Spliceosome Structure and Function

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040

Mechanisms of Alternative Pre-Messenger RNA Splicing

Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665

Expansion of the eukaryotic proteome by alternative splicing

Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,254

Understanding alternative splicing: towards a cellular code

Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284

An extensive network of coupling among gene expression machines

Maniatis, T., & Reed, R. (2002) · Nature · doi:10.1038/416499a · Cited by 1,148

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

Staley, J. P., & Guthrie, C. (1998) · Cell · doi:10.1016/s0092-8674(00)80925-3 · Cited by 1,133

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

Wang, Z., & Burge, C. B. (2008) · RNA · doi:10.1261/rna.876308 · Cited by 1,127

Exon Recognition in Vertebrate Splicing

Berget, S. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2411 · Cited by 1,090

Pre-mRNA Splicing

Jurica, M. S., & Moore, M. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00270-3 · Cited by 963

Alternative pre-mRNA splicing: the logic of combinatorial control

Smith, C. W. J., & Valcárcel, J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01604-2 · Cited by 901

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

Oubridge, C., Ito, N., Evans, P. R., Teo, C.-H., & Nagai, K. (1994) · Nature · doi:10.1038/372432a0 · Cited by 832

GraFix: sample preparation for single-particle electron cryomicroscopy

Kastner, B., Fischer, N., Golas, M. M., Sander, B. O., Dube, P., Boehringer, D., Hartmuth, K., Deckert, J., Hauer, F., Wolf, E., et al. (2007) · Nature Methods · doi:10.1038/nmeth1139 · Cited by 578

How did alternative splicing evolve?

Ast, G. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1451 · Cited by 544

20 Splicing of Precursors to mRNAs by the Spliceosomes

Burge, C. B., Tuschl, T., & Sharp, P. A. (1999) · doi:10.1101/087969589.37.525 · Cited by 538

Crystal Structure of a Self-Spliced Group II Intron

Toor, N., Keating, K. S., Taylor, S. D., & Pyle, A. M. (2008) · Science · doi:10.1126/science.1153803 · Cited by 498

Splicing double: insights from the second spliceosome

Patel, A. A., & STEITZ, J. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1259 · Cited by 479

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

Madhani, H. D., & Guthrie, C. (1992) · Cell · doi:10.1016/0092-8674(92)90556-r · Cited by 438

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

Webby, C. J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B. M., Nielsen, M. L., Schmitz, C., Butler, D. S., Yates, J. R., et al. (2009) · Science · doi:10.1126/science.1175865 · Cited by 423

Intron—exon structures of eukaryotic model organisms

Long, M., & Deutsch, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.3219 · Cited by 417

The pathobiology of splicing

Ward, A. J., & Cooper, T. A. (2009) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 415

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

Clark, T. A., Sugnet, C. W., & Ares, M. (2002) · Science · doi:10.1126/science.1069415 · Cited by 411

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.Preprint

Xiao, S.-H., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.3.334 · Cited by 397

Isolation of an active step I spliceosome and composition of its RNP core

Bessonov, S., Anokhina, M. M., Will, C. L., Urlaub, H., & Lührmann, R. (2008) · Nature · doi:10.1038/nature06842 · Cited by 396

Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs

Kambach, C., Walke, S., Young, R., Avis, J. M., de la Fortelle, E., Raker, V. A., Lührmann, R., Li, J., & Nagai, K. (1999) · Cell · doi:10.1016/s0092-8674(00)80550-4 · Cited by 387

Prp8 protein: At the heart of the spliceosome

Grainger, R. J. R., & Beggs, J. D. (2005) · RNA · doi:10.1261/rna.2220705 · Cited by 374

Allosteric Cascade of Spliceosome Activation

Brow, D. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.043002.091635 · Cited by 372

Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

Krummel, D. P., Oubridge, C., Leung, A. K.-W., Li, J., & Nagai, K. (2009) · Nature · doi:10.1038/nature07851 · Cited by 358

Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA

Price, S. R., Evans, P. R., & Nagai, K. (1998) · Nature · doi:10.1038/29234 · Cited by 356

An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p

Staley, J. P., & Guthrie, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80174-4 · Cited by 339

The Prp19p-Associated Complex in Spliceosome Activation

Chan, S., Kao, D.-I., Tsai, W.-Y., & Cheng, S.-C. (2003) · Science · doi:10.1126/science.1086602 · Cited by 323

The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome

Fabrizio, P., Dannenberg, J., Dube, P., Kastner, B., Stark, H., Urlaub, H., & Lührmann, R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.040 · Cited by 313

13 Splicing of Precursors to mRNA by the SpliceosomePreprint

Moore, M. J., Query, C. C., & Sharp, P. A. (1993) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969380.24.303 · Cited by 309

Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions

Deckert, J., Hartmuth, K., Boehringer, D., Behzadnia, N., Will, C. L., Kastner, B., Stark, H., Urlaub, H., & Lührmann, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00582-06 · Cited by 301

Crystal Structure of the Spliceosomal 15.5kD Protein Bound to a U4 snRNA Fragment

Vidovic, I., Nottrott, S., Hartmuth, K., Lührmann, R., & Ficner, R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00131-3 · Cited by 298

Identification of alternative splicing regulators by RNA interference in Drosophila

Park, J. W., Parisky, K. M., Celotto, A. M., Reenan, R. A., & Graveley, B. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407004101 · Cited by 290

Interaction of U2AF 65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

Valcárcel, J., Gaur, R. K., Singh, R., & Green, M. R. (1996) · Science · doi:10.1126/science.273.5282.1706 · Cited by 288

Molecular Architecture of the Multiprotein Splicing Factor SF3b

Golas, M. M., Sander, B. O., Will, C. L., Lührmann, R., & Stark, H. (2003) · Science · doi:10.1126/science.1084155 · Cited by 277

Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP

Stevens, S. W., Ryan, D. E., Ge, H. Y., Moore, R. E., Young, M. K., Lee, T. D., & Abelson, J. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00436-7 · Cited by 273

The architecture of pre-mRNAs affects mechanisms of splice-site pairing

Fox-Walsh, K. L., Dou, Y., Lam, B. J., Hung, S., Baldi, P., & Hertel, K. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508489102 · Cited by 267

Mechanisms of fidelity in pre-mRNA splicing

Reed, R. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00097-1 · Cited by 253

Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

Stark, H., Dube, P., Lührmann, R., & Kastner, B. (2001) · Nature · doi:10.1038/35054102 · Cited by 253

Structural Basis for Recognition of the Intron Branch Site RNA by Splicing Factor 1

Liu, Z., Luyten, I., Bottomley, M. J., Messias, A. C., Houngninou-Molango, S., Sprangers, R., Zanier, K., Krämer, A., & Sattler, M. (2001) · Science · doi:10.1126/science.1064719 · Cited by 244

Splicing-related catalysis by protein-free snRNAs

Valadkhan, S., & Manley, J. L. (2001) · Nature · doi:10.1038/35099500 · Cited by 222

Composition and three‐dimensional EM structure of double affinity‐purified, human prespliceosomal A complexes

Behzadnia, N., Golas, M. M., Hartmuth, K., Sander, B. O., Kastner, B., Deckert, J., Dube, P., Will, C. L., Urlaub, H., Stark, H., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601631 · Cited by 218

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.Preprint

Hoffman, B. E., & Grabowski, P. J. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2554 · Cited by 215

Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF65 and SF1/mBBP

Selenko, P., Gregorovic, G., Sprangers, R., Stier, G., Rhani, Z., Krämer, A., & Sattler, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00115-1 · Cited by 212

Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for Sub2, an essential spliceosomal ATPasePreprint

Kistler, A. L. (2001) · Genes & Development · doi:10.1101/gad.851301 · Cited by 207

A Novel Peptide Recognition Mode Revealed by the X-Ray Structure of a Core U2AF35/U2AF65 Heterodimer

Kielkopf, C. L., Rodionova, N. A., Green, M. R., & Burley, S. K. (2001) · Cell · doi:10.1016/s0092-8674(01)00480-9 · Cited by 203

Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Pleiss, J. A., Whitworth, G. B., Bergkessel, M., & Guthrie, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050090 · Cited by 199

A Pathway of Sequential Arginine-Serine-Rich Domain-Splicing Signal Interactions during Mammalian Spliceosome Assembly

Shen, H., & Green, M. R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.021 · Cited by 199

Specific Alterations of U1-C Protein or U1 Small Nuclear RNA Can Eliminate the Requirement of Prp28p, an Essential DEAD Box Splicing Factor

Chen, J. Y., Stands, L., Staley, J. P., Jackups, R., Latus, L. J., & Chang, T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00170-8 · Cited by 199

The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase

Small, E. C., Leggett, S. R., Winans, A. A., & Staley, J. P. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.043 · Cited by 194

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing.Preprint

Sun, J., & Manley, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.7.843 · Cited by 193

Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

Cao, W., Jamison, S. F., & García-Blanco, M. A. (1997) · PubMed · Cited by 193

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysisPreprint

Wang, C., Chua, K. F., Seghezzi, W., Lees, E. M., Gozani, O., & Reed, R. (1998) · Genes & Development · doi:10.1101/gad.12.10.1409 · Cited by 187

Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

Sickmier, E. A., Frato, K. E., Shen, H., Paranawithana, S. R., Green, M. R., & Kielkopf, C. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.025 · Cited by 187

Exon ligation is proofread by the DExD/H-box ATPase Prp22p

Mayas, R. M., Maita, H., & Staley, J. P. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1093 · Cited by 183

A mechanism to enhance mRNA splicing fidelity: The RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates

Burgess, S. M., & Guthrie, C. (1993) · Cell · doi:10.1016/0092-8674(93)90363-u · Cited by 178

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

Sharma, S., Kohlstaedt, L. A., Damianov, A., Rio, D. C., & Black, D. L. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1375 · Cited by 177

RBM5/Luca-15/H37 Regulates Fas Alternative Splice Site Pairing after Exon Definition

Bonnal, S., Martínez, C., Förch, P., Bachi, A., Wilm, M. S., & Valcárcel, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.008 · Cited by 176

Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes

Herold, N., Will, C. L., Wolf, E., Kastner, B., Urlaub, H., & Lührmann, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-08 · Cited by 176

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2Preprint

Tsai, R.-T., Fu, R., Yeh, F.-L., Tseng, C. K., Lin, Y. J., Huang, Y.-H., & Cheng, S.-C. (2005) · Genes & Development · doi:10.1101/gad.1377405 · Cited by 173

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

Warkocki, Z., Odenwälder, P., Schmitzová, J., Platzmann, F., Stark, H., Urlaub, H., Ficner, R., Fabrizio, P., & Lührmann, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1729 · Cited by 172

Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosomePreprint

Tanaka, N., Aronova, A., & Schwer, B. (2007) · Genes & Development · doi:10.1101/gad.1580507 · Cited by 159

Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines

Staley, J. P., & Woolford, J. L. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.003 · Cited by 157

RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humansPreprint

Shen, H., & Green, M. R. (2006) · Genes & Development · doi:10.1101/gad.1422106 · Cited by 153

Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles

Kambach, C., Walket, S., & Nagai, K. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)80032-3 · Cited by 151

Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

Tazi, J., Kornstädt, U., Rossi, F., Jeanteur, P., Cathala, G., Brunel, C., & Lührmann, R. (1993) · Nature · doi:10.1038/363283a0 · Cited by 149

“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing

Smith, D. J., Query, C. C., & Konarska, M. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.013 · Cited by 149

Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP

Liu, S., Li, P., Dybkov, O., Nottrott, S., Hartmuth, K., Lührmann, R., Carlomagno, T., & Wahl, M. C. (2007) · Science · doi:10.1126/science.1137924 · Cited by 149

snRNAs as the catalysts of pre-mRNA splicing

Valadkhan, S. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.10.008 · Cited by 147

The second catalytic step of pre-mRNA splicing.

Umen, J., & Guthrie, C. (1995) · PubMed · Cited by 145

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

Mathew, R. S., Hartmuth, K., Möhlmann, S., Urlaub, H., Ficner, R., & Lührmann, R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1415 · Cited by 145

Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants

Query, C. C., & Konarska, M. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00217-5 · Cited by 144

A structural analysis of the group II intron active site and implications for the spliceosome

Keating, K. S., Toor, N., Perlman, P. S., & Pyle, A. M. (2009) · RNA · doi:10.1261/rna.1791310 · Cited by 143

U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction

Sashital, D. G., Cornilescu, G., & Butcher, S. E. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb863 · Cited by 139

13 Spliceosome Structure and FunctionPreprint

Will, C. L., & Lührmann, R. (2006) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969739.43.369 · Cited by 138

A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

Schwer, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.003 · Cited by 136

RNA-RNA Interactions in Nuclear Pre-mRNA SplicingPreprint

Nilsen, T. W. (1998) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969509.35.279 · Cited by 135

A role for ubiquitin in the spliceosome assembly pathway

Bellare, P., Small, E. C., Huang, X., Wohlschlegel, J. A., Staley, J. P., & Sontheimer, E. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1401 · Cited by 134

Self-splicing group II and nuclear pre-mRNA introns: how similar are they?

Jacquier, A. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90075-m · Cited by 132

Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa

Peña, V., Liu, S., Bujnicki, J. M., Lührmann, R., & Wahl, M. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.023 · Cited by 132

PP1/PP2A Phosphatases Are Required for the Second Step of Pre-mRNA Splicing and Target Specific snRNP Proteins

Shi, Y., Reddy, B. D., & Manley, J. L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.022 · Cited by 131

Competition between the ATPase Prp5 and Branch Region-U2 snRNA Pairing Modulates the Fidelity of Spliceosome Assembly

Xu, Y., & Query, C. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.022 · Cited by 129

ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8

Maeder, C., Kutach, A. K., & Guthrie, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1535 · Cited by 128

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicingPreprint

Perriman, R., & Ares, M. (2007) · Genes & Development · doi:10.1101/gad.1524307 · Cited by 124

RNA splicing: What has phosphorylation got to do with it?

Misteli, T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80128-6 · Cited by 122

The Prp19-associated Complex Is Required for Specifying Interactions of U5 and U6 with Pre-mRNA during Spliceosome Activation

Chan, S., & Cheng, S.-C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505060200 · Cited by 122

Repositioning of the Reaction Intermediate within the Catalytic Center of the Spliceosome

Konarska, M. M., Vilardell, J., & Query, C. C. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.017 · Cited by 120

Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation

Schneider, M., Hsiao, H., Will, C. L., Giet, R., Urlaub, H., & Lührmann, R. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1718 · Cited by 115

Interaction between a G-Patch Protein and a Spliceosomal DEXD/H-Box ATPase That Is Critical for Splicing

Silverman, E. J., Maeda, A., Wei, J., Smith, P., Beggs, J. D., & Lin, R.-J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10101-10110.2004 · Cited by 115

Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible

Tseng, C. K., & Cheng, S.-C. (2008) · Science · doi:10.1126/science.1158993 · Cited by 112

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingPreprint

Hilliker, A. K., Mefford, M. A., & Staley, J. P. (2007) · Genes & Development · doi:10.1101/gad.1536107 · Cited by 109

Exon Definition Complexes Contain the Tri-snRNP and Can Be Directly Converted into B-like Precatalytic Splicing Complexes

Schneider, M., Will, C. L., Anokhina, M. M., Tazi, J., Urlaub, H., & Lührmann, R. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.027 · Cited by 104

Structure and function of an RNase H domain at the heart of the spliceosome

Peña, V., Rozov, A., Fabrizio, P., Lührmann, R., & Wahl, M. C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.209 · Cited by 102

Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosomePreprint

Shen, H., Zheng, X., Shen, J., Zhang, L., Zhao, R., & Green, M. R. (2008) · Genes & Development · doi:10.1101/gad.1657308 · Cited by 100

An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition

House, A. E., & Lynch, K. W. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1149 · Cited by 98

CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS

Stark, H., & Lührmann, R. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.101953 · Cited by 97

Visualizing the splicing of single pre-mRNA molecules in whole cell extract

Crawford, D. J., Hoskins, A. A., Friedman, L. J., Gelles, J., & Moore, M. J. (2007) · RNA · doi:10.1261/rna.794808 · Cited by 97

Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation

Kuhn, A. N., van Santen, M. A., Schwienhorst, A., Urlaub, H., & Lührmann, R. (2008) · RNA · doi:10.1261/rna.1332609 · Cited by 97

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2

Zhang, L., Xu, T., Maeder, C., Bud, L.-O., Shanks, J., Nix, J. C., Guthrie, C., Pleiss, J. A., & Zhao, R. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1625 · Cited by 93

Biochemical and NMR analyses of an SF3b155–p14–U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing

Spadaccini, R., Reidt, U., Dybkov, O., Will, C. L., Frank, R., Stier, G., Corsini, L., Wahl, M. C., Lührmann, R., & Sattler, M. (2006) · RNA · doi:10.1261/rna.2271406 · Cited by 92

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing

Liu, L., Query, C. C., & Konarska, M. M. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1240 · Cited by 91

Spliceosome Assembly and Composition

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The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome

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