A specialized vascular niche for adult neural stem cells

Tavazoie, Masoud; Van der Veken, Lieven; Silva-Vargas, Violeta; Louissaint, Marjorie; Colonna, Lucrezia; Zaidi, Bushra; Garcia-Verdugo, Jose Manuel; Doetsch, Fiona

doi:10.1016/j.stem.2008.07.025

Cited by 1,033Neurogenesis and neuroplasticity mechanismsBarrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

A specialized vascular niche for adult neural stem cells

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Tavazoie, Masoud, Van der Veken, Lieven, Silva-Vargas, Violeta, Louissaint, Marjorie, Colonna, Lucrezia, Zaidi, Bushra, Garcia-Verdugo, Jose Manuel, Doetsch, Fiona·2008·Cell stem cell

DOI 10.1016/j.stem.2008.07.025PMC PMC6864413

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Abstract

Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult subventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.

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Adult V-SVZ NSCs contact the cerebrospinal fluid at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature.
“They contact the cerebrospinal fluid in the ventricles at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature (Mirzadeh et al., 2008; Shen et al., 2008; Tavazoie et al., 2008).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Tavazoie et al., 2008

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Authors: Tavazoie, M., Van der Veken, L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, B., Garcia-Verdugo, J. M., & Doetsch, F.
Affiliations: Columbia University (US)
Corresponding author: Doetsch, Fiona
ORCID: Tavazoie, Masoud
Silva-Vargas, Violeta
Colonna, Lucrezia
Zaidi, Bushra
Doetsch, Fiona
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2008-09
Volume: 3
Issue: 3
Pages: 279-288
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2008.07.025
PMC: PMC6864413
OpenAlex: W2108340830
Cited by: 1,033
References: 55
Citations by year: 2026: 13 · 2025: 21 · 2024: 31 · 2023: 22 · 2022: 35 · 2021: 48 · 2020: 59 · 2019: 61 · 2018: 49 · 2017: 60 · 2016: 59 · 2015: 71 · 2014: 88 · 2013: 79 · 2012: 95
FWCI: 24.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (T32GM008224, T32GM007367)
National Institute of Neurological Disorders and Stroke (R01NS053884)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: neural stem cells, stem cell niche, subventricular zone, vascular system, blood-brain barrier, pericytes, astrocyte endfeet, transit amplifying cells, self-renewal, tissue regeneration
MeSH terms: Animals, Blood Vessels, Brain, Cell Differentiation, Cell Division, Humans, Mice, Inbred Strains, Lateral Ventricles, Mice, Adult Stem Cells

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A specialized vascular niche for adult neural stem cells

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