The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Posttranslational Modification of p53: Cooperative Integrators of Function
Open accessAbstract
The p53 protein is modified by as many as 50 individual posttranslational modifications. Many of these occur in response to genotoxic or nongenotoxic stresses and show interdependence, such that one or more modifications can nucleate subsequent events. This interdependent nature suggests a pathway that operates through multiple cooperative events as opposed to distinct functions for individual, isolated modifications. This concept, supported by recent investigations, which provide exquisite detail as to how various modifications mediate precise protein-protein interactions in a cooperative manner, may explain why knockin mice expressing p53 proteins substituted at one or just a few sites of modification typically show only subtle effects on p53 function. The present article focuses on recent, exciting progress and develops the idea that the impact of modification on p53 function is achieved through collective and integrated events.
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Citations
Cites
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BackgroundAcetylation and deacetylation of non-histone proteins
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DNA damage activates p53 through a phosphorylation–acetylation cascade
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Self-citation
Cited by
The growing landscape of lysine acetylation links metabolism and cell signalling
Choudhary, C., Weinert, B. T., Nishida, Y., Verdin, E., & Mann, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3841 · Cited by 1,324
Regulating tumor suppressor genes: post-translational modifications
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p53 modifications: exquisite decorations of the powerful guardian
Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz060 · Cited by 392
DNA damage-how and why we age?
Yousefzadeh, M., Henpita, C., Vyas, R., Soto-Palma, C., Robbins, P., & Niedernhofer, L. (2021) · eLife · doi:10.7554/elife.62852 · Cited by 399
Pejaver, V., Hsu, W., Xin, F., Dunker, A. K., Uversky, V. N., & Radivojac, P. (2014) · Protein Science · doi:10.1002/pro.2494 · Cited by 349
Metadata
- Authors
- Meek, D. W., & Anderson, C. W.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-28
- Volume
- 1
- Issue
- 6
- Pages
- a000950-a000950
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2107739085
- Cited by
- 483
- References
- 24
- Type
- posted content
- Language
- en
- Open access
- bronze
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