Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions
Open accessAbstract
There is an emerging understanding of the importance of the vascular system within stem cell niches. Here, we examine whether neural stem cells (NSCs) in the adult subventricular zone (SVZ) lie close to blood vessels, using three-dimensional whole mounts, confocal microscopy, and automated computer-based image quantification. We found that the SVZ contains a rich plexus of blood vessels that snake along and within neuroblast chains. Cells expressing stem cell markers, including GFAP, and proliferation markers are closely apposed to the laminin-containing extracellular matrix (ECM) surrounding vascular endothelial cells. Apical GFAP+ cells are admixed within the ependymal layer and some span between the ventricle and blood vessels, occupying a specialized microenvironment. Adult SVZ progenitor cells express the laminin receptor alpha6beta1 integrin, and blocking this inhibits their adhesion to endothelial cells, altering their position and proliferation in vivo, indicating that it plays a functional role in binding SVZ stem cells within the vascular niche.
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Adult V-SVZ NSCs contact the cerebrospinal fluid at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature.
“They contact the cerebrospinal fluid in the ventricles at the center of pinwheels formed by ependymal cells and extend a long process to the vasculature (Mirzadeh et al., 2008; Shen et al., 2008; Tavazoie et al., 2008).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Shen et al., 2008
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- Authors
- Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.-M., Goderie, S. K., Roysam, B., & Temple, S.
- Affiliations
- Neural Stem Cell Institute (US)
- Rensselaer Polytechnic Institute (US)
- Kaohsiung Medical University (TW)
- Corresponding author
- Temple, Sally
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 289-300
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC2747473
- OpenAlex
- W2070306500
- Cited by
- 1,027
- References
- 46
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 37 · 2021: 41 · 2020: 49 · 2019: 58 · 2018: 54 · 2017: 53 · 2016: 57 · 2015: 79 · 2014: 89 · 2013: 87 · 2012: 100
- FWCI
- 24.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Engineering Research Centers
- National Institutes of Health
- National Institute on Drug Abuse (T32DA007307)
- National Institute of Neurological Disorders and Stroke (R01NS051531)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- subventricular zone, neural stem cells, vascular niche, blood vessels, cell-cell interactions, laminin, alpha6beta1 integrin, endothelial cells, extracellular matrix, ependymal layer, stem cell adhesion, cell proliferation, glial fibrillary acidic protein
- MeSH terms
- Animals, Blood Vessels, Cell Communication, Glial Fibrillary Acidic Protein, Mice, Transgenic, Lateral Ventricles, Integrin alpha6beta1, Green Fluorescent Proteins, Mice, Adult Stem Cells
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