The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development
Open accessAbstract
Properly regulated intercellular adhesion is critical for normal development of all metazoan organisms. Adherens junctions play an especially prominent role in development because they link the adhesive function of cadherin-catenin protein complexes to the dynamic forces of the actin cytoskeleton, which helps to orchestrate a spatially confined and very dynamic assembly of intercellular connections. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are linked to several major developmental signaling pathways crucial for normal morphogenesis. In this article we will highlight the key genetic studies that uncovered the role of cadherin-catenin proteins in vertebrate development and discuss the potential role of these proteins as molecular biosensors of external cellular microenvironment that may spatially confine signaling molecules and polarity cues to orchestrate cellular behavior throughout the complex process of normal morphogenesis.
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Cites
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930
Tight junctions/adherens junctions: basic structure and function
Niessen, C. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700865 · Cited by 756
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510
E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
Tunggal, J. A., Helfrich, I., Schmitz, A., Schwarz, H., Günzel, D., Fromm, M., Kemler, R., Krieg, T., & Niessen, C. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600605 · Cited by 491 · cited 2×
“Intriguingly, however, deletion of E-cadherin in embryonic skin epidermis did not result in a significant impairment of AJs, most likely because of compensatory up-regulation of P-cadherin (Young et al. 2003; Tinkle et al. 2004; Tunggal et al. 2005).”
BackgroundQian, X., Karpova, T., Sheppard, A. M., McNally, J., & Lowy, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600136 · Cited by 396
Tinkle, C. L., Lechler, T., Pasolli, H. A., & Fuchs, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307437100 · Cited by 193
E‐cadherin controls adherens junctions in the epidermis and the renewal of hair follicles
Young, P., Boussadia, O., Halfter, H., Grose, R., Berger, P., Leone, D. P., Robenek, H., Charnay, P., Kemler, R., & Suter, U. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg560 · Cited by 156
Cited by
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036
Self-citationAdherens Junction: Molecular Architecture and Regulation
Meng, W., & Takeichi, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002899 · Cited by 593
Structure and Biochemistry of Cadherins and Catenins
Shapiro, L., & Weis, W. I. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003053 · Cited by 462
Control of cellular responses to mechanical cues through YAP/TAZ regulation
Dasgupta, I., & McCollum, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007963 · Cited by 360
Metadata
- Authors
- Stepniak, E., Radice, G. L., & Vasioukhin, V.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-08-26
- Volume
- 1
- Issue
- 5
- Pages
- a002949-a002949
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2126622935
- Cited by
- 167
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Stepniak, E., Radice, G. L., & Vasioukhin, V. (2009). Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a002949
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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