Molecular Parallels between Neural and Vascular Development
Open accessAbstract
The human central nervous system (CNS) features a network of ~400 miles of blood vessels that receives >20% of the body's cardiac output and uses most of its blood glucose. Many human diseases, including stroke, retinopathy, and cancer, are associated with the biology of CNS blood vessels. These vessels originate from extrinsic cell populations, including endothelial cells and pericytes that colonize the CNS and interact with glia and neurons to establish the blood-brain barrier and control cerebrovascular exchanges. Neurovascular interactions also play important roles in adult neurogenic niches, which harbor a unique population of neural stem cells that are intimately associated with blood vessels. We here review the cellular and molecular mechanisms required to establish the CNS vascular network, with a special focus on neurovascular interactions and the functions of vascular endothelial growth factors.
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Evidence obtained from developmental studies clearly depicts an orchestrated interaction between the neural and vascular systems for proper establishment of the BBB and wiring of the brain.
“To date, evidence obtained from developmental studies clearly depicts an orchestrated interaction between the neural and vascular systems for proper establishment of the BBB and wiring of the brain (22, 93, 158).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [158]
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Blood-Brain Barrier: From Physiology to Disease and Back
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- Authors
- Eichmann, A., & Thomas, J.-L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-09-28
- Volume
- 3
- Issue
- 1
- Pages
- a006551-a006551
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC3530036
- OpenAlex
- W2149644560
- Cited by
- 133
- References
- 11
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 5 · 2016: 13 · 2015: 12 · 2014: 7 · 2013: 5 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neurovascular interactions, blood-brain barrier, vascular endothelial growth factor, endothelial cells, pericytes, neural stem cells, neurogenic niche, stroke, retinopathy
- MeSH terms
- Blood-Brain Barrier, Brain, Cardiovascular System, Central Nervous System, Endothelium, Vascular, Humans, Neoplasms, Retinal Diseases, Signal Transduction, Pericytes, Stroke, Vascular Endothelial Growth Factor A, Endothelial Cells
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