomic analysis reveals potential therapeutic targets for childhood asthma through Mendelian randomizationYiqing Wu, Yixin Cai, Xiaoli Chen, Shang‐Qin Chen, Xiu‐Feng Huang, Zhenlang Lin · 2024 · Clinical and Translational Allergy
- Exploration of potential novel drug targets for diabetic retinopathy by plasma proteome screeningWeichen Yuan, Wei Xu, Xin Xu, Bo Qu, Fangkun Zhao · 2024 · Scientific Reports
- Integrative Post-Genome-Wide Association Study Analyses Relevant to Psychiatric Disorders: Imputing Transcriptome and Proteome SignalsHüseyin Gedik, Roseann Elizabeth Peterson, Brien P. Riley, Vladimir I. Vladimirov, Silviu‐Alin Bacanu · 2023 · Complex Psychiatry
- Correspondence on ‘Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study‘Ran Cui, Qiang Tong, Zhiyong Chen, Miao Chen, Sheng‐Ming Dai · 2020 · Annals of the Rheumatic Diseases
- Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsMaría Gordillo‐Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Juan Pablo Casas, Nish Chaturvedi, Olia Papacosta et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisationMatthew Lyon, Louise A C Millard, George Davey Smith, Tom R. Gaunt, Kate M. Tilling · 2022 · medRxiv
- Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteinsMohd Anisul Karim, Bruno Ariano, Jeremy Schwartzentruber, Juan María Roldán‐Romero, Edward Mountjoy, James D. Hayhurst, Annalisa Buniello, Elmutaz Shaikho Elhaj Mohammed, Miguel Carmona, Michael Vaclav Holmes et al. · 2023 · medRxiv
- An accurate genetic colocalization method for the HLA locusGuillaume Butler‐Laporte, Tianyuan Lu, Sam Morris, Wenmin Zhang, Gavin Band, Fergus Hamilton, Amanda Yoon-Yee Chong, Kuang Lin, Ruth Nanjala, John Brent Richards et al. · 2024 · medRxiv
- Gene discovery and pleiotropic architecture of Chronic Pain in a Genome-wide Association Study of >1.2 million IndividualsSylvanus Toikumo, Christal N. Davis, Zeal Jinwala, Yousef Khan, Mariela V. Jennings, Lea Karatheodoris Davis, Sandra Sanchez‐Roige, Rachel L. Kember, Henry R. Kranzler · 2025 · medRxiv
- Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for EndometriosisMingrui Zou, Mingmei Lin, Kai-Lun Hu, Rong Li · 2024 · Biology
- PSMB4: a potential biomarker and therapeutic target for depression, perspective from integration analysis of depression GWAS data and human plasma proteomeJie-Wei Liu · 2025 · Translational Psychiatry
- Association of Plasma Angiogenin With Risk of Incident End-Stage Kidney Disease in Individuals With Type 2 DiabetesResham L Gurung, Jianjun Liu, Sylvia Liu, Janus Lee, Huili Zheng, Clara Chan, Keven Ang, Su Chi Lim · 2025 · Diabetes
- Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for PsoriasisHesong Wang, Chenguang Wang, Ruihao Qin, Jia He, Xuan Zhang, Chenjing Ma, Li Shi, Lijun Fan, Liuying Wang, Lei Cao · 2025 · Biomedicines
- Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysisJinrui Li, Kai Yu, Fan Bu, Peng Li, Lei Hao · 2025 · Nutrition Journal
- Circulating Protein Mediators Linking Genetically Predicted Smoking to Abdominal Aortic Aneurysm: A Genomic-Proteomic AnalysisShuai Yuan, Samuel Khodursky, Jiawei Geng, Pranav Sharma, Joshua Michael Spin, Philip S. Tsao, Michael G. Levin, Scott M. Damrauer · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
- Integrating multi-modal omics to identify therapeutic atherosclerosis pathways for coronary heart diseaseSophie C. de Ruiter, Marion van Vugt, Chris Finan, Diederick E. Grobbee, Dominique P.V. de Kleijn, Gerard Pasterkamp, Hester M. den Ruijter, Ernest Diez Benavente, Sanne A. E. Peters, Amand Floriaan Schmidt · 2025 · EBioMedicine
- From plasma proteomics Mendelian Randomization to neuropathological validation: The potential role of CTSH-GRN-TMEM106B and TREM2-IL-34 networks of microglia in Alzheimer's disease.Yu-Hao Yuan, Shengnan Wang, Piao-Piao Lian, Zhong-Hao Yu, Xiang-Ting Gao, Yi-Jie Duan, Ling Mao, Yi-Wu Zhou · 2025 · European Journal of Pharmacology
- Multi-omics signatures of chronic inflammation across immune-related disease statesHui Li, Xiaolin Xie, Lirui Tang, Chuanben Chen, Jinluan Li · 2026 · Frontiers in Immunology
- Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease riskMaik Pietzner, Alice Williamson, Karen A. Hunt, Mine Koprulu, Leonhard Kohleick, Kamil Demircan, David A. van Heel, Sarah Finer, Julia Carrasco-Zanini, David A. van Heel et al. · 2026 · Nature Genetics
- Exploration of potential drug targets for Glaucoma by plasma proteome screeningZhiqi Wang, Huanyu Zhou, Fei Wang, Haishan Huang · 2024 · Journal of Proteomics
- Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization StudyJun Wu, Jue Xu, Hao‐qi Zou, Yi‐jiang Ouyang, Shang‐jie Li, Liang Wu, Jie Zhang, Mingjuan Yin, Dong‐Qing Ye, Jindong Ni · 2024 · Journal of Cachexia Sarcopenia and Muscle
- Machine learning reveals connections between preclinical type 2 diabetes subtypes and brain healthYi Fan, Jing Yuan, Fei Han, Judith Somekh, Mor Peleg B, Fei Ling Wu, Zhilong Jia, Yi‐Cheng Zhu, Zhengxing Huang · 2025 · Brain
- (Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery DiseaseYingmei Li, Sihan Wang, Ling Liu, Hao Cai, Yacan Huang, Mingjing Gao, Xiaogang Zhang, Qingqing Wu, Gaokun Qiu · 2025 · Advanced Science
- Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysisZhonghua Xiong, Zhi Kai Guo, Lei Zhao, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Geyu Liu, Tianshuang Gao et al. · 2025 · The Journal of Headache and Pain
- Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomizationYu-Xuan Yao, Chen Tang, Feng‐Lei Si, Jicheng Lv, Su-Fang Shi, Shu‐Feng Zhou, Lijun Liu, Hong Zhang · 2025 · Renal Failure
- Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genesEmma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xue Min Wang, Pik Fang Kho, Danny Legge, Andrei‐Emil Constantinescu, Matthew A. Lee, David Timothy Bishop, Andrew Tan Chan et al. · 2025 · Nature Communications
- Elucidation of disease etiology by trans-layer omics analysisYuya Shirai, Yukinori Okada · 2021 · Inflammation and Regeneration
- Integrated untargeted and targeted proteomics to unveil plasma prognostic markers for patients with acute paraquat poisoning: A pilot studyTianqi Zhang, Siqi Huang, Min Wang, Na Yang, Huaijun Zhu · 2023 · Food and Chemical Toxicology
- Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes.Tingting Jia, Tian-Cheng Liu, Shiyi Hu, Yongjun Li, Peixin Chen, Fengqin Qin, Yongji He, Feng Han, Cheng-Cheng Zhang · 2024 · Psychological Medicine
- Novel Protein Biomarkers and Therapeutic Targets for Type 1 Diabetes and Its Complications: Insights from Summary-Data-Based Mendelian Randomization and Colocalization AnalysisMingrui Zou, Jichun Yang · 2024 · Pharmaceuticals
- Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization studyYuan Gao, Youtao Zhou, Zikai Lin, Fengzhen Chen, Haiyang Wu, Chusheng Peng, Yingying Xie · 2024 · Clinical Rheumatology
- Unveiling Novel Protein Biomarkers for Psoriasis Through Integrated Analysis of Human Plasma Proteomics and Mendelian RandomizationRui Mao, Tongtong Zhang, Ziye Yang, Ji Li · 2024 · Psoriasis Targets and Therapy
- Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancersMasahiro Yoshikawa, Tomohiro Nakayama, Kensuke Asaba · 2024 · Communications Biology
- Genetic evidence for the causal association between programmed death-ligand 1 and lung cancerZhao Yang, Rong Yu, Wei Deng, Weihu Wang · 2021 · Journal of Cancer Research and Clinical Oncology
- Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organsJulian Willett, Tianyuan Lu, Tomoko Nakanishi, Satoshi Yoshiji, Guillaume Butler‐Laporte, Sirui Zhou, Yossi Farjoun, John Brent Richards · 2023 · Human Genetics
- Realising the full potential of MR-PHeWAS in cancerJack Bowden · 2020 · British Journal of Cancer
- COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysisSatoshi Yoshiji, Tianyuan Lu, Guillaume Butler‐Laporte, Julia Carrasco-Zanini, Yiheng Chen, Kevin Y. H. Liang, Julian Willett, Chen‐Yang Su, Shidong Wang, Darin Adra et al. · 2023 · medRxiv
- Cohort Profile: The Mendelian Randomization in Pregnancy (MR-PREG) collaboration - Improving evidence for prevention and treatment of adverse pregnancy and perinatal outcomesNancy McBride, Gemma Clayton, Ana Gonçalves Soares, Qian Yang, Tom A. Bond, Amy E. Taylor, Charikleia Chatzigeorgiou, Elisabeth Aiton, Jane West, Maria Christine Magnus et al. · 2025 · medRxiv
- An Introduction to Causal Inference Methods with Multi‐omics DataMinhao Yao, Zhonghua Liu · 2025 · Current Protocols
- UK Biobank: Transforming drug discovery and precision medicineJelena Bešević, Saredo Said, Réka Nagy, Yalda Jamshidi, Christopher D. Whelan, Lauren Carson, Martin K. Rutter, Adam J. Lewandowski, Mark Effingham, Rory Collins et al. · 2025 · British Journal of Pharmacology
- Revealing the genetic architectures underlying organ-specific aging based on proteomic dataRen‐Jie Zhu, Yan Guo, Jiahao Wang, Ke Yu, Wei Shi, Wen Pan, Xian-lin Yu, Wei Chen, Shan‐Shan Dong, Tie‐Lin Yang · 2025 · Nature Communications
- Plasma proteomics and incident coronary heart diseaseMatthew P. Huber, Jennifer A. Brody, Colleen M. Sitlani, Thomas R. Austin, Usman A. Tahir, Shuliang Deng, Devendra Meena, JINGSHA CHEN, Kunihiro Matsushita, Christie Mitchell Ballantyne et al. · 2026 · Communications Medicine
- Uncovering Druggable Targets in Aortic Dissection: An Association Study Integrating Mendelian Randomization, pQTL, and Protein–Protein Interaction NetworkDaisong Jiang, Sihao Zheng, Xiaokang Xu, Honghua Yue, Weitao Liang, Zhong Wu · 2024 · Biomedicines
- Therapeutic targets for gastrointestinal diseases: proteome-wide Mendelian randomization and colocalization analysesDaqin Zhan, Zhihao Yang, Pengcheng Li, Jun Pan · 2024 · Postgraduate Medical Journal
- Evaluating the Causal Effect of Circulating Proteome on Glycemic Traits: Evidence From Mendelian RandomizationXing Xing, Siqi Xu, Yining Wang, Ziyuan Shen, Simin Wen, Yan Zhang, Guangfeng Ruan, Guoqi Cai · 2024 · Diabetes
- GNLY as A Novel Cis-eQTL and Cis-pQTL Mediated Susceptibility Gene in Suppressing Prostatitis. Mendelian Randomization StudyYi Wang, Hao Ji, Guihua Chen, Jianhua Zhou, Dongliang Zhang, Xiang Wang · 2024 · Archives of Medical Research
- Mendelian Randomization Estimates the Effects of Plasma and Cerebrospinal Fluid Proteins on Intelligence, Fluid Intelligence Score, and Cognitive PerformanceWei Zhao, Xinyu Zhang, Feng Li, Yan Cheng · 2024 · Molecular Neurobiology
- Proteome-wide mendelian randomization identifies causal plasma proteins in interstitial lung diseaseKunrong Yu, Wanying Li, Wenjie Long, Yijia Li, Yanting Li, Huili Liao, Jianhong Liu · 2025 · Scientific Reports
- Identification of potential druggable targets for endometriosis through Mendelian randomization analysisPeng Chen, Xin Chuan Wei, Xiaoke Li, Yihang Zhou, Qifang Liu, Ling Ouyang · 2025 · Frontiers in Endocrinology
- Integrated Single‐Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney DiseaseXinhui Huang, Cheng Gang Zhu, Shiqi Lv, Yulin Wang, Jiayi Wang, Shuangxin Yuan, Yue Yang, Xiaoqiang Ding, Xiaoyan Zhang · 2025 · The Journal of Gene Medicine
- Leveraging Proteomics and Proteogenomics for Understanding Osteoporosis and Other Musculoskeletal DiseasesM. Hasebe, C. Su, D. Kiel, Satoshi Yoshiji · 2025 · Current Osteoporosis Reports
- Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targetsKaixi Ding, Juejue Zhangwang, Ming Lei, Chunping Xiong · 2024 · BMC Genomics
- ENPP2 /Autotaxin: The potential drug target for alcoholic liver disease identified through Mendelian randomization analysisPeiqiong Luo, Xuefeng Yu · 2024 · Liver International
- Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analysesMin Cao, Bin Cui · 2024 · Cardiovascular Diabetology
- Identification of potential drug targets for insomnia by Mendelian randomization analysis based on plasma proteomicsNi Yang, Liangyuan Shi, Pengfei Xu, Fang Ren, Shimeng Lv, Chunlin Li, Xianghua Qi · 2024 · Frontiers in Neurology
- Leveraging pQTL-based Mendelian randomization to identify new treatment prospects for primary biliary cholangitis and primary sclerosing cholangitisLei Dai, Yunyan Ye, Joseph Mugaanyi, Zetong Hu, Jing Li Huang, Changjiang Lu · 2024 · Aging
- Genetic association of glycemic traits and antihyperglycemic agent target genes with the risk of lung cancer: A Mendelian randomization studyWen Juan Sun, Xiaoyu Zhang, Ning Li, Yan He, Jianguang Ji, Deqiang Zheng · 2024 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
- Causal Relationship Between Circulating Immune Cells and Recurrent Spontaneous Abortion: A Bidirectional Mendelian Randomization StudyHailin Yu, Xianyang Hu, Xixi Huang, Tingxuan Yin, Lu Liu, Chaoyan Yue, Meirong Du · 2024 · American Journal of Reproductive Immunology
- Identification of Novel Protein Biomarkers and Drug Targets for Acne Vulgaris by Integrating Human Plasma Proteome with Genome-Wide Association DataDongrui Xu, Xiaoyi Yang, Wenjuan Wu, Jiankang Yang · 2024 · Journal of Inflammation Research
- Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analysesShuai-Kang Wang, Qijun Wang, Xuan Zhao, Peng Wang, Xiangyu Li, Wei Wang, Shibao Lu · 2024 · The journal of nutrition health & aging
- Using proteomics to identify the mechanisms underlying the benefits of statins on ischemic heart diseaseJie V. Zhao, Junmeng Zhang · 2024 · npj Cardiovascular Health
- Understanding the Genetic Architecture of Vitamin Status Biomarkers in the Genome-Wide Association Study Era: Biological Insights and Clinical SignificanceWilliam R. Reay, Erin D. Clarke, Clara Albiñana, Liang‐Dar Hwang · 2024 · Advances in Nutrition
- Proteome-Wide Mendelian Randomization Analysis to Identify Potential Plasma Biomarkers and Therapeutic Targets for Epithelial Ovarian Cancer SubtypesQianhan Lin, Jiajia Li, Yating Sun, Zulimire Abudousalamu, Mengyang Xue, Liangqing Yao, Mo Chen · 2024 · International Journal of Women s Health
- Potential drug targets for asthma identified through mendelian randomization analysisXingxuan Chen, Yu Shang, Danting Shen, Si Shi, Zhe Wen, Lijuan Li, Hong Chen · 2025 · Respiratory Research
- Potential biomarkers for predicting the risk of thyroid cancer in immunosenescence: a population-based and externally validated multi omics studyQian Li, Yuanyuan Zhao, Jiawei Yan, Chao He · 2025 · Frontiers in Oncology
- Seronegative Sicca Syndrome: Diagnostic Considerations and Management StrategiesYordanka Mincheva Basheva-Kraeva, Krasimir Iliev Kraev, Petar Angelov Uchikov, Maria Ilieva Kraeva, Bozhidar Krasimirov Hristov, Nina Staneva Stoyanova, Vesela Todorova Mitkova-Hristova, Borislav Ivanov, Stanislav S. Karamitev, Nina Koleva et al. · 2025 · Life
- Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremitiesAlexandra S. Shadrina, Elizaveta E. Elgaeva, Ian B. Stanaway, Gail Pairitz Jarvik, Bahram Namjou, Wei‐Qi Wei, Joe Glessner, Hakon H. Hakonarson, Pradeep Suri, Yakov A. Tsepilov · 2022 · PLoS ONE
- Mendelian randomization: using genetic information in epidemiological studies (review)Denis Plotnikov · 2023 · RESEARCH RESULTS IN BIOMEDICINE
- Screening Plasma Proteins for the Putative Drug Targets for Carpal Tunnel SyndromeBai‐Xue Han, Tian-Ye Huang, Qi‐Gang Zhao, Shanshan Yan, Qian Xu, Xin-Ling Ma, Yuan Luo, Yu‐Fang Pei · 2023 · Cellular and Molecular Neurobiology